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Sci Rep ; 14(1): 1448, 2024 01 16.
Artículo en Inglés | MEDLINE | ID: mdl-38228854

RESUMEN

Breast cancer is a significant global health burden, causing a substantial number of deaths. Systemic metastatic tumour cell dissemination is a major cause of poor outcomes. Understanding the mechanisms underlying metastasis is crucial for effective interventions. Changes in the extracellular matrix play a pivotal role in breast cancer metastasis. In this work, we present an advanced multimodal X-ray computed tomography, by combining Small-angle X-ray Scattering Tensor Tomography (SAXS-TT) and X-ray Fluorescence Computed Tomography (XRF-CT). This approach likely brings out valuable information about the breast cancer metastasis cascade. Initial results from its application on a breast cancer specimen reveal the collective influence of key molecules in the metastatic mechanism, identifying a strong correlation between zinc accumulation (associated with matrix metalloproteinases MMPs) and highly oriented collagen. MMPs trigger collagen alignment, facilitating breast cancer cell intravasation, while iron accumulation, linked to angiogenesis and vascular endothelial growth factor VEGF, supports cell proliferation and metastasis. Therefore, these findings highlight the potential of the advanced multimodal X-ray computed tomography approach and pave the way for in-depth investigation of breast cancer metastasis, which may guide the development of novel therapeutic approaches and enable personalised treatment strategies, ultimately improving patient outcomes in breast cancer management.


Asunto(s)
Neoplasias de la Mama , Melanoma , Neoplasias Cutáneas , Humanos , Femenino , Neoplasias de la Mama/patología , Factor A de Crecimiento Endotelial Vascular , Rayos X , Dispersión del Ángulo Pequeño , Difracción de Rayos X , Metaloproteinasas de la Matriz/metabolismo , Colágeno , Metástasis de la Neoplasia
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