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1.
Int J Womens Dermatol ; 9(3): e101, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37860124

RESUMEN

Background: Direct-to-consumer advertisements (DTCAs) in medical marketing serve as a prominent modality to deliver information to an increasingly diverse audience of consumers and increase prescription sales. In dermatology, advertisements have the potential to shape the public's opinions, aid in the understanding of skin conditions, and raise awareness of available treatments. Objective: To investigate and characterize the representation of skin tones in DTCAs. Methods: Nielsen ratings were utilized to identify the networks most watched by Black viewers in 2022. Programming on NBCUniversal, ABC, CBS, and FOX that aired in the District of Columbia, suburban Maryland, and Northern Virginia from June 2022 to July 2022 was reviewed for DTCAs. DTCAs were then analyzed to determine the skin tones of models and skin conditions depicted on models with darkly pigmented skin. Results: Of the 106 DTCAs related to dermatologic conditions, there were 13 unique advertisements featuring 32 unique models. Four advertisements depicted the skin condition on darkly pigmented skin tones. Using the Monk Skin Tone (MST) scale to assess the 32 unique individuals, only 25% (n = 8) were rated at an MST 7 or above, and 6.25% (n = 2) were rated at an MST 10. Limitations: This study has the limitation of only sampling DTCAs from Washington, District of Columbia which does not fully represent all dermatology-related DTCAs in the United States. Conclusion: Results of this content analysis demonstrate that the number of persons of color within dermatologic DTCAs is 23%, whereas there are 13.6% Black individuals in the 2021 US census. This suggests that DTCAs are becoming more diverse since 2018. However, findings also show that the vast majority of DTCAs do not include models with darkly pigmented skin, and there remains a lack of advertisements depicting skin disease among people of color. Given the role of DTCAs in informing and aiding patients' requests for prescription drugs, representation of all skin tones is essential for this communication to be effective, especially in the field of dermatology.

5.
Aesthet Surg J ; 43(2): 205-214, 2023 02 03.
Artículo en Inglés | MEDLINE | ID: mdl-36087303

RESUMEN

BACKGROUND: DaxibotulinumtoxinA for Injection (DAXI) is a novel botulinum toxin type A formulation approved for the treatment of glabellar lines. The efficacy, safety, and extended duration of response of DAXI 40 U for glabellar lines were demonstrated in 2 Phase 3, randomized, double-blind studies (SAKURA 1 and 2) and a Phase 3 open-label trial (SAKURA 3). OBJECTIVES: The aim of this study was to evaluate the efficacy and safety of the first DAXI 40 U treatment received in SAKURA 1, 2, or 3 across age and race subgroups. METHODS: Adults with moderate-to-severe glabellar lines (Investigator Global Assessment-Frown Wrinkle Severity [IGA-FWS] and Patient FWS [PFWS] scales) were evaluated for glabellar line severity for ≤36 weeks after the first DAXI treatment. Efficacy and safety were analyzed by age (18-45, >45-55, and >55 years) and race (Asian, Black and African American, and White). RESULTS: Overall, 2785 patients were included in the efficacy analysis. The proportion of patients achieving none or mild glabellar line severity at maximum frown (IGA-FWS) after DAXI treatment was high in all age and race subgroups (>96% at Week 4). Glabellar line severity of none or mild by composite IGA-FWS and PFWS rating was maintained for a median of 24.0 weeks in all age subgroups, and for 27.0, 25.3, and 24.0 weeks in the Asian, Black and African American, and White subgroups, respectively. Treatment-emergent adverse events were similar across all subgroups. CONCLUSIONS: Consistent with the overall study population, DAXI 40 U demonstrated a high response rate and duration of effect of ≥24 weeks across all age and race subgroups.


