RESUMEN
OBJECTIVE: The present study assessed whether there is a correlation between hepatic artery resistive index (HARI) and increase of body mass index and hepatosteatosis grading in children with non-alcoholic fatty liver disease (NAFLD) reflecting hemodynamic effects of hepatosteatosis. METHODS: Thirty three healthy children [body mass index(BMI): mean+/- standart deviation(SD), min-max: 20.1+/-1.14(18.5-23.7), 33 overweight [BMI:25.1+/-2.2 (18.5-23.7)] and 66 obese [BMI:31.1+/-2(25.6-40)] adolescents were enrolled into the study. To search the relation of HARI with fatty liver degree, study subjects subdivided into groups according to their degree of fatty liver at ultrasonography(US). RESULTS: Increase of HARI was correlated with increase in BMI (p<0.0001, r=0.533). Increase of HARI was well correlated with increase in degree of fatty liver (p<0.0001, r=0.630). CONCLUSION: The present study results suggest that there are positive correlations of HARI with BMI and hepatosteatosis grade in obese children with NAFLD. HARI may be a candidate parameter to determine early alarming hemodynamic changes in hepatic tissue of obese children with fatty liver before development of severe stages NAFLD.
Asunto(s)
Hígado Graso/fisiopatología , Arteria Hepática/fisiopatología , Obesidad/fisiopatología , Resistencia Vascular , Adolescente , Índice de Masa Corporal , Niño , Hígado Graso/complicaciones , Femenino , Humanos , Masculino , Obesidad/complicaciones , Ultrasonografía DopplerRESUMEN
AIM: The aim of this study was to evaluate the clinical, pathological and radiological survey of patients affected by Leigh syndrome. METHODS: Eleven patients with Leigh disease were evaluated at Dokuz Eylül University, School of Medicine, Department of Pediatric Neurology. All patients underwent neurological evaluation with detailed medical and family history. Muscle biopsy from quadriceps muscle, brain magnetic resonance imaging and brain magnetic spectroscopy were obtained. RESULTS: The patients were aged between 1 month and 8 years (mean age: 2.29+/-2.58 years). The most common presentation findings were psychomotor retardation and acute metabolic encephalopathy. All patients had elevated lactate in the blood and/or cerebrospinal fluid. Except in two patients, brain magnetic resonance imaging revealed abnormal symmetrical lesions in the brainstem and basal ganglia. Brain magnetic resonance spectroscopy revealed abnormal lactate peak in all patients. The muscle biopsy of two patients showed cytocrom-c oxidase deficiency and measurement of respiratory chain complex in one patient revealed complex I and IV deficiency. One patient was found to carry mitochondrial T8993C mutation. CONCLUSIONS: There are no specific markers for Leigh disease which lead to extensive work-up. The disease should be considered in patients who present progressive neurologic symptoms involving brainstem and basal ganglia.
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Enfermedad de Leigh/diagnóstico , Niño , Preescolar , Femenino , Humanos , Lactante , Enfermedad de Leigh/diagnóstico por imagen , Enfermedad de Leigh/patología , Masculino , RadiografíaAsunto(s)
Mielitis Transversa/diagnóstico , Enfermedad Aguda , Diagnóstico Diferencial , Progresión de la Enfermedad , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , Factores Inmunológicos/uso terapéutico , Lactante , Imagen por Resonancia Magnética , Masculino , Debilidad Muscular/etiología , Mielitis Transversa/tratamiento farmacológico , Mielitis Transversa/epidemiología , Mielitis Transversa/etiología , Enfermedades Raras , Infecciones del Sistema Respiratorio/complicaciones , Infecciones del Sistema Respiratorio/virología , Factores de Riesgo , Resultado del Tratamiento , TurquíaRESUMEN
Human Echinococcus infection still remains an important health problem in endemic regions. Herein, we report a 5-year-old boy with hydatid disease who has spleen, lung, kidney and liver involvement simultaneously. To our knowledge, there is no pediatric case with hydatid disease in the literature reporting simultaneous involvement of spleen, kidney, liver and lungs as in our case.
