Verbal memory and executive components of recall in adolescent binge drinkers.

Introduction: Binge drinking (BD) is a common health-risk behavior among young people. Due to the incomplete maturation of the adolescent brain, BD can lead to structural and functional changes that impact neurocognitive processes, particularly executive functioning and verbal memory. This study aimed to investigate the influence of executive components, such as mnemonic strategies and error avoidance, on performance in a verbal memory test and the potential effects of BD on this performance. Methods: A sample of 160 college students (51.55% female) with a mean age of 18.12 ± 0.32 years completed assessments for alcohol use disorders using the Alcohol Use Disorder Identification Test (AUDIT), as well as psychopathological (Symptom Checklist-90-R) and neuropsychological evaluations (Verbal Learning Test Spain-Complutense and WMS-III Logical Memory). The Intensive Drinking Evaluation Instrument (IECI) was utilized to gather detailed information about binge drinking habits, including the calculation of the highest blood alcohol concentration (BAC) during an episode of intake. Results: Correlation and clustering analyses revealed a negative association between BAC values and verbal memory performance, as well as the use of memory strategies. The high BAC group (BD) exhibited negative values in verbal memory variables, higher accuracy errors, and less efficient strategy usage, while the low BAC group (No BD) demonstrated better memory test performance, fewer precision errors, and superior use of memory strategies. Discussion: These findings support the hypothesis that, when solving tests requiring verbal memory, adolescents reporting a BD consumption pattern show fewer executive skills in their resolution and, therefore, achieved poorer performance than non-binge drinkers. Addressing excessive alcohol consumption in young individuals is crucial for safeguarding their cognitive development and overall well-being.

A 2-year follow-up of the effects of combined binge drinking and cannabis consumption on academic performance and adjustment in Spanish third-year university students.

Introduction: The study was based on 2-year follow-up of the effects of binge drinking and cannabis co-consumption on academic performance and adjustment in Spanish Third-Year University Students and to further explore the impact of academic adjustment on this relationship. Methods: A total of 144 students (aged 19-20 years) enrolled in the third year of university completed the study. The students were recruited during in first academic year (T1) via a survey that included items regarding the use of alcohol (AUDIT-C), cannabis and other drugs and demographic variables. Then, participants meeting the study criteria were then selected and invited by e-mail to a clinical (face-to face) structured interview. The participants completed a calendar of alcohol consumption during the 6 months prior to the interview (Alcohol Timeline Follow back), and recorded cannabis consumption in 3 months prior to the interview. To examine the effects of alcohol and cannabis co-consumption on the outcome variables, we categorized participants into three consumption groups (i.e., control, BD, and BDCA) based on the number of BD days and cannabis unit scores. Results: Binge drinking and cannabis co-consumption in first-year students was significantly associated with poor academic performance and adjustment after 2 years of undergraduate study. Relative to controls, co-consumers (BDCA) reported significantly lower academic and personal-emotional adjustment to university as well as poorer performance. Mediation analysis showed that academic adjustment explains the mechanism by which BDCAs perform less well, mediating the relationship between co-consumption and academic performance, with an indirect effect representing 64.61% of the total effect. Furthermore, the mediating effect of academic adjustment was maintained after controlling for academic adjustment and baseline grade point average (T1). Conclusion: This prospective follow-up study helps to further our knowledge of how combined binge drinking and cannabis consumption may affect university adjustment and academic success in Spanish university students Overall, the study results should encourage health professionals, educational psychologists and academic institutions to take ownership of the need for support and involvement in prevention, as well as for provision of guidelines for implementing appropriate intervention strategies.

Neurocognitive effects of binge drinking on verbal episodic memory. An ERP study in university students.