Asunto(s)
Toxinas Botulínicas Tipo A , Fármacos Neuromusculares , Envejecimiento de la Piel , Adulto , Humanos , Persona de Mediana Edad , Frente , Inyecciones , Método Doble Ciego , Inmunoglobulina A , Resultado del Tratamiento
6.
Cutis ; 109(1): 40-42, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35180055

RESUMEN

Alopecia has been one of the more common concerns reported at teledermatology (TD) visits during the COVID-19 pandemic. In light of the growing use of TD, a team of experts were consulted to develop workflows for virtual hair and scalp examinations, with particular consideration for skin of color patients.


Asunto(s)
COVID-19 , Telemedicina , Alopecia/diagnóstico , Humanos , Pandemias , SARS-CoV-2 , Pigmentación de la Piel
7.
J Am Acad Dermatol ; 86(4): 729-739, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35189253

RESUMEN

Recent years have brought forth the undeniable practice gap in dermatology concerning knowledge and experience of cosmetic procedures in people of color (POC). A paucity in the literature regarding evidence-based recommendations for the management of POC undergoing cosmetic procedures and the rise of cosmetic procedures in dermatology serves as a call to action to provide education regarding differences in skin of color that may impact the cosmetic outcomes. To mitigate the current practice gap on the safety, use, and benefits of cosmetic procedures in POC, part 2 will discuss the authors' recommendations and clinical pearls, as well as evidence-based management for neuromodulators, soft tissue augmentation, chemexfoliating agents, and laser hair reduction in POC undergoing cosmetic procedures.


Asunto(s)
Técnicas Cosméticas , Pigmentación de la Piel , Cabello , Humanos , Rayos Láser , Neurotransmisores/uso terapéutico
8.
J Am Acad Dermatol ; 86(4): 715-725, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35189254

RESUMEN

Increased life expectancy, focus on appearance, and readily available and accessible cosmetic procedures have served to drive an increase in the number of nonsurgical cosmetic procedures performed in the last 20 years. Demographic shifts in the United States, with increases in diverse populations that seek nonsurgical cosmetic procedures, have resulted in the need for a better understanding of cultural preferences as well as structural and biological differences in the skin of people of color (POC). Although many advances in the form of cosmeceuticals, cosmetics, and photoprotection have been made to address the aesthetic needs of and minimize complications in POC, nonsurgical cosmetic procedures are required to address common aesthetic concerns. Gaps remain in the education of dermatologists regarding the appropriate selection and execution of nonsurgical cosmetic procedures in POC. This educational initiative will facilitate a favorable outcome and optimal cosmetic results for POC.


Asunto(s)
Técnicas Cosméticas , Cosméticos , Envejecimiento de la Piel , Estética , Etnicidad , Humanos , Pigmentación de la Piel , Estados Unidos
9.
J Clin Aesthet Dermatol ; 14(8): 34-40, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34840655

RESUMEN

BACKGROUND: As aesthetic preferences have evolved and patients wish their muscles to be relaxed, but not frozen, a higher dilution of incobotulinumtoxinA (INCO) has allowed for increased spread using fewer units, yet no studies to date have investigated the efficacy, longevity, and safety of hyperdiluted INCO. OBJECTIVE: We evaluated the effect of incobotulinumtoxinA (INCO) in glabellar, forehead, and lateral periorbital lines using a high dilution. METHODS: Subjects with moderate-to-severe upper facial lines at rest according to the Merz Aesthetics Scales™ (Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany) received 15U of INCO to the glabellar (n=4 injection sites), 10U to the rest of the forehead (n=10 injection sites), and 5U to the lateral periorbital lines (n=3 injection sites/eye). Primary outcomes were physician- and subject-rated improvement at one month using the Global Aesthetic Improvement Scale (GAIS) and changes in line severity using the Merz Aesthetics Scales™. RESULTS: The study included 15 women aged 35 to 65 years. At one month, physician GAIS scores indicated 91.2% of subjects were very much improved and 8.8% were much improved; 91.5%, 78.0%, and 57.6% of participants remained at least improved at four, five, and six months, respectively. Subject GAIS scores at one month were in agreement with physician scores. At one month, an improvement of at least one point in Merz Aesthetics Scales™ scores in glabellar, forehead, and lateral periorbital lines was reported in 88.9%, 98.3%, and 94.8% of participants, respectively. Subject satisfaction was high throughout the study. No treatment-related adverse events were observed. CONCLUSION: Hyperdilute INCO was effective at improving overall appearance and reducing line severity in individuals with moderate-to-severe upper facial lines. Patient satisfaction was maintained up to six months and treatment was well tolerated.