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Equinococosis Hepática/tratamiento farmacológico , Equinococosis Pulmonar/tratamiento farmacológico , Echinococcus granulosus/aislamiento & purificación , Enfermedades Renales/tratamiento farmacológico , Enfermedades del Bazo/tratamiento farmacológico , Animales , Antihelmínticos/administración & dosificación , Antihelmínticos/uso terapéutico , Antiinfecciosos/administración & dosificación , Antiinfecciosos/uso terapéutico , Preescolar , Equinococosis Hepática/diagnóstico por imagen , Equinococosis Hepática/parasitología , Equinococosis Pulmonar/diagnóstico por imagen , Equinococosis Pulmonar/parasitología , Ensayo de Inmunoadsorción Enzimática , Humanos , Enfermedades Renales/diagnóstico por imagen , Enfermedades Renales/parasitología , Masculino , Enfermedades del Bazo/diagnóstico por imagen , Enfermedades del Bazo/parasitología , Tomografía Computarizada por Rayos X , Resultado del TratamientoRESUMEN
Solid pseudopapillary tumor (SPT) of the pancreas is a rare pancreatic tumor mostly seen in young women. We here report a twelve-year-old girl presenting with recurrent attacks of pancreatitis. No history of a systemic disease, trauma, drug usage or infection was present. All other etiologic factors like familial, hypertriglyceridemia, hypercalcemia, cystic fibrosis, medications were excluded. On abdominal ultrasound a heterogeneous mass was noticed at the tail of pancreas. Computerized tomography and magnetic resonance imaging proved that the mass was cystic. The mass was surgically removed. The diagnosis was pancreatic solid cystic papillary epithelial neoplasm. Although acute pancreatitis due to SPT was exceptionally reported, this is the first description of SPT leading to recurrent pancreatitis especially in children.
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Cistoadenoma Papilar/patología , Neoplasias Pancreáticas/patología , Pancreatitis/etiología , Niño , Cistoadenoma Papilar/cirugía , Femenino , Humanos , Neoplasias Pancreáticas/cirugía , Pancreatitis/patología , Pancreatitis/cirugía , RecurrenciaRESUMEN
Most sternal fractures are transverse, and a lateral chest radiograph is diagnostic. We report a case of vertical sternal fracture that was not seen on plain radiographs but was revealed using computed tomography (CT). Thoracic CT with coronal reformatted images can also demonstrate sternal fracture lines, supernumerary synchondrosis, and costosternal joint abnormalities.
Asunto(s)
Fracturas Óseas/diagnóstico por imagen , Esternón/lesiones , Accidentes de Tránsito , Adulto , Humanos , Masculino , Esternón/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
Nitric oxide (NO) molecules have one of the most important roles in the pathogenesis of multiple sclerosis (MS). It has been stated that a continuous and high concentration of NO metabolites in CSF and in the serum of MS patients in relapse may cause toxic damage to myelin and oligodendroglia. The aim of this study was to investigate whether NO is a marker of disease activity and is correlated with other disease activity markers such as active lesions on brain magnetic resonance imaging (MRI) and increased immunoglobulin G (IgG) index. Cerebrospinal fluid (CSF) and peripheral serum (PS) samples were taken from patients with definite MS (n = 24) during relapse and remission and from control subjects (n = 18). The Griess reaction was used to measure the NO metabolites, nitrite and nitrate in CSF and PS. Cranial MRI was carried out with triple dose (0,3 mmol/kg) gadolinium and the IgG index was determined. Nitrite and nitrate concentrations (NNCs) of CSF were 11.16 +/- 8.60 micromol/ml in relapse and 6.72 +/- 3.50 micromol/ml in remission, whereas in PS they were 12.89 +/- 7.62 micromol/ml during relapse and 12.35 +/- 6.62 micromol/ml during remission. In control subjects NNCs in CSF and PS were 7.42 +/- 2.81 micromol/ml and 4.37 +/- 1.63 micromol/ml respectively. NNCs in CSF during relapse period were significantly higher than those of both remission phase and control subjects (p = 0.000). Although serum NNCs did not differ in relapse and remission, they were still higher than normal controls. Validity analysis revealed that NNC measurement in CSF was 71 % specific and 66 % sensitive to disease activity. The most important result was the significant correlation of increased NNCs with the existence of active lesion in cranial MRI and an increase in IgG index (p < 0.05).In conclusion, these results add background data to assist in further outlining the possible role of NO in the pathogenesis of MS. Together with the other markers it may be used as an activity marker in relapses of MS.
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Esclerosis Múltiple/líquido cefalorraquídeo , Óxido Nítrico/líquido cefalorraquídeo , Adolescente , Adulto , Biomarcadores/líquido cefalorraquídeo , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/patología , Nitratos/líquido cefalorraquídeo , Nitritos/líquido cefalorraquídeo , Recurrencia , Estadísticas no ParamétricasRESUMEN
A case of transient neonatal hypoglycemia with patchy hyperechogenic white matter abnormalities in the frontal and parietooccipital lobes on cranial US is presented. An MRI examination revealed T1 and T2 shortening of the lesions in the occipital and frontal white matter. Follow-up cranial US demonstrated recovery of white matter changes in the patient with normal neurological outcome.
