RESUMEN
The goal of the Xflows experimental campaign is to study the radiation flow on the National Ignition Facility (NIF) reproducing the sensitivity of the temperature (±8 eV, ±23 µm) and density (±11 mg/cc) measurements of the COAX platform [Johns et al., High Energy Density Phys. 39, 100939 (2021); Fryer et al., High Energy Density Phys. 35, 100738 (2020); and Coffing et al., Phys. Plasmas 29, 083302 (2022)]. This new platform will enable future astrophysical experiments involving supernova shock breakout, such as Radishock (Johns et al., Laboratory for Laser Energetics Annual Report 338, 2020) on OMEGA-60 [Boehly et al., Rev. Sci. Instrum. 66, 508 (1995)], and stochastic media (such as XFOL on OMEGA). Greater energy and larger physical scale on NIF [Moses et al., Eur. Phys. J. D 44, 215 (2007)] will enable a greater travel distance of radiation flow, higher density, and more manufacturable foams and enable exploration of a greater range of radiation behavior than achievable in the prior OMEGA experiments. This publication will describe the baseline configuration for the Xflows experimental campaign and the roadmap to achieve its primary objectives.
RESUMEN
We describe a technique by which magnetic field probes are used to triangulate the exact position of breakdown in a high voltage coaxial vacuum gap. An array of three probes is placed near the plane of the gap with each probe at 90° intervals around the outer (anode) electrode. These probes measure the azimuthal component of the magnetic field and are all at the same radial distance from the cylindrical axis. Using the peak magnetic field values measured by each probe, the current carried by the breakdown channel, and Ampères law we can calculate the distance away from each probe that the breakdown occurred. These calculated distances are then used to draw three circles each centered at the centers of the corresponding magnetic probes. The common intersection of these three circles then gives the predicted azimuthal location of the center of the breakdown channel. Test results first gathered on the coaxial gap breakdown device (240 A, 25 kV, 150 ns) at the University of California San Diego and then on COBRA (1 MA, 1 MV, 100 ns) at Cornell University indicate that this technique is relatively accurate and scales between these two devices.
RESUMEN
Single cell study is gaining importance because of the cell-to-cell variation that exists within cell population, even after significant initial sorting. Analysis of such variation at the gene expression level could impact single cell functional genomics, cancer, stem-cell research, and drug screening. The on-chip monitoring of individual cells in an isolated environment would prevent cross-contamination, provide high recovery yield, and enable study of biological traits at a single cell level. These advantages of on-chip biological experiments is a significant improvement for a myriad of cell analyses methods, compared to conventional methods, which require bulk samples and provide only averaged information on cell structure and function. We report on a device that integrates a mobile magnetic trap array with microfluidic technology to provide the possibility of separation of immunomagnetically labeled cells and their encapsulation with reagents into picoliter droplets for single cell analysis. The simultaneous reagent delivery and compartmentalization of the cells immediately following sorting are all performed seamlessly within the same chip. These steps offer unique advantages such as the ability to capture cell traits as originated from its native environment, reduced chance of contamination, minimal use of the reagents, and tunable encapsulation characteristics independent of the input flow. Preliminary assay on cell viability demonstrates the potential for the device to be integrated with other up- or downstream on-chip modules to become a powerful single-cell analysis tool.