10.
J Drugs Dermatol ; 18(7): 615, 2019 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-31329381

RESUMEN

Many cultures associate beauty with an even complexion. It has been shown in many reported references, the major cosmetic concern in patients of color is discoloration. This issue addresses discoloration of individuals of color and the use of a multitude of preparations that can blend the complexion. Authors in Asia, Sweden, France, and Brazil discuss the use of injectable deoxycholic acid in nonsubmental regions and hyaluronic acid for skin boosting, an off-label usage or procedures in the United States. Skin boosting improves hydration and the smoothness of the skin. Additionally, international methods of treating cosmetic patients with multiple modalities are discussed.


Asunto(s)
Queratosis Seborreica/terapia , Rosácea/terapia , Neoplasias Cutáneas/terapia , Pigmentación de la Piel , Pueblo Asiatico , Población Negra , Técnicas Cosméticas , Femenino , Hispánicos o Latinos , Humanos , Queratosis Seborreica/diagnóstico , Factores de Riesgo , Rosácea/diagnóstico , Piel/efectos de la radiación , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/etiología , Luz Solar/efectos adversos
11.
J Drugs Dermatol ; 17(9): 960-965, 2018 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-30235382

RESUMEN

INTRODUCTION: This was a prospective non-randomized observational study of female subjects seeking treatment for cellulite who were consecutively enrolled into a registry. The objective was to evaluate the efficacy and safety of a tissue stabilized-guided subcision device for the treatment of cellulite using three-dimensional (3D) imaging analysis. METHODS: Subjects received a single treatment to the buttocks and/or posterolateral thighs with the study device. Follow-up telephone evaluations were conducted at 3 and 14 days to evaluate safety and 30 and 90 days to evaluate efficacy. Subjects returned to clinic at three months to obtain follow-up two dimensional and 3D imaging. RESULTS: Sixteen women of average age 44.1 years with a total of 291 lesions of cellulite were treated. Thirteen subjects presented for all follow up visits. Physicians graded results an average of 2.23/5 or "much improved" to "improved" with 9 subjects as much or very much improved (69.2%). Blinded assessors graded overall improvement an average of 2.8 (26-75% improvement) with 8 subjects having greater than 50% improvement overall (61.6%). Improvement in dimple depth was graded an average of 2.9, with 9 subjects having greater than 50% improvement (69.2%). Analysis of 3D imaging yielded 67.4% average improvement in negative volume and 58.4% improvement in minimum height of dimples. Most expected treatment effects resolved within three months after treatment. CONCLUSION: Utilizing three-dimensional imaging analysis, investigators quantitatively and objectively demonstrated efficacy of a tissue stabilized-guided subcision device in the treatment of cellulite of the buttocks and thighs. J Drugs Dermatol. 2018;17(9):960-965.


Asunto(s)
Celulitis/cirugía , Satisfacción del Paciente , Adulto , Nalgas , Celulitis/diagnóstico por imagen , Femenino , Humanos , Imagenología Tridimensional , Entrevistas como Asunto , Láseres de Estado Sólido , Procedimientos Quirúrgicos Mínimamente Invasivos , Estudios Prospectivos , Muslo , Resultado del Tratamiento , Vacio
12.
J Drugs Dermatol ; 17(9): 966-969, 2018 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-30235383

