Resilience, sleep quality and sleepiness in Peruvian medical students: a multicenter study.

Background: Resilience can mitigate the negative impact produced by the COVID-19 pandemic. Medical students endure significant academic stress, so adjusting to sudden changes can present greater mental health challenges. The aim is to identify the level and prevalence of resilience and to know what are the educational variables and is sleep quality associated with resilience. Methods: A cross-sectional study was conducted using an online questionnaire. The survey was elaborated in Google Forms and shared through social networks. The outcome was resilience, measured with the Connor Davidson Resilience Scale. Its association was assessed with sleep quality (measured with the Pittsburgh Sleep Quality Index), daytime sleepiness (measured with the Epworth Sleepiness Scale), and selected academic/sociodemographic variables. Generalized linear models were used to identify the association between the variables. Results: Of 1277 participants, 35.7% experienced high resilience. Poor sleep quality and sleepiness were present in 88.4% and 36.0% of students, respectively. High resilience was associated with good sleep quality (PR:1.56; 95%CI: 1.34 - 1.83; p-value<0.001), absent sleepiness (PR:1.59; 95%CI: 1.32-1.91; p-value<0.001), male sex (PR: 1.21; 95%CI: 1.05-1.39; p-value 0.006), working (PR:1.14), having family responsibilities (PR: 1.36; 95%CI: 1.09-1.70; p-value 0.005) and spending more than 6 hours studying (PR: 1.35; 95%CI: 1.17-1.54; p-value<0.001). Conclusion: 4 out of 10 students presented high levels of resilience. The development of resilience depended on multiple individual and sociodemographic factors. These findings are important to support universities in developing resilience-building measures and strategies that can be implemented to mitigate the adverse pandemic event.

[Prevalence and factors associated with eating disorders in Peruvian Human Medicine students in the context of the COVID-19 pandemic: a multicentre study]. / Prevalencia y factores del trastorno de conducta alimentaria en estudiantes de Medicina Humana del Perú en el contexto de la pandemia de COVID-19: estudio multicéntrico.

INTRODUCTION: Eating disorders (ED) are serious conditions that have diverse consequences, associated with high morbidity and mortality: Among the factors associated with their development are, being female, and stress, which increased during the pandemic, and was higher in medical students. Our objective was to identify the prevalence and factors associated with ED in medical students. METHODS: Cross-sectional study, conducted with an online questionnaire, between January 1 and 31, 2021, in 22 universities, using the Eating Disorder Scale (EAT-26) and the Family Communication Scale (FCS). Generalized logistic regressions were used to identify the association between variables. RESULTS: A total of 1224 participants were recruited, and the prevalence was 12.5%. Associated factors included a poor perception of health in 34.3%, having a family and/or social environment member with an eating disorder in 21.7%, and medium or low satisfaction with family communication in 57.3% and 34.9% respectively, in addition to the academic year, dieting, concern for body image and the perception of inadequate eating. CONCLUSIONS: Our results show that, in the context of the COVID-19 pandemic, 1-2 out of 10 Human Medicine students had an ED. The associated factors that influenced development of the condition included a fair or poor perception of health, the academic year completed, and medium or low satisfaction with family communication.

Human Papillomavirus, Cytomegalovirus Infection and P16 Staining in Breast Tumors from Peruvian Women.

OBJECTIVE: To evaluate the frequency distribution of viral infections in Peruvian Breast Cancer (BC) lesions and its association with clinicopathological features. Additionally, a prospective evaluation of p16 and Tumor-infiltrating lymphocytes (TIL) levels were performed for developing a comprehensive analysis. METHODS: Detection of high risk- human papillomavirus (HR- HPV) through qPCR was performed in 447 BC and 79 non-cancer frozen samples. Paired paraffin samples from 238 BC were stained with Human cytomegalovirus (HCMV) and p16 immunohistochemistry. TIL was calculated in 397 BC cases. RESULTS: HCMV was positive in 72.5%. HR- HPV was detected in 2.9% of BC and 1.3% of non-malignant samples. P16+ was found in 28.15% and median TIL percentage was 30. HR- HPV infection was associated with non-ductal histology (p=0.003) and p16+ (p=0.017). Positive P16+ was associated with higher T stage (p=0.022), grade (p=0.009), TIL level (p=0.002), and triple-negative phenotype (p=0.021). CONCLUSION: HCMV is frequent, but HR- HPV infection is unusual in Peruvian BC. P16+ is associated with HR- PVH infection, high TIL and aggressive features.

