1.
ACS Omega
; 3(11): 16309-16313, 2018 Nov 30.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30533586
RESUMEN
An improved and high yielding three-step synthesis for the production of 2-trifluoromethyl-10-aminopropylphenothiazine (TAPP) using less hazardous and more inexpensive reagents, its coupling to Sepharose-4B resin, and its ability to purify calmodulin are described. The overall yield of TAPP, starting with 3-aminopropyl bromide hydrobromide and 2-(trifluoromethyl)phenothiazine, was 96%.