RESUMEN

BACKGROUND: Melatonin is an endogenous hormone commonly associated with regulation of sleep. However, over the last two decades, research has elucidated a range of effects associated with the compound, including anti-inflammatory, both direct and indirect antioxidant activity, tissue regenerative benefits, and preservation of mitochondrial function. Melatonin's anti-inflammatory and antioxidant support, coupled with its mitochondrial support, make it an intriguing target for use to support skin health. Human skin and hair follicles express functional melatonin receptors. They also engage in substantial melatonin synthesis. By supporting cutaneous homeostasis, melatonin and its metabolites are thought to attenuate carcinogenesis and possibly other pathological processes, including hyperproliferative/inflammatory conditions. The primary extrinsic driver of aging has been considered to be exposure to ultraviolet (UV) light, which is well-established to contribute to sunburn, immunosuppression, skin aging, and carcinogenesis. Topically applied melatonin has been shown to reduce markers of reactive oxygen species formation and to reverse signs of skin aging. As the global population continues to age, photo-damage remains a significant cutaneous concern. While use of sunscreens and UV avoidance strategies are essential to mitigate skin cancer risks, the potential to protect the skin and improve the appearance of photo-damage through the use of topical antioxidant support is appealing. The evidence suggests that melatonin deserves consideration for topical use as an anti-aging and skin protective agent. It is shown to be both safe and effective when topically applied. J Drugs Dermatol. 2018;17(8):966-969.


Asunto(s)
Antioxidantes/uso terapéutico , Melatonina/uso terapéutico , Envejecimiento de la Piel , Administración Cutánea , Antioxidantes/administración & dosificación , Humanos , Melatonina/administración & dosificación , Protectores Solares/administración & dosificación , Protectores Solares/uso terapéutico
13.
Dermatol Surg ; 43 Suppl 2: S140-S150, 2017 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29064976

RESUMEN

BACKGROUND: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population. OBJECTIVE: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. METHODS: A MEDLINE search was performed for publications on sex and racial differences in basic science of skin, common disorders in men of color, and evidence-based treatments. RESULTS: There are intrinsic differences in skin and hair of darker-complexioned men, particularly in Hispanics, African Americans, Asians, and Afro-Caribbeans. Advantages of darker skin include increased photoprotection, slowed aging, and a lower incidence of skin cancer. However, the increased content of melanin is associated with myriad dyschromias including melasma and postinflammatory hyperpigmentation (PIH). Additional common skin conditions of concern in men of color include pseudofolliculitis barbae, acne keloidalis nuchae, and keloids. CONCLUSION: A skin color conscious approach should be administered in caring for the cosmetic concerns of men of color that is cognizant of differences in biology of the skin and hair, associated PIH of disorders, and cultural/social practices among this population.


Asunto(s)
Técnicas Cosméticas , Enfermedades del Cabello/terapia , Cabello , Grupos Raciales , Enfermedades de la Piel/terapia , Pigmentación de la Piel , Humanos , Masculino
14.
Cutis ; 100(6): 375-380, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29360898

RESUMEN

Facial concerns in skin of color (SOC) patients vary and can be a source of emotional and psychological distress. This article discusses 4 common facial concerns in SOC patients: acne, rosacea, facial hyperpigmentation, and cosmetic enhancement. Treatment recommendations are provided as well as management pearls.


Asunto(s)
Acné Vulgar/terapia , Técnicas Cosméticas , Hiperpigmentación/terapia , Rosácea/terapia , Acné Vulgar/psicología , Humanos , Hiperpigmentación/psicología , Rosácea/psicología , Pigmentación de la Piel
15.
Dermatol Surg ; 41(11): 1310-9, 2015 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-26509943

