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1.
Phys Rev Lett ; 130(7): 071002, 2023 Feb 17.
Artículo en Inglés | MEDLINE | ID: mdl-36867826

RESUMEN

We report an axion dark matter search at Dine-Fischler-Srednicki-Zhitnitskii sensitivity with the CAPP-12TB haloscope, assuming axions contribute 100% of the local dark matter density. The search excluded the axion-photon coupling g_{aγγ} down to about 6.2×10^{-16} GeV^{-1} over the axion mass range between 4.51 and 4.59 µeV at a 90% confidence level. The achieved experimental sensitivity can also exclude Kim-Shifman-Vainshtein-Zakharov axion dark matter that makes up just 13% of the local dark matter density. The CAPP-12TB haloscope will continue the search over a wide range of axion masses.

2.
Phys Rev Lett ; 130(9): 091602, 2023 Mar 03.
Artículo en Inglés | MEDLINE | ID: mdl-36930919

RESUMEN

We report the results of an axion dark matter search over an axion mass range of 9.39-9.51 µeV. A flux-driven Josephson parametric amplifier (JPA) was added to the cryogenic receiver chain. A system noise temperature of as low as 200 mK was achieved, which is the lowest recorded noise among published axion cavity experiments with phase-insensitive JPA operation. In addition, we developed a two-stage scanning method which boosted the scan speed by 26%. As a result, a range of two-photon coupling in a plausible model for the QCD axion was excluded with an order of magnitude higher in sensitivity than existing limits.

3.
Phys Rev Lett ; 126(19): 191802, 2021 May 14.
Artículo en Inglés | MEDLINE | ID: mdl-34047607

RESUMEN

The Center for Axion and Precision Physics Research at the Institute for Basic Science is searching for axion dark matter using ultralow temperature microwave resonators. We report the exclusion of the axion mass range 10.7126-10.7186 µeV with near Kim-Shifman-Vainshtein-Zakharov (KSVZ) coupling sensitivity and the range 10.16-11.37 µeV with about 9 times larger coupling at 90% confidence level. This is the first axion search result in these ranges. It is also the first with a resonator physical temperature of less than 40 mK.

4.
Acta Biomater ; 8(11): 4130-8, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22820310

RESUMEN

Sickle cell disease (SCD) is characterized by the abnormal deformation of red blood cells (RBCs) in the deoxygenated condition, as their elongated shape leads to compromised circulation. The pathophysiology of SCD is influenced by both the biomechanical properties of RBCs and their hemodynamic properties in the microvasculature. A major challenge in the study of SCD involves accurate characterization of the biomechanical properties of individual RBCs with minimum sample perturbation. Here we report the biomechanical properties of individual RBCs from a SCD patient using a non-invasive laser interferometric technique. We optically measure the dynamic membrane fluctuations of RBCs. The measurements are analyzed with a previously validated membrane model to retrieve key mechanical properties of the cells: bending modulus; shear modulus; area expansion modulus; and cytoplasmic viscosity. We find that high cytoplasmic viscosity at ambient oxygen concentration is principally responsible for the significantly decreased dynamic membrane fluctuations in RBCs with SCD, and that the mechanical properties of the membrane cortex of irreversibly sickled cells (ISCs) are different from those of the other types of RBCs in SCD.


Asunto(s)
Anemia de Células Falciformes/sangre , Anemia de Células Falciformes/patología , Eritrocitos Anormales/patología , Óptica y Fotónica/métodos , Anemia de Células Falciformes/fisiopatología , Fenómenos Biomecánicos , Forma de la Célula , Módulo de Elasticidad , Membrana Eritrocítica/metabolismo , Hemoglobinas/metabolismo , Humanos , Microscopía , Modelos Biológicos , Viscosidad
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