Valores de referencia del Senior Fitness Test en mujeres adultas mayores físicamente activas / Reference values of the Senior Fitness Test for physically active elderly women

Introducción: El proceso de envejecimiento en los adultos mayores puede conducir a la disminución de la condición física funcional. Por ello resulta importante su valoración para poder establecer programas de ejercicio físico que mejoren las capacidades físicas, así como la funcionalidad y calidad de vida en esta población. Objetivo: Establecer los valores de referencia de la condición física funcional en las mujeres físicamente activas pertenecientes a Centros Vida de la ciudad de Bucaramanga. Métodos: Estudio descriptivo transversal en 113 mujeres mayores entre 60-85 años. Se evalúo la condición física funcional con el Senior Fitness Test y medidas antropométricas de talla y peso. Los valores de referencia están en percentiles y distribuidos por rangos de edad. Resultados: Según los valores de referencia del Senior Fitness Test, las mujeres de nuestro estudio se encuentran por encima en los valores de fuerza de miembros inferiores y superiores. En la prueba de resistencia cardiovascular y flexibilidad en miembros inferiores y superiores se encuentran por debajo. En los valores de la prueba de agilidad el tiempo de ejecución es mayor. Conclusiones: Se observa una disminución en las capacidades físicas funcionales conforme avanza la edad, sin embargo, la capacidad física que menos disminuye es la fuerza(AU)

Introduction: The aging process may lead to a reduction of functional physical condition in the elderly. Its analysis is therefore necessary to implement physical exercise programs aimed at improving physical capacities, functionality and quality of life in this population. Objective: Establish the reference values for functional physical condition in physically active women from Life Centers in the city of Bucaramanga. Methods: A cross-sectional descriptive study was conducted of 113 elderly women aged 60-85 years. Functional physical condition was evaluated with the Senior Fitness Test and anthropometric measurements of height and weight. Reference values are expressed in percentiles and distributed by age ranges. Results: The women in our study are above the reference values of the Senior Fitness Test in upper and lower limb force. Upper and lower limb cardiovascular resistance and flexibility are below SFT reference values. Values for the agility test show a longer performance time. Conclusions: A reduction is observed in functional physical capacities as people grow older. However, force is the physical capacity that diminishes the least(AU)

Ecological risk assessment of current-use pesticides and biocides in soils, sediments and surface water of a mixed land-use basin of the Pampas region, Argentina.

The present study aimed to assess the ecological risk of 30 current-use agricultural pesticides and biocides in the soil, sediments and aquatic organisms of a mixed land-use basin located in the Depressed Pampas Region of Argentina. Risk Quotients (RQs) were used to evaluate the chronic risk in soil and aquatic organisms, while Toxic Units (TUs) were used to assess the acute risk in sediment-dwelling organisms and aquatic biota. Acetochlor, hydroxy-atrazine, glyphosate, AMPA, metolachlor, imidacloprid and tebuconazole were the only pesticide residues detected (>30%) and quantified in all the matrices evaluated. Glyphosate and AMPA showed the highest concentrations, being their mean and maximum levels 27.90-176.00 µg kg-1 and 270-712.50 µg kg-1 in soils, 8.28-32.0 µg kg-1 and 6.85-17.50 µg kg-1 in sediments, and 1.88-4.36 µg L-1 and 0.66-1.03 µg L-1 in surface water. The RQs in soils showed high chronic risk, mainly due to AMPA and imidacloprid. The TUs in sediments showed acute risk in dwelling organisms, mainly due to glyphosate and imidacloprid. RQs assessment showed a range of chronic risk levels according to the site/sampling event, with higher contribution of atrazine and its metabolites, and acetochlor, whereas TUs assessment showed no acute risk in aquatic biota. In contrast to Europe, in Argentina, there are no restrictions regarding the use of atrazine, acetochlor, imidacloprid and glyphosate to protect aquatic life. Thus, it is recommended that the current Argentine pesticide regulations should be modified to prevent ecological risk and protect ecosystems.