RESUMEN

BACKGROUND: IncobotulinumtoxinA and onabotulinumtoxinA are indicated for the temporary improvement in the appearance of glabellar frown lines (GFL). This is the first randomized direct comparator study to date, at the Food and Drug Administration-recommended dose of 20 units (U), for the treatment of GFL. OBJECTIVE: To investigate the dose equivalence of incobotulinumtoxinA (20 U) and onabotulinumtoxinA (20 U) for the treatment of moderate-to-severe GFL. MATERIALS AND METHODS: Prospective, randomized (1:1), double-blinded, parallel-group study in 250 females (18-50 years), employing a single treatment with incobotulinumtoxinA or onabotulinumtoxinA, followed by a 4-month observational period. RESULTS: At the primary efficacy endpoint (1 month after treatment), incobotulinumtoxinA was equivalent to onabotulinumtoxinA in the treatment of GFL at the 20 U dose within the prespecified ± 15% margin of equivalence. Efficacy remained similar between treatment groups through 4 months after treatment as assessed by the independent masked panel and the masked treating physicians. Patient satisfaction ratings were similar between groups and favorable (>90%) throughout. Both treatments were well tolerated. CONCLUSION: Equivalence was demonstrated at the primary endpoint between incobotulinumtoxinA and onabotulinumtoxinA in the treatment of GFL at the 20 U dose at 1 month. Similar efficacy and tolerability profiles were observed through 4 months after treatment.


Asunto(s)
Toxinas Botulínicas Tipo A/administración & dosificación , Músculos Faciales/efectos de los fármacos , Fármacos Neuromusculares/administración & dosificación , Envejecimiento de la Piel/efectos de los fármacos , Adulto , Toxinas Botulínicas Tipo A/farmacocinética , Método Doble Ciego , Femenino , Frente , Humanos , Persona de Mediana Edad , Fármacos Neuromusculares/farmacocinética , Satisfacción del Paciente , Estudios Prospectivos , Equivalencia Terapéutica , Factores de Tiempo , Resultado del Tratamiento , Adulto Joven
16.
J Drugs Dermatol ; 9(5): 451-6, 2010 May.
Artículo en Inglés | MEDLINE | ID: mdl-20480787

RESUMEN

With demand for minimally invasive cosmetic procedures rising in patients of color, it is becoming increasingly important for clinical dermatologists to be aware of specific needs of these patients. This article therefore reviews considerations for using cosmetic procedures on skin of color, and reports the authors' clinical experience with the use of injectable poly-L-lactic acid (PLLA, Sculptra, Dermik Laboratories, a business of sanofi-aventis U.S. LLC) in this patient population. The authors' experience indicates that patients with skin of color may require an increased interval between treatments; however, with proper attention to patient selection and administration technique, injectable PLLA can be used effectively in this patient group. Controlled clinical studies that include more patients of color are needed to fully assess the benefits and risks of cosmetic products, such as injectable PLLA, in these populations.


Asunto(s)
Materiales Biocompatibles/efectos adversos , Ácido Láctico/uso terapéutico , Polímeros/uso terapéutico , Grupos Raciales , Materiales Biocompatibles/administración & dosificación , Materiales Biocompatibles/uso terapéutico , Técnicas Cosméticas/efectos adversos , Humanos , Ácido Láctico/administración & dosificación , Ácido Láctico/efectos adversos , Selección de Paciente , Poliésteres , Polímeros/administración & dosificación , Polímeros/efectos adversos , Envejecimiento de la Piel/efectos de los fármacos , Envejecimiento de la Piel/etnología , Factores de Tiempo
17.
Dermatol Surg ; 35 Suppl 2: 1653-60, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19807760

RESUMEN

BACKGROUND: Nonanimal stabilized hyaluronic acid (NASHA) dermal fillers have been used in the United States since 2003 for the treatment of moderate to severe facial wrinkles and folds, such as nasolabial folds. Previous trials with NASHA dermal fillers have included small numbers of patients with pigmented skin. OBJECTIVES: This randomized, evaluator-blinded, split-face trial compared the safety and efficacy of two variable-particle NASHA fillers in the correction of nasolabial folds in patients with Fitzpatrick skin types IV, V, and VI. METHODS AND MATERIALS: One hundred fifty patients (predominantly African American) were enrolled at 10 sites. Patients received one treatment (with an optional touch-up treatment at week 2) with small- and large-particle NASHA gel randomized to the left or right side of the face. Safety was evaluated through patient diaries for the first 2 weeks and physician assessments at 3 days and 2, 6, 12, and 24 weeks after treatment for adverse events (AEs), skin pigmentation changes, and keloid formation. RESULTS: All related AEs were mild or moderate and of limited duration. They included bruising, tenderness, edema, redness, itching, pain, and changes in pigmentation. The incidence of AEs was not different between the 2 preparations, and no patient developed a keloid. There were 3 reported mass formations, 2 of which were infectious in nature. CONCLUSION: In patients with skin of color, NASHA dermal fillers are safe for the correction of moderate to severe facial folds and wrinkles, with no immunogenicity or keloid formation and only mild to moderate AEs occurring around the injection site.