Background: Verbal memory may be affected by engagement in alcohol binge drinking during youth, according to the findings of neuropsychological studies. However, little is known about the dynamics of the neural activity underlying this cognitive process in young, heavy drinkers. Aims: To investigate brain event-related potentials associated with cued recall from episodic memory in binge drinkers and controls. Methods: Seventy first-year university students were classified as binge drinkers (32: 17 female) or controls (38: 18 female). The participants completed a verbal paired associates learning task during electroencephalogram (EEG) recording. ERPs elicited by old and new word pairs were extracted from the cued-recall phase of the task by using Principal Component Analysis. Subjects also performed a standardized neuropsychological verbal learning test. Results: Two of the three event-related potentials components indicating old/new memory effects provided evidence for anomalies associated with binge drinking. The old/new effects were absent in the binge drinkers in the two subsequent posterior components, identified with the late parietal component and the late posterior negativity The late frontal component revealed similar old/new effects in both groups. Binge drinkers showed similar behavioural performance to controls in the verbal paired associates task, but performed poorly in the more demanding short-term cued-recall trial of a neuropsychological standardized test. Conclusion: Event-related potentials elicited during a verbal cued-recall task revealed differences in brain functioning between young binge drinkers and controls that may underlie emergent deficits in episodic memory linked to alcohol abuse. The brain activity of binge drinkers suggests alterations in the hippocampal - posterior parietal cortex circuitry subserving recognition and recollection of the cue context and generation of the solution, in relation to verbal information shallowly memorised.

Percepción del consumo de alcohol propio y de allegados en universitarios de primer curso como predictor del consumo a 10 años. / Percepción del consumo de alcohol propio y de allegados en universitarios de primer curso como predictor del consumo a 10 años.

The alcohol use perceptions young people have of those close to them can affect their expectations regarding alcohol and, thus, their own drinking. We aim to identify the predictive ability of own and significant others' perceived drinking at age 18-19 in the alcohol use patterns at 27-28. A cohort study was carried out among university students in Spain (n=1,382). Binge Drinking (BD) and Risky Consumption (RC) were measured with the Alcohol Use Disorders Identification Test at ages 18, 20, 22, 24 and 27. Multilevel logistic regression for repeated measures was used to calculate the adjusted Odds Ratios (ORs). College students perceive their family's alcohol consumption as very low or nothing, while the perception of their own alcohol use or that of their friends is higher. Perceiving higher alcohol use among their siblings and friends increases the risk of BD for both sexes and RC for women. Living away from the parental home increases the risk of RC and BD. In conclusion, the perception of their friend's alcohol use at age 18-19 is the most influential variable in BD among both sexes and in RC among men throughout 10 years of follow-up. Parental alcohol consumption does not affect college student drinking patterns when friends and siblings are considered. Living with one's family acts as a protective factor. Preventive measures focused on young people should take a contextual approach and include those closest to them.

El consumo percibido por los jóvenes de sus allegados puede afectar a las expectativas respecto al consumo de alcohol y de este modo, a su propio consumo. El objetivo del estudio ha sido identificar la capacidad predictiva de la percepción de consumo de alcohol propio y de los allegados al inicio del periodo universitario, en los patrones de consumo observados a lo largo de 10 años de seguimiento. Se ha llevado a cabo un estudio de cohortes en universitarios en España (n=1.382). Consumo Intensivo de Alcohol (CIA) y Consumo de Riesgo de alcohol (CRA) se midieron con el Test de Identificación de los Trastornos debidos al Uso de Alcohol (AUDIT) a los 18, 20, 22, 24 y 27 años. Se calcularon las Odds Ratios (ORs) con regresión logística multinivel para medidas repetidas. Los universitarios percibían bajo o nulo consumo de alcohol de sus familiares y mayor de sus amigos. Percibir mayor consumo de sus hermanos y amigos aumentó el riesgo de CIA en ambos géneros y de CRA en mujeres. Vivir fuera del domicilio familiar aumentó el riesgo de ambos patrones. En conclusión, la percepción del consumo de alcohol de amigos a los 18-19 años resultó la variable más influyente para el CIA en ambos géneros y el CRA en mujeres a lo largo de 10 años de seguimiento. El consumo de alcohol de los padres al inicio del periodo universitario parece no afectar a los patrones de consumo practicados durante la juventud, una vez se ajusta por el consumo de amigos y hermanos. Vivir en el domicilio familiar actúa como factor protector. Las medidas preventivas en los jóvenes deben tener un enfoque contextual incluyendo a sus allegados.

