RESUMEN
Recientemente la ingestión accidental de cremas tópicas antipsoriáticas se ha descrito en perros. En el presente trabajo se revisan los casos más documentados que se han registrado en el Centro Nacional de Informaciones Toxicológicas Veterinarias de Lyon (Francia) en los últimos cuatro años [1999-2003], de intoxicación en perros por tacalcitol y calcipotriol. De los 20 casos seleccionados 9 son por calcipotriol y 11 por tacalcitol. Se han observado efectos a nivel gastrointestinal, neuromotor, hepático y renal. Se observan a su vez alteraciones en distintos parámetros bioquímicos. Apreciamos un menor tiempo medio de aparición de síntomas en los intoxicados por tacalcitol, así como un mayor porcentaje de mortalidad. De la discusión de los datos disponibles podemos concluir que la intoxicación por tacalcitol es mucho más severa en perros que la intoxicación por calcipotriol (AU)
Recently, accidental ingestion of topical antipsoriatic ointments in dogs has been described. This work describes the most documented cases of accidental poisoning, by tacalcitol and calcipotriol, in dogs registered by the National Centre of Veterinary Toxicological Information in Lyon (France) during the last four years [1999-2003]. 20 accidental poisoning cases have been selected due to the involvement of the aforementioned substances, 9 cases by calcipotriol and the other 11 cases by tacalcitol. These substances caused effects on gastrointestinal and neuromotor systems, liver and kidneys. In addition, some modifications were observed with biochemical parameters. Mortality percentages were higher in the cases by tacalcitol, and the clinical signs after ingestion appeared earlier than in the cases involving calcipotriol. According to the results we can concluded that tacalcitol accidental poisonings in dogs are more severe than those by calcipotriol (AU)
Asunto(s)
Animales , Masculino , Femenino , Perros , Intoxicación/complicaciones , Intoxicación/veterinaria , Hipercalcemia/inducido químicamente , Hipercalcemia/complicaciones , Hipercalcemia/diagnóstico , Calcitriol/toxicidad , /complicaciones , /diagnóstico , /veterinaria , Farmacovigilancia , Monitoreo de Drogas , Monitoreo de Drogas/veterinaria , Administración TópicaRESUMEN
This paper presents the result of a 4 year survey in France (1991-1994) based on the activity of a wildlife disease surveillance network (SAGIR). The purpose of this study was to evaluate the detrimental effects of anticoagulant (Ac) rodenticides in non-target wild animals. Ac poisoning accounted for a very limited number of the identified causes of death (1-3%) in most species. Predators (mainly foxes and buzzards) were potentially exposed to anticoagulant compounds (especially bromadiolone) via contaminated prey in some instances. The liver concentrations of bromadiolone residues were elevated and species-specific diagnostic values were determined. These values were quite similar to those reported in the literature when secondary anticoagulant poisoning was experimentally assessed.
Asunto(s)
4-Hidroxicumarinas/envenenamiento , Anticoagulantes/envenenamiento , Aves , Zorros , Hígado/metabolismo , Rodenticidas/envenenamiento , 4-Hidroxicumarinas/metabolismo , Animales , Anticoagulantes/metabolismo , Monitoreo del Ambiente , Francia , Indanos/metabolismo , Indanos/envenenamiento , Estaciones del Año , Especificidad de la EspecieRESUMEN
A retrospective study was conducted of 40 loperamide poisoning cases recorded at the Centre National d'Informations Toxicologiques Veterinaires. An apparent breed susceptibility of Collie dogs was observed. Neurologic disturbances (ataxia and prostration) were significant clinical findings. Treatment with naloxone resulted in rapid reversal of signs without sequelae.
Asunto(s)
Antidiarreicos/envenenamiento , Enfermedades de los Perros/inducido químicamente , Loperamida/envenenamiento , Animales , Enfermedades del Sistema Digestivo/inducido químicamente , Enfermedades del Sistema Digestivo/epidemiología , Enfermedades del Sistema Digestivo/veterinaria , Enfermedades de los Perros/tratamiento farmacológico , Enfermedades de los Perros/epidemiología , Perros , Femenino , Estudios de Seguimiento , Masculino , Naloxona/administración & dosificación , Naloxona/uso terapéutico , Antagonistas de Narcóticos/administración & dosificación , Antagonistas de Narcóticos/uso terapéutico , Intoxicación/tratamiento farmacológico , Intoxicación/epidemiología , Intoxicación/veterinaria , Estudios RetrospectivosRESUMEN
Information on accidental poisoning of companion animals with human drugs is seldom published. This paper presents the results of a survey conducted by the Centre National d'Informations Toxicologiques Veterinaires (CNITV) on cases recorded between January 1, 1991 and December 31, 1994 at the CNITV on the circumstances and clinical signs of accidental oral poisoning of dogs and cats by benzodiazepines. Our results showed that, among the numerous potential drugs available, bromazepam was by far most commonly encountered, especially in dogs. Clinical signs included mostly nervous disorders (hyper and hypo). Treatment was symptomatic and supportive, and the prognosis was generally good.