Ecological Risk Assessment (ERA) of pesticides from freshwater ecosystems in the Pampas region of Argentina: Legacy and current use chemicals contribution.

Agricultural production in the Pampas region is one of the most important economic activities in Argentina. However, the possible environmental effects related to the growth of this activity in the last years have not been studied enough. Particularly, the effects of pesticides mixtures are a topic of great concern both for society and regulatory authorities worldwide, given the possible additive and synergistic relationships between these chemicals and their possible effects on aquatic biota. Based on a concentration addition model, this study developed an Ecological Risk Assessment (ERA) of pesticides from freshwater ecosystems in the Pampas region. For this purpose, reported pesticides concentrations available in public bibliography and a Risk Quotients (RQs) approach were used. A cumulative risk map was established to display RQs for current use pesticides (CUPs) and legacy chemicals. The ΣRQs were calculated for 66 sites, using available reported measured environmental concentrations (MECs) and predicted no effect concentrations (PNECs) of pesticides. While ΣRQ for only CUPs resulted in a high and very high risk (ΣRQ > 1) for 29% of the sites, when legacy pesticides were incorporated this percentage reached the 41% of the sites, increasing significantly the absolute values of RQ. Herbicides like glyphosate and atrazine contributed considerably to the ΣRQCUPs while organochlorines were the major contributors for ΣRQs when legacy pesticides were incorporated. Moreover, some active ingredients (acetochlor, carbendazim and fenitrothion) which are approved for their use in Argentina but banned in EU showed high contribution to ΣRQCUPs. The present study is the first attempt to develop an ERA in surface water of the Pampas region of Argentina and it provides a starting point for a more comprehensive pesticides monitoring and a further risk assessment program.

Multi-criteria decision model for assessing groundwater pollution risk in the urban-rural interface of Mar del Plata City (Argentina).

In developing countries, conflict between the objectives of environmental policies and those focused on economic development, a low availability of human resources and infrastructure, and the lack of continuity and incentives, contribute to the inability to successfully implement environmental policies. Moreover, in these countries, population growth in the peri-urban areas has resulted in serious water pressures, poor water management, and severe non-point source pollution. The aim of this paper is to implement a procedure of aquifer pollution risk assessment for identifying priority areas in an urban-rural interface based on multi-criteria decision tools. In this sense, a multi-criteria decision model was designed, in terms of environmental and socio-economic criteria and sub-criteria relevant to water resource management, by using the software Criterium Decision Plus 4.0. This model was applied to the northwestern peri-urban area of Mar del Plata City, Argentina, which is embedded in the second most important fruit-horticultural belt of the country. Here, groundwater is the only source of water supply. The proposed decision model allowed establishing a ranking of priority areas for defining action guidelines in order to minimize the risk of pollution of the aquifer. Aquifer pollution hazard criterion mainly contributes to alternatives classified as very high priority whilst in the case of low and very low priority classes, social vulnerability criterion mostly influences the final results. The first alternatives will require an intervention in a short-term time horizon, and the last ones must be monitored in order to avoid their shift to a worse environmental condition.

Trastorno neurocognitivo leve en el climaterio con Evaluación Cognitiva Montreal / Mild neurocognitive disorder in the climacteric with Montreal Cognitive Assessment

Las mujeres en climaterio o transición menopáusica frecuentemente reportan quejas de memoria. El Estudio Esmeralda busca relacionar los Síntomas del Climaterio (SC) femenino en sus diferentes etapas: premenopausia (etapa -2, temprana de la transición menopáusica), perimenopausia (etapas -1 y +1ª, tardía de la transición menopáusica y temprana de postmenopausia) y postmenopausia (etapas +1b, +1c y +2, temprana de postmenopausia con tardía de postmenopausia), con posible deterioro del funcionamiento intelectual, que pudiera llevar a sospechar de Trastorno Neurocognitivo leve (TNCl). La muestra final quedó conformada por 100 mujeres con alto nivel de escolaridad entre 40 y 60 años de edad. Se realizó un estudio no experimental transversal con muestreo no probabilístico, utilizando la Evaluación Cognitiva Montreal (MoCA). Se obtuvieron resultados normativos en 43.27% de la muestra y Deterioro Cognitivo Leve (DCL) en 56.73%, encontrando diferencia de medias significativas al nivel 0.05 en las tres etapas de climaterio, resultando la mayor incidencia en perimenopausia, etapa de mayor disminución de estrógenos. Se concluye que cambios en la función intelectual, pueden estar asociados a variación hormonal. Se puede determinar TNCl en forma temprana, en busca de una atención primaria y puesta en marcha de reactivación de funciones intelectuales.

