RESUMEN
People with head and neck cancer (HNC) experience elevated symptom toxicity and co-morbidity as a result of treatment, which is associated with poorer psychosocial and quality-of-life (QoL) outcomes. This Phase I study examined whether an individualised mindfulness-based stress reduction (IMBSR) programme could be successfully used with HNC patients undergoing curative treatment. Primary aims were to explore feasibility, compliance, acceptability and fidelity. Secondary aims were to determine whether (1) participation in the intervention was associated with changes in post-intervention mindfulness and (2) post-intervention mindfulness was associated with post-intervention distress and QoL. Nineteen HNC patients participated in a seven-session IMBSR programme with pre- and post-test outcome measures of psychological distress, depression, anxiety and QoL. Primary aims were assessed by therapists or participants. Mindfulness, distress and QoL were assessed using self-report questionnaires at pre- and post-intervention. Longer time spent meditating daily was associated with higher post-intervention mindfulness. After controlling for pre-intervention mindfulness, there was an association between higher post-intervention mindfulness and lower psychological distress and higher total, social and emotional QoL. This study offers important preliminary evidence than an IMBSR intervention can be administered to HNC patients during active cancer treatment. A randomised controlled trial is warranted to confirm these findings.
Asunto(s)
Ansiedad/terapia , Carcinoma de Células Escamosas/radioterapia , Depresión/terapia , Neoplasias de Cabeza y Cuello/radioterapia , Atención Plena/métodos , Estrés Psicológico/terapia , Adulto , Anciano , Ansiedad/psicología , Australia , Carcinoma de Células Escamosas/psicología , Depresión/psicología , Femenino , Neoplasias de Cabeza y Cuello/psicología , Humanos , Modelos Lineales , Masculino , Persona de Mediana Edad , Proyectos Piloto , Calidad de Vida/psicología , Carcinoma de Células Escamosas de Cabeza y Cuello , Estrés Psicológico/psicología , Encuestas y Cuestionarios , Adulto JovenRESUMEN
The effects of bethanechol in the treatment of dry mouth were assessed in patients with xerostomia after radiation therapy to the head and neck. Bethanechol possesses muscarinic and nicotinic-cholinergic activity that likely accounts for its mode of action. Bethanechol (25 mg, three times daily) was not associated with significant side effects. Statistically significant increases in whole resting saliva (p = 0.003) and whole stimulated saliva (p = 0.001) were seen. In patients with pretreatment stimulated saliva volumes greater than resting saliva volumes, a positive response to subsequent use of the sialagogue was seen.