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Daño Encefálico Crónico/diagnóstico , Hemorragia Cerebral/diagnóstico , Ecoencefalografía , Hipoglucemia/diagnóstico , Imagen por Resonancia Magnética , Corteza Cerebral/patología , Ventrículos Cerebrales/patología , Femenino , Humanos , Recién Nacido , Recién Nacido Pequeño para la Edad Gestacional , PronósticoRESUMEN
Malignant vagal paraganglioma is very uncommon and the diagnosis of malignancy is made on the basis of presence of distant metastasis rather than the histological findings. We report angiography findings of metastatic cervical lymph nodes in a case of malignant vagal paraganglioma.
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Cuerpos Aórticos/diagnóstico por imagen , Angiografía Cerebral , Tumor Glómico/diagnóstico por imagen , Adulto , Angiografía de Substracción Digital , Cuerpos Aórticos/patología , Cuerpos Aórticos/cirugía , Diagnóstico Diferencial , Femenino , Tumor Glómico/patología , Tumor Glómico/cirugía , Humanos , Metástasis Linfática , Imagen por Resonancia MagnéticaRESUMEN
A 12-year-old male with subacute sclerosing panencephalitis is presented. Magnetic resonance imaging revealed basal ganglia involvement without white matter changes for several months. Basal ganglia changes are not infrequent in subacute sclerosing panencephalitis, but they tend to appear in advanced clinical stages. Prominent basal ganglia involvement may occur very rarely in subacute sclerosing panencephalitis. In our patient, serial magnetic resonance imaging demonstrated the involvement of white matter after 2 years of magnetic resonance imaging follow-up. In contrast with the neuroradiologic progression, our patient's clinical status remained stable.
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Enfermedades de los Ganglios Basales/diagnóstico , Imagen por Resonancia Magnética , Panencefalitis Esclerosante Subaguda/diagnóstico , Ganglios Basales/patología , Niño , Progresión de la Enfermedad , Estudios de Seguimiento , Humanos , MasculinoRESUMEN
Carotid-cavernous fistulas (CCF) are reported very rarely in childhood and their clinical course and prognosis are uncertain. We report a 9-year-old boy presented with left eye swelling, neck pain and headache. The MRI findings suggested a CCF with enlarged left superior ophthalmic vein. Ocular Doppler ultrasonography revealed enlarged left superior ophthalmic vein, and arterialization of Doppler wave form. The cerebral angiogram showed normal anatomy. Control Doppler examination findings supported the diagnosis of closure of fistula. The clinical and radiological findings of this unusual presentation are discussed.
Asunto(s)
Fístula Arteriovenosa/diagnóstico por imagen , Enfermedades de las Arterias Carótidas/diagnóstico por imagen , Seno Cavernoso/diagnóstico por imagen , Niño , Protección a la Infancia , Humanos , Imagen por Resonancia Magnética , Masculino , RadiografíaRESUMEN
OBJECTIVE: To determine the correlation between clinical status and 3D, fat-saturated contrast-enhanced MRI findings in assessing the response to treatment in patients with knee-joint involvement from juvenile rheumatoid arthritis (JRA). MATERIALS AND METHODS: Synovial hypertrophy, effusion, cartilage and epiphyseal status were scored using spin-echo (SE) T1-weighted, SE T2-weighted and contrast-enhanced, fat-suppressed 3D MRI in 42 knees of 21 patients. MRI findings were evaluated by scoring results and compared with the clinical scoring results. Progression, improvement and equivalence were analysed between 0-3 and 3-6 months, both clinically and by MRI. RESULTS: Fat-suppression imaging generated high contrast between cartilage, synovium, effusion and bone. Correlation coefficients according to progression, improvement and equivalent findings of months 1-3 and months 3-6 comparison of clinical and MRI scores were found to be 0.50 and 0.70, respectively. CONCLUSION: Contrast-enhanced 3D MRI with fat suppression provides good discrimination between synovial hypertrophy and fluid. Fat-suppressed imaging offers better contrast between cartilage and synovium. Long-term MRI follow-up of JRA improves direct follow-up of pathological changes and helps in modifying treatment regimens.
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Artritis Juvenil/diagnóstico , Aumento de la Imagen , Imagenología Tridimensional , Articulación de la Rodilla/patología , Imagen por Resonancia Magnética , Adolescente , Niño , Preescolar , Femenino , Estudios de Seguimiento , Humanos , MasculinoRESUMEN
The authors describe a patient with severe lower back and left leg pain in the early postoperative period after cardiac surgery. Radiologic examination revealed gas in the spinal epidural space at the level of L4-5. The pain could not be relieved with analgesics and the patient underwent lumber surgery after cardiac surgery. After decompression, the patient improved and was discharged with no symptoms.