Women in the climacteric stage or menopausal transition, frequently report complaint in memory. Emerald Study search relate feminine climacteric syndrome in their different steps: premenopause (stage -2 early menopausal transition), perimenopause (stages -1 and +1a late menopausal transition and early postmenopause) and postmenopause (stages +1b, +1 c and +2 early postmenopause with late postmenopause), with a possible mild cognitive impairment, that carry on suspect of Mild Neurocognitve Disorder (mNCD). The final sample were 100 women with high schooling level between 40 and 60 years old. A nonexperimental, non-probability cross-sectional study was conducted through the Montreal Cognitive Assessment (MoCA). Normative results were obtained in 43.27% and mNCD in 56.73%, finding difference of significant means at the 0.05 level in the three stages of climacteric, resulting in the highest incidence in perimenopause, stage of greatest decrease in estrogen. It is concluded that changes in intellectual function may be associated with hormonal variation. mNCD can be determined early, in search of primary care and start-up of reactivation of intellectual functions.

Síntomas psicológicos en la transición menopáusica / Psychological symptoms in the menopausal transition

RESUMEN OBJETIVO: Conocer los síntomas en la Transición Menopáusica, mediante el autoinforme de la mujer, clasificado en tres grupos: 1er. Temprana de la Transición Menopáusica (etapa −2), 2°. Tardía de la Transición Menopáusica y Temprana de Postmenopausia (etapas −1 y +1a) y 3er. grupo Temprana de Postmenopausia con Tardía de Postmenopausia (etapas +1b, +1c y +2), analizando síntomas psicológicos. MATERIAL Y MÉTODO: Estudio no experimental transversal muestreo no probabilístico. Participantes 116 mujeres en un rango de edad entre 40 y 60 años con alto nivel de escolaridad, mediante la Escala de Clasificación en la Menopausia MRS, el Inventario de Ansiedad y Depresión de Beck. RESULTADOS: La muestra quedó conformada por un total de 100 mujeres con al menos un síntoma, con alto nivel de escolaridad y en el rango de edad de 40 a 60 años, agrupadas por etapa de Transición Menopáusica: 1er. grupo 36 mujeres, 2°. grupo 16 y 3er. grupo con 48 personas. Los síntomas psicológicos medidos con MRS son los más frecuentes en 41.60%; reportan queja subjetiva de pérdida de memoria 57% de las mujeres. Alfa Cronbach de .74 en MRS. CONCLUSIONES: Los síntomas psicológicos están presentes como un continuo a lo largo de la Transición Menopáusica, posiblemente debidos a la disminución de concentración de estrógenos, lo que conlleva en algunos casos al diagnóstico de Trastorno Neurocognitivo Leve.

ABSTRACT OBJECTIVE: To know the symptoms in the Menopausal Transition, through the self-report of the women, classified into three groups: 1st. Early Menopausal Transition (stage −2), 2nd. Late Menopausal Transition and Early Postmenopause (stages −1 and +1a) and 3rd. group Early Postmenopause with Late Postmenopause (stages +1b, +1 c and +2), analyzing psycological symptoms. MATERIAL & METHOD: Non-experimental transversal study, non-probabilistic sampling. The participants were 116 women between 40 and 60 years old with high schooling level, through The Menopause Rating Scale MRS, Beck Anxiety Inventory and Depression Inventory. RESULTS: The final sample consisted of 100 women with at least one symptom, with a high schooling level in the range of 40 to 60 years, grouped by Menopausal Transition stage: 1st. 36 women, 2nd. Group 16 and 3rd. group with 48. The psycological symptoms measured with MRS were the most frequently in 41.60%; report subjective complaint of memory loss 57% of women. Alfa Cronbach of .74 in MRS. CONCLUSION: Psychological symptoms are present as a continuum throughout the Menopausal Transition, possibly due to the decreased concentration of estrogen, which in some cases leads the diagnosis of Mild Neurocognitive Disorder.

Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy.

AIM: To investigate the survival impact of clinicopathological factors, including pathological complete response (pCR) and tumor-infiltrating lymphocytes (sTIL) levels according to subtypes, in breast cancer (BC) patients who received neo-adjuvant chemotherapy (NAC). METHODS: We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. sTIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preNAC core biopsy. pCR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, sTIL, pCR and survival were carried out using SPSSvs19. RESULTS: Median age was 49 years (range 24-84 years) and the most frequent clinical stage was IIIB (58.3%). Luminal A, Luminal B, HER2-enriched and (triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. pCR was observed in 11% and median percentage of sTIL was 40% (2%-95%) in the whole population. pCR was associated to Ct1-2 (P = 0.045) and to high sTIL (P = 0.029) in the whole population. There was a slight trend towards significance for sTIL (P = 0.054) in Luminal A. sTIL was associated with grade III (P < 0.001), no-Luminal A subtype (P < 0.001), RE-negative (P < 0.001), PgR-negative (P < 0.001), HER2-positive (P = 0.002) and pCR (P = 0.029) in the whole population. Longer disease-free survival was associated with grade I-II (P = 0.006), cN0 (P < 0.001), clinical stage II (P = 0.004), ER-positive (P < 0.001), PgR-positive (P < 0.001), luminal A (P < 0.001) and pCR (P = 0.002). Longer disease-free survival was associated with grade I-II in Luminal A (P < 0.001), N0-1 in Luminal A (P = 0.045) and TNBC (P = 0.01), clinical stage II in Luminal A (P = 0.003) and TNBC (P = 0.038), and pCR in TNBC (P < 0.001). Longer overall survival was associated with grade I-II (P < 0.001), ER-positive (P < 0.001), PgR-positive (P < 0.001), Luminal A (P < 0.001), cN0 (P = 0.002) and pCR (P = 0.002) in the whole population. Overall survival was associated with clinical stage II (P = 0.017) in Luminal A, older age (P = 0.042) in Luminal B, and pCR in TNBC (P = 0.005). CONCLUSION: Predictive and prognostic values of clinicopathological features, like pCR and sTIL, differ depending on the evaluated molecular subtype.

Las Emociones en Niños con Síndrome de Asperger / Emotions on Asperger's Syndrome

Las peculiaridades que presentan las personas con Síndrome de Asperger (SA) han sugerido el abordaje del mismo desde distintas perspectivas, por un lado, aspectos epistemológicos y cognitivos, por otro lado, neurobiológicos que tratan de describir este padecimiento. Dentro de las peculiaridades que se han descrito se encuentran aspectos cognitivos como la memoria, visuoespacialidad, habilidades sociales y emociones. Las emociones son esenciales para el desarrollo de habilidades sociales y se han encontrado peculiaridades al respecto en las personas con SA. De esta manera, el objetivo es revisar los hallazgos existentes sobre el estudio de las emociones en personas con Síndrome de Asperger que, a su vez, permitirán desarrollar posibles niveles de abordaje en el área clínica

The peculiarities presented among the Asperger's Syndrome have suggested approaching it from different perspectives; including epistemological, cognitive and neurobiological, pretending to explain this impairment. Among these peculiarities that have been described are cognitive aspects such as memory, visuospatial skills, social skills, and emotions. The emotion domain is basic to develop social abilities, and there are peculiarities found in the Asperger Syndrome's patients respect to this matter. According to this, the aim of this paper is to review the current findings respect to the emotions in people with the Asperger's Syndrome, as this allows developing tentative approaching levels within the clinic context.