Percepción del consumo de alcohol propio y de allegados en universitarios de primer curso como predictor del consumo a 10 años / Own and others’ perceived drinking among freshmen as predictors of alcohol consumption over 10 years

El consumo percibido por los jóvenes de sus allegados puede afectar a las expectativas respecto al consumo de alcohol y de este modo, a su propio consumo. El objetivo del estudio ha sido identificar la capacidad predictiva de la percepción de consumo de alcohol propio y de los allegados al inicio del periodo universitario, en los patrones de consumo observados a lo largo de 10 años de seguimiento. Se ha llevado a cabo un estudio de cohortes en universitarios en España (n=1.382). Consumo Intensivo de Alcohol(CIA) y Consumo de Riesgo de alcohol (CRA) se midieron con el Test de Identificación de los Trastornos debidos al Uso de Alcohol (AUDIT) a los18, 20, 22, 24 y 27 años. Se calcularon las Odds Ratios (ORs) con regresión logística multinivel para medidas repetidas. Los universitarios percibían bajo o nulo consumo de alcohol de sus familiares y mayor de sus amigos. Percibir mayor consumo de sus hermanos y amigos aumentó el riesgo de CIA en ambos géneros y de CRA en mujeres. Vivir fuera del domicilio familiar aumentó el riesgo de ambos patrones. En conclusión, la percepción del consumo de alcohol de amigos a los 18-19 años resultó la variable más influyente para el CIA en ambos géneros y el CRA en mujeres a lo largo de 10 años de seguimiento. El consumo de alcohol de los padres al inicio del periodo universitario parece no afectar a los patrones de consumo practicados durante la juventud, una vez se ajusta por el consumo de amigos y hermanos. Vivir en el domicilio familiar actúa como factor protector. Las medidas preventivas en los jóvenes deben tener un enfoque contextual incluyendo a sus allegados. (AU)

The alcohol use perceptions young people have of those close to them canaffect their expectations regarding alcohol and, thus, their own drinking. Weaim to identify the predictive ability of own and significant others’ perceiveddrinking at age 18-19 in the alcohol use patterns at 27-28. A cohort study wascarried out among university students in Spain (n=1,382). Binge Drinking(BD) and Risky Consumption (RC) were measured with the Alcohol UseDisorders Identification Test at ages 18, 20, 22, 24 and 27. Multilevel logisticregression for repeated measures was used to calculate the adjusted OddsRatios (ORs). College students perceive their family’s alcohol consumptionas very low or nothing, while the perception of their own alcohol use orthat of their friends is higher. Perceiving higher alcohol use among theirsiblings and friends increases the risk of BD for both sexes and RC forwomen. Living away from the parental home increases the risk of RC andBD. In conclusion, the perception of their friend’s alcohol use at age 18-19is the most influential variable in BD among both sexes and in RC amongmen throughout 10 years of follow-up. Parental alcohol consumption doesnot affect college student drinking patterns when friends and siblings areconsidered. Living with one’s family acts as a protective factor. Preventivemeasures focused on young people should take a contextual approach andinclude those closest to them. (AU)

Corrigendum: Neurocognitive effects of binge drinking on verbal episodic memory. An ERP study in university students.

[This corrects the article DOI: 10.3389/fphar.2023.1034248.].

Effects of Persistent Binge Drinking on Brain Structure in Emerging Adults: A Longitudinal Study.