Asunto(s)
Materiales Biocompatibles/efectos adversos , Fármacos Dermatológicos/efectos adversos , Ácido Hialurónico/efectos adversos , Hiperpigmentación/inducido químicamente , Inyecciones Intradérmicas/métodos , Envejecimiento de la Piel/efectos de los fármacos , Adolescente , Adulto , Anciano , Materiales Biocompatibles/administración & dosificación , Fármacos Dermatológicos/administración & dosificación , Eritema/inducido químicamente , Cara , Femenino , Humanos , Ácido Hialurónico/administración & dosificación , Masculino , Persona de Mediana Edad , Philadelphia , Estudios Prospectivos , Método Simple Ciego , Resultado del Tratamiento
19.
J Drugs Dermatol ; 6(1): 51-5, 2007 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17373161

RESUMEN

In recent years, people of color have become an increasingly important market force for the cosmetics industry. Product lines have been expanded to accommodate a broader spectrum of skin colors and marketing strategies have been specialized in order to target specific ethnic populations. In addition, it is predicted that people with pigmented skin will eventually comprise a majority of the domestic and international population during the 21st century. Not surprisingly, people of color are increasingly seeking out products and procedures to fight the effects of aging, including an increase in surgical and nonsurgical cosmetic procedures. Among nonsurgical procedures, soft tissue augmentation has experienced dramatic growth. Today, clinicians are performing more and more of these procedures in people of color. As a result of these shifts in the cosmetics industry, clinicians performing soft tissue augmentation require increased expertise in the treatment of ethnic skin. This article reviews the important differences that exist between the appearance of the aging faces of Caucasians and people of color. In addition, soft tissue augmentation strategies and injection techniques that are specific to skin of color are discussed.


Asunto(s)
Pigmentación de la Piel/fisiología , Piel/fisiopatología , Expansión de Tejido/métodos , Materiales Biocompatibles/administración & dosificación , Materiales Biocompatibles/química , Técnicas Cosméticas/normas , Técnicas Cosméticas/tendencias , Procedimientos Quirúrgicos Dermatologicos , Humanos , Piel/efectos de los fármacos , Envejecimiento de la Piel/fisiología , Pigmentación de la Piel/efectos de los fármacos
20.
Cutis ; 78(2 Suppl 2): 6-19, 2006 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-16977792

RESUMEN

Postinflammatory hyperpigmentation (PIH) is a common acquired excess of pigment in the epidermal and/or dermal layers of the skin. Lesions persist for extended periods if untreated, thus therapy is warranted. Topical monotherapies include the standard bleaching agent hydroquinone (HQ) as well as retinoids. Recently, several fixed-dose combination products were introduced to the armamentarium: HQ 4%-retinol 0.15% in a microsponge formulation; HQ 4%-retinol 0.3%; mequinol 2%-tretinoin (RA) 0.01%; and fluocinolone acetonide (FA) 0.01%, HQ 4%, and RA 0.05%. Recent findings have suggested that mequinol 2%-RA 0.01% solution is a promising alternative for the treatment of PIH.


Asunto(s)
Dermatitis/complicaciones , Hiperpigmentación/terapia , Adolescente , Adulto , Antioxidantes/administración & dosificación , Terapia Combinada , Dermabrasión , Fármacos Dermatológicos/administración & dosificación , Femenino , Humanos , Hidroquinonas/administración & dosificación , Hiperpigmentación/diagnóstico , Hiperpigmentación/etiología , Masculino , Retinoides/administración & dosificación
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