Activo distribution and paraphernalia among "street children" / Distribución del activo y la parafernalia entre "niños de la calle"

Abstract Introduction The use of solvent inhalants has been documented in Mexico since the 1970s. Nevertheless, very little is known about the distribution and use dynamics among "street children". Few have ventured to study this issue because of the difficulties involved in working with marginalized, relatively inaccessible populations. Objective To analyze the distribution and consumption dynamics of activo, as it is known among street children in downtown Mexico City, and to document the paraphernalia and argot associated with these practices. Method This is a qualitative, descriptive, and interpretative study guided by the "Meeting Place" approach used by Hughes (1977), which has been adapted to Mexican population by Ortiz (1979). We also used ethnographic observation techniques and a social and immersion mapping of street spaces that allowed us to contact and relate to both informants and users. Results We identified activo distributors and storage areas; user groups were made up of men and women in a 7-3 ratio; physical and psycho-social characteristics of sellers and users, and some street argot and paraphernalia that allowed us to understand the dynamics of distribution and consumption. Discussion and conclusion The activo market is both captive and hidden; it is detrimental to the physical and mental health of street children, and is fostered by social exclusion and the lack of legislation.

Resumen Introducción El consumo de solventes inhalables se ha documentado en México desde la década de 1970; sin embargo, poco se sabe sobre la dinámica de distribución y consumo entre los "niños de la calle". Este tema se ha estudiado poco por las dificultades inherentes al trabajo con poblaciones marginales y de difícil acceso. Objetivo Analizar la dinámica de distribución y consumo del "activo" entre los "niños de la calle" de la zona centro de la Ciudad de México, así como documentar la parafernalia y el argot asociados a estas prácticas. Método Es un estudio de tipo cualitativo, de carácter descriptivo-interpretativo, guiado por el enfoque llamado "Lugares de Reunión" empleado por Hughes (1977) y adaptado a población mexicana por Ortiz (1979). También se emplearon técnicas etnográficas de observación, mapeo social e inmersión en los espacios de calle, que sirvieron para contactar y establecer un vínculo con los informantes y consumidores. Resultados Se identifican distribuidores y zonas de almacenamiento del activo; grupos de consumidores formados por hombres y mujeres en una proporción de 7 a 3; signos físicos y características psicosociales de vendedores y usuarios, así como el argot y parafernalia; lo que permite comprender la dinámica de distribución y consumo. Discusión y conclusión El mercado del activo es cautivo y oculto, deteriora la salud física y mental de los "niños de la calle" y es promovido además por la exclusión social y la falta de legislación.

Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy.

AIM: To determine influence of neoadjuvant-chemotherapy (NAC) over tumor-infiltrating-lymphocytes (TIL) in triple-negative-breast-cancer (TNBC). METHODS: TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays (TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS: Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response (pCR) (P = 0.0251) and outcome (P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections (ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. Post-NAC lesions with pCR had similar TIL levels than those without pCR (P = 0.6331). NAC produced a TIL decrease in full-face sections (P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival (DFS). Higher counts of CD3 in pre-NAC samples had longer overall-survival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR. CONCLUSION: TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related.

Funciones cognoscitivas en la orientación sexual / Cognitive functions in sexual orientation

En México existe poca evidencia respecto a cognición y orientación sexual, por lo tanto, el objetivo de esta investigación fue describir y comparar el desempeño cognoscitivo de atención, memoria y Funciones Ejecutivas (FE) de personas con diversas Orientaciones Sexuales. Participaron en total setenta y tres personas divididas (edad= 20.7+/-2.4)en cinco grupos: Hombres heterosexuales (H), Mujeres heterosexuales (M), Hombres Homosexuales (HH), Mujeres Homosexuales (MH) y Mujeres Bisexuales (MB). Evaluados individualmente con la prueba NEUROPSI Atención y Memoria. Los resultados (p<.05) mostraron diferencias en las subpruebas: funciones motoras en el cambio de la mano derecha, lectura congruente de Stroop, memoria en la etapa de codificación en las subpruebas de: memoria verbal en resencia, figura de Rey-Osterreith; asimismo en memoria lógica. Estos hallazgos indican que la evocación de información episódica de eventos o sucesos sin un vínculo autobiográfico y la codificación de información visoespacial tienen una influencia del sexo y la orientación sexual en esta muestra. Finalmente,los procesos de atención, memoria y FE en personas con diversa orientación sexual son normales.

