RESUMEN
OBJECTIVE: To clarify the influence of the HLA-DRB1 locus on the susceptibility to rheumatoid arthritis and the production of anti-cyclic citrullinated peptide antibodies (anti-CCP) in a Portuguese population. METHODS: 141 patients with rheumatoid arthritis fulfilling the American College of Rheumatology 1987 revised criteria for rheumatoid arthritis were compared with 150 healthy controls. Human leucocyte antigen (HLA)-DRB1 locus genotyping was assessed by polymerase chain reaction reverse probing assays and sequence-specific primers. Anti-CCP antibodies were quantified by ELISA in patients with rheumatoid arthritis. Frequencies between groups were compared by the two-sided Fisher's exact test and considered significant if p<0.05. RESULTS: The HLA-DRB1*04 and HLA-DRB1*10 groups were highly associated with rheumatoid arthritis (p<0.001 and p = 0.031, respectively). High titres of anti-CCP antibodies were largely associated with the presence of HLA-DRB1*04/10. CONCLUSION: The well-recognised susceptibility alleles to rheumatoid arthritis, HLA-DRB1*04, were associated with rheumatoid arthritis in Portuguese patients. The relatively rare DRB1*10 was also associated with rheumatoid arthritis, as was described previously in other southern European countries. Both groups were associated with high anti-CCP titres, reinforcing its relevance to disease onset.
Asunto(s)
Artritis Reumatoide/inmunología , Autoanticuerpos/inmunología , Epítopos/inmunología , Antígenos HLA-DR/inmunología , Péptidos Cíclicos/inmunología , Adulto , Anciano , Anciano de 80 o más Años , Alelos , Artritis Reumatoide/genética , Estudios de Casos y Controles , Susceptibilidad a Enfermedades , Femenino , Genotipo , Cadenas HLA-DRB1 , Humanos , Inmunofenotipificación , Masculino , Persona de Mediana Edad , Oportunidad Relativa , Portugal , RiesgoRESUMEN
We studied the sensitivity of H. pylori to clarithromycin and metronidazole, as well as the sensitivity and specificity of H. pylori culture, urease test and histology on a sample of 166 Portuguese patients. We observed a prevalence of 5.8% resistance to clarithromycin and 60% resistance to metronidazole. The sensitivity and specificity for the diagnostic tests were: culture 98% and 100%, urease test 98% and 91%, histology 50% and 95%, respectively.
Asunto(s)
Antibacterianos/antagonistas & inhibidores , Claritromicina/antagonistas & inhibidores , Helicobacter pylori/efectos de los fármacos , Metronidazol/antagonistas & inhibidores , Biopsia , Farmacorresistencia Microbiana , Gastroscopía , Infecciones por Helicobacter/microbiología , Infecciones por Helicobacter/patología , Helicobacter pylori/aislamiento & purificación , Humanos , Pruebas de Sensibilidad Microbiana , Sensibilidad y Especificidad , Estómago/microbiología , Estómago/patologíaAsunto(s)
Rechazo de Injerto/inmunología , Supervivencia de Injerto/inmunología , Antígeno HLA-DR6/inmunología , Prueba de Histocompatibilidad , Trasplante de Riñón/inmunología , Complicaciones Posoperatorias/inmunología , Ciclosporina/administración & dosificación , Quimioterapia Combinada , Rechazo de Injerto/mortalidad , Rechazo de Injerto/prevención & control , Supervivencia de Injerto/efectos de los fármacos , Humanos , Tablas de Vida , Metilprednisolona/administración & dosificación , Complicaciones Posoperatorias/mortalidad , Complicaciones Posoperatorias/prevención & control , Prednisolona/administración & dosificación , Estudios RetrospectivosRESUMEN
PIP: Patterns in labor migration from the Mediterranean region to the European Community are described.^ieng
Asunto(s)
Emigración e Inmigración , Migrantes , Demografía , Países Desarrollados , Europa (Continente) , Población , Dinámica PoblacionalRESUMEN
To investigate the possible relation between the DR4 antigen and IgM rheumatoid factors (RF). 80 patients with rheumatoid arthritis were tested for 7 HLA-DR antigens and 38 HLA-A, B, C antigens, and compared with 66 normal controls. The DR4 antigen prevalence was 48.7% in the patients and 12.1% in the controls (p less than 0.001). Studying the relationship between the HLA-DR4 antigen and IgM, the genetic marker was present in 89.7% of 51 seropositive patients and in 39% of 29 seronegatives (p less than 0.00001). On the other hand we discovered a positive association between HLA-DR3 and antinuclear antibodies (p less than 0.01). These results suggest the existence of immune response genes in the major histocompatibility complex of humans.