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Puente de Arteria Coronaria , Enfermedad Coronaria/cirugía , Gases/efectos adversos , Dolor de la Región Lumbar/etiología , Complicaciones Posoperatorias/etiología , Espacio Epidural , Humanos , Dolor de la Región Lumbar/diagnóstico por imagen , Dolor de la Región Lumbar/cirugía , Vértebras Lumbares , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/cirugía , Tomografía Computarizada por Rayos XAsunto(s)
Arteria Carótida Interna , Fístula del Seno Cavernoso de la Carótida/diagnóstico , Angiografía de Substracción Digital , Arteria Carótida Interna/diagnóstico por imagen , Arteria Carótida Interna/cirugía , Fístula del Seno Cavernoso de la Carótida/cirugía , Angiografía Cerebral/métodos , Diagnóstico Diferencial , Humanos , Lactante , Masculino , Tomografía Computarizada por Rayos X , Ultrasonografía DopplerRESUMEN
Cerebral sinus thrombosis (CST) is known to be related to a number of underlying aetiologies including otitis media, trauma, pregnancy, birth control pills, tumours, malnutrition, dehydration, haematologic disorders and malignancy (Fishman, 2000; Raizer and Abbott, 2000). We present the case of a patient with breast cancer receiving the antioestrogen drug tamoxifen who developed CST. A 40-year-old female presented as an emergency with a 10-day history of headache and left sided weakness. On questioning her past medical history included a diagnosis of breast cancer 3 years ago treated by radical mastectomy and tamoxifen 20 mg daily. At the time of admission, neurologic examination revealed a mild left sided hemiparesis and a present Babinksi sign. Non-contrast enhanced tomography was normal. Magnetic resonance imaging (MRI) showed thrombosis in the superior sagittal sinus, right lateral sinus and jugular vein in addition venous infarction in the right temporal lobe was present (Figs 1a and b). Routine haematology and biochemistry was normal. Anticoagulation tests, antithrombin III, protein S and C levels were also found to be normal. She was treated with anticoagulation therapy and her hemiparesis improved within 3 days. Control MRI showed the resorption of the venous infarction and resolution of the thrombosis (Fig. 1c).
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Antineoplásicos Hormonales/efectos adversos , Trombosis Intracraneal/inducido químicamente , Tamoxifeno/efectos adversos , Adulto , Neoplasias de la Mama/tratamiento farmacológico , Femenino , HumanosRESUMEN
An 11-month-old patient with Sturge-Weber syndrome with the absence of facial angioma and normal mental development is presented. Noncontrast computed tomography revealed left parieto-occipital atrophy with heavy gyriform calcifications. Axial T(2)-weighed magnetic resonance imaging confirmed the presence of low-signal areas corresponding to the gyral calcifications evident on computed tomography. Contrast-enhanced T(1)-weighted axial and coronal images exhibited high signals in the left parieto-occipital cortical and subcortical areas, representing angiomatous malformations. The clinical appearance and pathologic features of the reported patient were compared with those of similar patients described in published reports.
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Angiomatosis/diagnóstico , Lóbulo Occipital/patología , Lóbulo Parietal/patología , Síndrome de Sturge-Weber/diagnóstico , Diagnóstico Diferencial , Electroencefalografía , Epilepsia/etiología , Neoplasias Faciales , Humanos , Lactante , Imagen por Resonancia Magnética , Masculino , Nevo , Síndrome de Sturge-Weber/patología , Síndrome de Sturge-Weber/fisiopatología , Tomografía Computarizada por Rayos XRESUMEN
Magnetic resonance imaging (MRI) appearance of fibromatosis colli has been reported in only two cases in the literature. We herein describe the MRI findings in a case of fibromatosis colli: the signal intensity of the fusiform mass on T2 weighted images was slightly less than on T1 weighted images, consistent with the presence of some fibrous tissue within the muscle mass.
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Fibroma/diagnóstico , Neoplasias de Cabeza y Cuello/diagnóstico , Imagen por Resonancia Magnética , Femenino , Humanos , LactanteRESUMEN
The accuracy of dynamic contrast enhanced magnetic resonance (MR) imaging in the differentiation of malignant and benign pelvic lesions during follow-up of patients with treated colorectal tumours was evaluated prospectively. 19 patients (11 men, 8 women; age range 35-70 years; mean 57 years) with suspected local recurrence of colorectal malignancy were evaluated with MR imaging. Dynamic MR imaging with axial Turbo-FLASH gradient echo imaging and bolus injection of contrast medium was performed. Dynamic images, each consisting of one slice in the same location, were acquired at 5, 10, 15, 20 and 30 s, and at 1, 2, 3, 4, 5 and 10 min. The maximum change in signal intensity (Emax), the acceleration rate of the time-intensity curve (TIC) and the ratio of the signal intensity of the lesions to the signal intensity of the iliac artery (SIL/SIA) were used as the enhancement parameters. The TIC and SIL/SIA ratio at 60 s were found to be valuable in the differential diagnosis; Emax had no significance in differentiating benign and malignant lesions. Sensitivity was 83% for each calculated parameter. SIL/SIA has the highest specificity and accuracy among the parameters.