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1.
Artículo en Inglés | MEDLINE | ID: mdl-6806354

RESUMEN

The authors studied combined effect of aniline (20 mg/kg for a period of 4 weeks in drinking water) and nitrosodimethylamine (NDMA) (30 mg/kg, a single intragastric dose) on the activity of enzymes of different subcellular structures: endoplasmic reticulum (cytochromes P450, B5, acetylesterase), mitochondria (malate dehydrogenase) and the content of N-acetylneuraminic acid in rat liver and of lysosomes (beta-glucuronidase, beta-galactosidase). The combined action of NDMA and aniline was accompanied by more pronounced changes in the indices under investigation than isolated administration of the given chemical substances. The most pronounced aggravation of the unfavourable changes was observed in the activity of enzymes connected with the processes of oxidation and energy supply to the cell (malate dehydrogenase) and the metabolism of glucuronides (beta-glucuronidase) as well as in the content of N-acetylneuraminic acid. This may be connected with the modifying effect of aniline on the toxic effect of NDMA.


Asunto(s)
Compuestos de Anilina/farmacología , Dimetilnitrosamina/farmacología , Lisosomas/enzimología , Microsomas Hepáticos/enzimología , Acetilesterasa/metabolismo , Animales , Sistema Enzimático del Citocromo P-450/metabolismo , Glucuronidasa/metabolismo , Hígado/enzimología , Hígado/metabolismo , Hígado/ultraestructura , Malato Deshidrogenasa/metabolismo , Masculino , Ratas , Ácidos Siálicos/metabolismo , beta-Galactosidasa/metabolismo
2.
Artículo en Inglés | MEDLINE | ID: mdl-7190985

RESUMEN

The authors performed a comparative biochemical study of some enzymes of lysosomic origin (hyaluronidase, N-acetyl-beta-D-glucosaminidase, beta-glucosidase, beta-galatosidase and acid phosphatase), of the state of enzyme substrate system N-acetylneuraminic acid---aldolase of neuramic acid and of the activity of lactatedehydrogenase (soluble in cytosol and bound on mitochodria) in the liver, lungs and blood serum of rats at various regimens of the inhalation action of CCl4. On the basis of results obtained they determined the biological importance of the change of activity of enzymes differently localized in cells at the adaptation of an organisme to the noxious action of CCl4.


Asunto(s)
Tetracloruro de Carbono/farmacología , Fructosa-Bifosfato Aldolasa/metabolismo , Hidrolasas/metabolismo , L-Lactato Deshidrogenasa/metabolismo , Hígado/enzimología , Animales , Citoplasma/enzimología , Hígado/ultraestructura , Pulmón/enzimología , Lisosomas/enzimología , Masculino , Ratas
3.
Artículo en Inglés | MEDLINE | ID: mdl-575895

RESUMEN

The authors effected a comparative examination of morphologic and biochemical investigation of structural and enzymic reactions of the rat liver during different periods of permanent inhalation influence of carbon tetrachloride. Three stages of morphologico-biochemical parllels in the development of hepatotropic effect characterized by certain regularities in the enzymic desorganization of lysosyme, mitochondrias and cytasol by derangement of the exchange of biopolymers containing carbohydrate (of glycoproteids, glycosaminoglycans) and DNK-synthetizing function in liver in comparison with control animals were revealed. Mechanisms of the hepatotropic effect and hygienic importance of structural function changes of hepatocytes due to action of factors polluting the atmosphere are appreciated.


Asunto(s)
Tetracloruro de Carbono/farmacología , Hígado/efectos de los fármacos , Contaminantes Atmosféricos/efectos adversos , Animales , Hígado/citología , Hígado/enzimología , Masculino , Ratas
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