Previous cross-sectional research has largely associated binge drinking (BD) with changes in volume and thickness during adolescence and early adulthood. Nevertheless, the long-term alcohol-related effects on gray matter features in youths who had maintained a BD pattern over time have not yet been sufficiently explored. The present study aimed to assess group differences both cross-sectionally and longitudinally [using symmetric percent change (SPC)] on several structural measures (i.e., thickness, surface area, volume). For this purpose, magnetic resonance imaging was recorded twice within a 2-year interval; at baseline (18-19 years) and a follow-up (20-21 years). The sample included 44 university students who were classified as 16 stable binge drinkers (8 females) and 28 stable controls (13 females). Whole-brain analysis showed larger insular surface area in binge drinkers relative to controls at follow-up (cluster-wise p = 0.045). On the other hand, region of interest (ROI) analyses on thickness also revealed a group by sex interaction at follow-up (p = 0.005), indicating that BD males had smaller right rostral middle frontal gyrus thickness than both control males (p = 0.011) and BD females (p = 0.029). Similarly, ROI-based analysis on longitudinal data showed a group by sex interaction in the right nucleus accumbens (p = 0.009) which revealed a decreased volume across time in BD males than in control males (p = 0.007). Overall, continued BD pattern during emerging adulthood appears to lead to gray matter abnormalities in regions intimately involved in reward processing, emotional regulation and executive functions. Notably, some anomalies varied significantly depending on sex, suggesting a sex-specific impact of BD on typical neurodevelopment processes.

Effects of binge drinking during adolescence and emerging adulthood on the brain: A systematic review of neuroimaging studies.

Binge drinking (BD) is a common pattern of alcohol consumption which is generating great concern because of its deleterious consequences. We selected 33 neuroimaging studies of healthy young binge drinkers (BDs) by following PRISMA guidelines. This review provides a comprehensive overview of the relationship between BD and neurocognitive anomalies reported across magnetic resonance studies. Moreover, this work is the first in which results of relatively new imaging techniques, such as resting-state functional connectivity (RS-FC) and neurite orientation dispersion and density imaging (NODDI), have been reviewed using a systematic procedure. We established strict inclusion criteria in order to isolate the various potential effects of BD on the adolescent brain. Two authors independently evaluated the methodological quality, assessing different aspects related to sample size, and statistical correction methods, which are of particular importance in neuroimaging studies. BD is associated with structural and functional anomalies in several cortical and subcortical brain regions intimately involved in the control and regulation of impulsive or risky behaviours, as well as in the processing of reinforcing stimuli.

Alcohol-related stimuli modulate functional connectivity during response inhibition in young binge drinkers.

Binge drinking is a pattern of intermittent excessive alcohol consumption that is highly prevalent in young people. Neurocognitive dual-process models have described substance abuse and adolescence risk behaviours as the result of an imbalance between an overactivated affective-automatic system (related to motivational processing) and damaged and/or immature reflective system (related to cognitive control abilities). Previous studies have evaluated the reflective system of binge drinkers (BDs) through neutral response inhibition tasks and have reported anomalies in theta (4-8 Hz) and beta (12-30 Hz) bands. The present study aimed to investigate the influence of the motivational value of alcohol-related stimuli on brain functional networks devoted to response inhibition in young BDs. Sixty eight BDs and 78 control participants performed a beverage Go/NoGo task while undergoing electrophysiological recording. Whole cortical brain functional connectivity (FC) was evaluated during successful response inhibition trials (NoGo). BDs exhibited fast-beta and theta hyperconnectivity in regions related to cognitive control. These responses were modulated differently depending on the motivational content of the stimuli. The increased salience of alcohol-related stimuli may lead to overactivation of the affective-automatic system in BDs, and compensatory neural resources of the reflective system will thus be required during response inhibition. In BDs, inhibition of the response to alcohol stimuli may require higher theta FC to facilitate integration of information related to the task goal (withholding a response), while during inhibition of the response to no-alcoholic stimuli, higher fast-beta FC would allow to apply top-down inhibitory control of the information related to the prepotent response.

Alcohol Consumption among Freshman College Students in Spain: Individual and Pooled Analyses of Three Cross-Sectional Surveys (2005, 2012 and 2016).