In México there are few sexual orientation evidences related to cognition, therefore the aim of the study was to describe and compare the cognitive performance of attention, memory and executive functions in different sexual orientations. Total sample were seventy-three people divided (age=20.7+/-2.4) in five groups: heterosexual Men (M), heterosexual Women (W), Homosexual Men (HM), Homosexual Women (HW) and Bisexual Women (BW). Participants were individually assessed with the NEUROPSI Attention and Memory. The results (p<.05) showed differences in subtests: motor functions in the change of the right hand, congruent reading Stroop, encoding memory subtests: verbal memory resence, figure of Rey-Osterreith; retrieval logical Memory. These findings indicate that the retrieval of episodic event information (without an autobiographical link) and visuospatial coding information have an influence of sex and sexual orientation in this sample. Finally, attentional processes, memory and executive functions in people with different sexual orientation are normal.

El consumo de solventes inhalables en la festividad de San Judas Tadeo / Solvent inhalants use in the San Judas Tadeo feast

INTRODUCCIÓN: A San Judas Tadeo se le considera en México el patrón de las causas difíciles y desesperadas. Entre las creencias populares, se piensa que los "niños en situación de calle" se acogen a él para que les proteja y ayude a dejar de consumir drogas. OBJETIVO: Conocer el espacio social del uso de solventes inhalables en el marco del culto a San Judas Tadeo, a partir las prácticas y experiencias vividas con los niños en situación de calle de la zona del Centro Histórico de la Ciudad de México. MÉTODO: Se aplicó la metodología conocida como "Lugares de Reunión" propuesta por Hughes y adaptada por Ortiz, en un periodo de trabajo que abarcó del año 2011 a inicios del 2014. Se utilizó la observación no participante y la participante, así como la entrevista no estructurada a informantes no calificados, a calificados y a clave. RESULTADOS: Se documentaron 22 celebraciones del día de San Judas incluyendo dos fiestas anuales. Se entrevistaron a más de 300 usuarios de solventes inhalables y los resultados mostraron, entre otras cosas, que la edad promedio es de 25 años, que se desempeñan en subocupaciones informales y a la mendicidad en la vía pública. Todos consumen activo, pero con diferencias en la intensidad, con periodos alternantes de consumos altos y bajos y consideran que es prácticamente imposible dejar de consumirlo. DISCUSIÓN Y CONCLUSIÓN: El vínculo entre el consumo de inhalables y el culto a San Judas Tadeo en los niños en situación de calle, es ficticio.

INTRODUCTION: San Judas Tadeo is the patron saint of the difficult and desperate causes. Among popular beliefs, it is supposed that street kids pray to him and that he helps them quit the use of drugs. OBJECTIVE: Understanding the phenomenon of the misuse of solvents in the context of the san Judas Tadeo festivity among street children living in the Historical Center zone of Mexico City. METHOD: The "Meeting places" methodology developed by Hughes and adapted by Ortiz was applied from 2011 to 2014. Non-participant and participant observations, as well as unstructured and structured interviews to key informants were conducted. RESULTS: Twenty-two festivities of san Judas Tadeo were documented, and more than 300 solvent users were interviewed. The average age was 25 years. They were unemployed and begged for money. All of them were activo users which they administered with monas. They usually did it in binge patterns: use - non use, high - low use. DISCUSSION AND CONCLUSION: The link between the consumption of inhalants and the cult of St. Jude in children living in the streets is fictitious.

Temperamento y Carácter en Practicantes Mexicanos de Haidong Gumdo (Espada Coreana): Una Perspectiva Psicobiológica de la Personalidad / Temperament and Character in Mexican practitioners of Haidong Gumdo (Korean Sword): A Psychobiological Perspective on Personality

Resumen: Las artes marciales son una práctica común por las virtudes fisiológicas y psicobiológicas que poseen. El Haidong Gumdo es un arte marcial Coreana que se especializa en el uso de espadas y su técnica se basa en técnicas de combate. Los estudios de personalidad en las artes marciales son limitados con el modelo psicobiológico de Cloninger que incluye al temperamento el cual es heredable, independiente, homogéneo genéticamente y estable a través del tiempo y al carácter que indica diferencias individuales afectadas por factores sociales, aprendizaje y procesos de maduración. Se describen las diferencias en las dimensiones personalidad en practicantes mexicanos de Haidong Gumdo y personas sedentarias. Treinta Arte marcialistas y 28 controles fueron evaluados con el inventario de temperamento y carácter de Cloninger. Resultaron diferencias significativas entre el grupo de Haidong Gumdo y los controles en todas las subdimensiones de personalidad. En conclusión el practicante de Haidong Gumdo presenta un perfil característico vinculado con la filosofía- técnica aprendida, se apoya en el modelo psicobiológico de la personalidad de Cloninger que se fundamenta en evidencia genética y neuroanatómica, donde el temperamento es estable y constante mientras que el carácter cambia por las experiencias y es influenciado por factores ambientales y genéticos.

