RESUMEN
Carbapenem-resistant Enterobacteriaceae infections are becoming more common, are associated with high mortality rates, and are difficult to treat due to multiple mechanisms of resistance. We describe the successful treatment of Klebsiella pneumoniae carbapenemase-expressing Enterobacter cloacae empyema in a lung transplant recipient with cefepime and levofloxacin.
Asunto(s)
Antibacterianos/uso terapéutico , Cefalosporinas/uso terapéutico , Empiema/tratamiento farmacológico , Empiema/microbiología , Enterobacter cloacae/genética , Infecciones por Enterobacteriaceae/tratamiento farmacológico , Levofloxacino/uso terapéutico , beta-Lactamasas/genética , Cefepima , Quimioterapia Combinada , Empiema/diagnóstico , Infecciones por Enterobacteriaceae/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
Williams-Campbell syndrome is a rare disorder characterized by deficiency of subsegmental bronchial cartilage and development of airway collapse and bronchiectasis that may subsequently progress to respiratory failure and death. There are only 2 published reports suggesting a familial association, and only one report of lung transplantation being used as a therapeutic modality. Due to postoperative airway complications, transplantation has not been recommended for this disease. We report the first lung transplant with prolonged survival, approaching 10 years, in a patient with Williams-Campbell syndrome, and provide further evidence to support a familial association.