Objective: We aimed to evaluate changes in the prevalence of Heavy Episodic Drinking (HED) and Risky Consumption (RC) in freshman college students between 2005, 2012 and 2016; and to identify the explanatory variables of these patterns of consumption using individual and pooled analyses. Methods: A cross-sectional study involving 5260 students was carried out in Spain in 2005, 2012 and 2016. HED and RC were determined using the Alcohol Use Disorders Identification Test. Another questionnaire was used to measure parental education level and alcohol use, alcohol-related problems, age of onset of alcohol use and alcohol-related expectancies. Adjusted Odds Ratios (ORs) of RC and HED and their 95% Confidence Intervals were estimated using logistic regression. Results: An increase in the prevalence rates of HED and RC was observed among women during the three-study periods, nonetheless there was no statistically significant difference in the prevalence rates among men. High maternal educational level, living away from parental home, initiating drinking before the age of 15 and having positive expectancies about drinking are associated with higher prevalence of RC in both genders. High positive expectancies and early onset of alcohol use are associated with higher rates of HED among men and women. Students recruited in 2012 and 2016 are protected against RC in comparison to those recruited in 2005. Conclusions: The age of alcohol consumption onset is the most influencing factor on HED and RC for both genders in the three-study periods. Alcohol prevention campaigns targeting youth at early ages can reduce risky drinking behaviors.

Impacto en la población de la reducción de expectativas positivas sobre consumo de riesgo e intensivo de alcohol en jóvenes / Population impact of reducing alcohol positive expectations on risky consumption and heavy episodic drinking among young people

Las creencias implícitas o explícitas que tiene una persona sobre las consecuencias de su propio consumo conforman las expectativas con respecto al consumo de alcohol. A pesar de referirse a las consecuencias del autoconsumo, Miller et al. nos recuerdan que las expectativas de una persona con respecto al consumo de alcohol se crean incluso antes de iniciarse el consumo real (Miller, Smith y Goldman, 1990), probablemente generadas a partir de la observación y profundamente influenciadas por las normas culturales. La tenencia de expectativas positivas sobre el consumo de alcohol se ha relacionado con mayores niveles de consumo de alcohol y el mantenimiento de los mismos, mientras que el efecto contrario se ha encontrado para las expectativas negativas (Carey, 1995; Linden, Lau- Barraco y Milletich, 2014). (AU)

Expectations regarding alcohol consumption are the implicit or explicit beliefs that a person hason the consequences of his/her own consumption. Despite referring to the consequences ofself-consumption, Miller et al. remind us that a person’sexpectations regarding alcohol use are created even before the actual consumption has started (Miller, Smith &Goldman, 1990), probably generated from observationand deeply influenced by cultural norms. Having positiveexpectations regarding alcohol use has been related to higher levels of alcohol consumption, and the maintenanceof them, while the opposite effect has been found for negative expectations (Carey, 1995; Linden, Lau-Barraco &Milletich, 2014). (AU)

The Use of Non-Prescribed Prescription Drugs and Substance Use Among College Students: A 9-Year Follow-Up Cohort Study.

The use of non-prescribed prescription drugs (NPPD) is common in post-modern societies and a significant proportion of youth consume NPPD concomitantly to other drugs. We studied the prevalence of this consumption among university students in Spain, and its relationship to different patterns of alcohol, tobacco, and cannabis use. A cohort study among university students (n=1,380) (2005-2015) was carried out. Students completed self-administered questionnaires at initial (n=1,363, 98.7%), at 2 years (n=875, 75%) and 9 years of follow-up (n=415, 30.5%). Consumption of medicines (last 15 days), risky alcohol consumption (RC), heavy episodic drinking (HED), and tobacco and cannabis use were measured. Multilevel logistic regressions for repeated measures were generated using consumption of medicines with or without medical prescription as dependent variables. Prevalence of RC, HED, tobacco and cannabis had significant reductions during the follow-up. The use of NPPD increased over time, from 35.5% and 33.3% at 18 and 22 years old, respectively, to 49.6% at 27 years old. The highest rates were found among cannabis, tobacco, RC and HED users. For females, cannabis and RC constitute signitifant risk factors for use of NPPD. Conversely, for males, tobacco and cannabis were risk factors for such use of medicines. Later onset of alcohol consumption constitutes a protective factor for females. Our results reveal high prevalence of NPDD among university students. Those who consume NPPD are -at the same time- more likely to be alcohol, tobacco, and cannabis users than those who take medication under prescription. Preventive strategies should be reinforced and focused on this target population to decrease these high levels of poly-consumption.

Response Inhibition and Binge Drinking During Transition to University: An fMRI Study.

BACKGROUND: Binge Drinking (BD), a highly prevalent drinking pattern among youth, has been linked with anomalies in inhibitory control. However, it is still not well characterized whether the neural mechanisms involved in this process are compromised in binge drinkers (BDs). Furthermore, recent findings suggest that exerting inhibitory control to alcohol-related stimuli requires an increased effort in BDs, relative to controls, but the brain regions subserving these effects have also been scarcely investigated. Here we explored the impact of BD on the pattern of neural activity mediating response inhibition and its modulation by the motivational salience of stimuli (alcohol-related content). METHODS: Sixty-seven (36 females) first-year university students, classified as BDs (n = 32) or controls (n = 35), underwent fMRI as they performed an alcohol-cued Go/NoGo task in which pictures of alcoholic or non-alcoholic beverages were presented as Go or NoGo stimuli. RESULTS: During successful inhibition trials, BDs relative to controls showed greater activity in the bilateral inferior frontal gyrus (IFG), extending to the anterior insula, a brain region usually involved in response inhibition tasks, despite the lack of behavioral differences between groups. Moreover, BDs displayed increased activity in this region restricted to the right hemisphere when inhibiting a prepotent response to alcohol-related stimuli. CONCLUSIONS: The increased neural activity in the IFG/insula during response inhibition in BDs, in the absence of behavioral impairments, could reflect a compensatory mechanism. The findings suggest that response inhibition-related activity in the right IFG/insula is modulated by the motivational salience of stimuli and highlight the role of this brain region in suppressing responses to substance-associated cues.

Densidad de los puntos de venta de alcohol y su consumo en jóvenes de Galicia / Alcohol outlet density and alcohol consumption in Galician youth

OBJETIVO: Valorar la influencia que la densidad de los puntos de venta y los de venta y consumo de alcohol ejercen sobre los patrones de consumo de los/las jóvenes preuniversitarios/as de Galicia. MÉTODOS: Se ha llevado a cabo un análisis transversal de la cohorte de estudiantes de la Universidad de Santiago de Compostela (Cohorte Compostela 2016). Se calcularon las prevalencias de consumo para cada uno de los municipios de procedencia de los/las estudiantes de primer ciclo durante el año anterior al ingreso. Se valoró la asociación del consumo de riesgo de alcohol (CRA) y consumo intensivo de alcohol (CIA) con un modelo logístico, considerando como variables independientes la población del municipio, la densidad de locales de venta, la densidad de locales de venta y consumo de alcohol, y la densidad de ambos tipos de locales en el municipio. RESULTADOS: La prevalencia de CRA fue del 60,5% (interval de confianza del 95% [IC95%]: 58,4-62,5) y la de CIA de 28,5% (IC95%: 26,7-30,2). Se observó una gran variabilidad según el municipio de procedencia. El modelo logístico multivariante mostró que los municipios con una densidad de 8,42-9,34 de ambos tipos de locales por mil habitantes presentaban mayor riesgo de CRA (odds ratio [OR]:1.39; IC95%: 1,09-1,78) y de CIA (OR= 1,29; IC95%: 1,01-1,66). CONCLUSIÓN: Estos datos sugieren la importancia de incluir la información del entorno al estudiar el consumo de alcohol. Conocer mejor el entorno podría ayudar a plantear políticas que fomenten en la población conductas más saludables

OBJECTIVE: To assess the influence that alcohol outlet density, off- and on-alcohol premises, and alcohol consumption wield on the consumption patterns of young pre-university students in Galicia (Spain). METHOD: A cross-sectional analysis of a cohort of students of the University of Santiago de Compostela (Compostela Cohort 2016) was carried out. Consumption prevalence were calculated for each of the municipalities from the first-cycle students' home residence during the year prior to admission. The association with risky alcohol consumption (RC) and binge-drinking (BD) was assessed with a logistic model considering as independent variables the municipality population, alcohol outlet density of off- premises, density of off- and on- premises and total density of both types of premises in the municipality. RESULTS: The prevalence of RC was 60.5% (95% confidence interval [95%CI]: 58.4-62.5) and the BD was 28.5% (95%CI: 26.7-30.2). A great variability was observed according to the municipality of provenance. The multivariate logistic model showed municipalities with a density of 8.42-9.34 of both types of premises per thousand inhabitants presented a higher risk of RC (odds ratio [OR]: 1,39; 95%CI: 1.09-1.78) and BD (OR: 1.29; 95%CI: 1.01-1.66). CONCLUSIONS: These data suggest the importance of including environmental information when studying alcohol consumption. Knowing our environment better could help plan policies that encourage healthier behaviour in the population

Binge Drinking, Cannabis Co-Consumption and Academic Achievement in First Year University Students in Spain: Academic Adjustment as a Mediator.

Little is known about how binge drinking or the combination of binge drinking and cannabis consumption affect academic achievement in students during the transition to university, or about the mechanisms that mediate this relationship. The purpose of this study was to evaluate the association between this pattern of alcohol/cannabis consumption and academic achievement, considering academic adjustment as a possible mediator. A total of 258 Spanish, first-year university students (145 females and 113 males), enrolled in undergraduate degree courses, were categorized into three groups on the basis of their patterns of alcohol/cannabis consumption: control, binge drinkers and co-consumers. The findings showed a significant effect of the combined binge drinking/cannabis consumption, but not of binge drinking alone, upon academic achievement and academic adjustment. Grade point average (GPA) and academic adjustment were lower in the co-consumers than in the other groups. Regarding the mediation effect, 34.33% of the impact of combined alcohol/cannabis use on GPA was mediated by academic adjustment. The combined consumption of alcohol and cannabis led to difficulties in adaptation to academic life, which in turn contributed to poorer performance at university. The implications of the findings are discussed.

[Alcohol outlet density and alcohol consumption in Galician youth]. / Densidad de los puntos de venta de alcohol y su consumo en jóvenes de Galicia.

OBJECTIVE: To assess the influence that alcohol outlet density, off- and on-alcohol premises, and alcohol consumption wield on the consumption patterns of young pre-university students in Galicia (Spain). METHOD: A cross-sectional analysis of a cohort of students of the University of Santiago de Compostela (Compostela Cohort 2016) was carried out. Consumption prevalence were calculated for each of the municipalities from the first-cycle students' home residence during the year prior to admission. The association with risky alcohol consumption (RC) and binge-drinking (BD) was assessed with a logistic model considering as independent variables the municipality population, alcohol outlet density of off- premises, density of off- and on- premises and total density of both types of premises in the municipality. RESULTS: The prevalence of RC was 60.5% (95% confidence interval [95%CI]: 58.4-62.5) and the BD was 28.5% (95%CI: 26.7-30.2). A great variability was observed according to the municipality of provenance. The multivariate logistic model showed municipalities with a density of 8.42-9.34 of both types of premises per thousand inhabitants presented a higher risk of RC (odds ratio [OR]: 1,39; 95%CI: 1.09-1.78) and BD (OR: 1.29; 95%CI: 1.01-1.66). CONCLUSION: These data suggest the importance of including environmental information when studying alcohol consumption. Knowing our environment better could help plan policies that encourage healthier behaviour in the population.

Electrophysiological Correlates of an Alcohol-Cued Go/NoGo Task: A Dual-Process Approach to Binge Drinking in University Students.

Binge drinking is a common pattern of alcohol consumption in adolescence and youth. Neurocognitive dual-process models attribute substance use disorders and risk behaviours during adolescence to an imbalance between an overactivated affective-automatic system (involved in motivational and affective processing) and a reflective system (involved in cognitive inhibitory control). The aim of the present study was to investigate at the electrophysiological level the degree to which the motivational value of alcohol-related stimuli modulates the inhibition of a prepotent response in binge drinkers. First-year university students (n = 151, 54 % females) classified as binge drinkers (n = 71, ≥6 binge drinking episodes, defined as 5/7 standard drinks per occasion in the last 180 days) and controls (n = 80, <6 binge drinking episodes in the last 180 days) performed a beverage Go/NoGo task (pictures of alcoholic and nonalcoholic drinks were presented according to the condition as Go or NoGo stimuli; Go probability = 0.75) during event-related potential recording. In binge drinkers but not controls, the amplitude of the anterior N2-NoGo was larger in response to nonalcohol than in response to alcohol pictures. No behavioural difference in task performance was observed. In terms of dual-process models, binge drinkers may require increased activation to monitor conflict in order to compensate for overactivation of the affective-automatic system caused by alcohol-related bias.

Perceived Social Support from Significant Others among Binge Drinking and Polyconsuming Spanish University Students.

Sense of acceptance is conceived as a central component of perceived social support and is thought to be a key resilience factor for adjustment during transition to university. The current study examines how a binge drinking pattern of alcohol consumption and the co-consumption of binge drinking and cannabis in first-year university students are related to perceived acceptance from family, mother, father, and friends. The study sample consisted of 268 women and 216 men, of average age 18.25 years (SE = 0.01), enrolled in the first year of different degree courses at the University of Santiago de Compostela. Participants were classified in three groups (control, binge drinking, polyconsuming) on the basis of the Timeline Followback for alcohol and cannabis. Perceived sense of acceptance was measured using the Perceived Acceptance Scale. Analysis of the data revealed that perceived acceptance was lower in polyconsuming students than in the binge drinking and control groups (p < 0.05; with η2 ranging between 0.009 and 0.020). A curvilinear relationship between binge drinking and perceived acceptance from friends was identified. Social support should be considered in future investigations and interventions as a vulnerability marker for detrimental consequences of substance use and risk of consumption disorders, as well as adolescent maladjustment.

Heavy Drinking and Non-Medical Use of Prescription Drugs among University Students: A 9-Year Follow-Up.

Purpose: Investigations suggest non-medical use of prescription drugs (NMUPD) is associated with heavy drinking and polydrug use among university students. Our aim is to determine the prevalence of NMUPD among university students and to analyze its association with alcohol, tobacco, and cannabis use, and to study the role of the age of drinking onset. Methods: Cohort study among university Spanish students (n = 1382). Heavy drinking (HED) and risky consumption (RC) were measured with the Alcohol Use Disorders Identification Test. Questions related to tobacco and cannabis consumption were also formulated. NMUPD refers to sedative, anxiety, or pain medication intake within the last 15 days without medical prescription. All variables were measured at 18, 20, and 27 years. Multilevel logistic regression for repeated measures was used to obtain adjusted OR (odds ratios). We analyzed the results from a gender perspective. Results: Prevalence of NMUPD were higher in students who already partook in NMUPD at the beginning of the study. NMUPD in women at 27 is 3 times higher than at 18, while in men it is twice. Among females, RC (OR = 1.43) and cannabis consumption (OR = 1.33) are risk factors for NMUPD, while later onset of alcohol use (OR = 0.66) constitutes a protective factor. No significant differences were found for males. Conclusions: NMUPD is prevalent among university students. RC and early onset of alcohol use were associated with higher prevalence of NMUPD in females. The prevalence of NMUPD increased with age in both sexes. Strategies for reducing risky drinking and delaying onset of drinking should be provided for university students. Pharmacists and parents should be alerted to the risk of NMUPD.