Abstract: Martial arts are a common practice by physiological and psychobiological virtues they possess. The Haidong Gumdo is a Korean martial art that specializes in the use of swords and technique is based on combat techniques. Studies of personality in martial arts are limited to the psychobiological model of Cloninger which includes the temperament which is heritable, independent, genetically homogeneous and stable over time and the character indicating individual differences affected by social, learning and processes maturation. Differences in personality dimensions Haidong Gumdo Mexican practitioners and sedentary people are described. Thirty martial artists and 28 controls were evaluated with inventory Cloninger temperament and character. There were significant differences between the group of Haidong Gumdo and controls in all sub-dimensions of personality. In conclusion Haidong Gumdo practitioner has a characteristic profile linked to technical philosophy-learned, rests on the psychobiological model of Cloninger's personality which is based on genetic and neuroanatomical evidence where temperament is stable and constant while the character changed by the experiences and is influenced by environmental and genetic factors.

El papel del cuerpo calloso en el procesamiento visoespacial / The role of the corpus callosum in the visuospatial processing

El procesamiento visoespacial es una función adaptativa del organismo que permite su interacción con los elementos que se encuentran en su medio ambiente. Se considera una función superior, ya que involucra sistemas de reconocimiento y de memoria, entre otros. Hasta el momento se ha descrito la participación de diversas estructuras cerebrales en el procesamiento de información visoespacial, por ejemplo, tradicionalmente se considera una especialización funcional por parte del hemisferio derecho; sin embargo aún existen muchas controversias con respecto a la participación de diversas áreas cerebrales tanto ipsilaterales como contralaterales en estás funciones visoespaciales. En el presente trabajo se discute el papel de la comunicación interhemisferica, y específicamente del papel que juega el cuerpo calloso en el procesamiento visoespacial. Se inicia con una descripción de las vías de procesamiento visoespacial desde el ojo hasta la corteza V1 y las conexiones anatómicas funcionales que se establecen a partir de ésta. Posteriormente se resume la estructura-función del cuerpo calloso y se revisan los trabajos que han reportado relaciones entre éste y la función visoespacial. Por último, se revisan algunas de las patologías neurológicas que cursan con afectación del cuerpo calloso y que se ha reportado en la literatura que afectan a la función visoespacial...

The visuospatial processing is an adaptive function of the organism that allows it to interact with the elements that are in their environment. It is considered a high-order function as it involves recognition systems, memory, among others. So far described the participation of various brain structures in processing visuospatial information, for example, is traditionally considered a functional specialization by the right hemisphere, but there are still many controversies regarding the participation of various brain areas, both ipsilateral and contralateral in the visuospatial functions. In this paper we discuss the role of interhemispheric communication, and specifically the role of the corpus callosum in visuospatial processing. It begins with a description of visuospatial processing pathways from the eye to the cortex V1 and the anatomical-functional connections are established from this. Later summarizes the structure-function of the corpus callosum and reviews the studies that have reported relationships between this and visuospatial function. Finally we review some of the neurological disorders that present with involvement of the corpus callosum and it has been reported in the literature that affect visuospatial function...

Valoración de la semántica en la comprensión de palabras orales / Assessment of the semantics in the oral understanding of words

Para reconocer y comprender palabras habladas, se debe combinar información acústico-fonética con conocimiento almacenado sobre los patrones de los sonidos de las palabras y su respectivo significante. En particular, los investigadores a lo largo de muchos años han tratado de determinar cómo el oyente es capaz de asignar significado a una señal acústica en continua variación, conjugando al mismo tiempo una colección de representaciones que genera la memoria con tal velocidad y precisión. Al respecto, dentro de la literatura neurocognitiva y neuropsicológica existen diversos modelos y posturas que intentan dar cuenta de la complejidad de dichos procesos. No obstante, la gran mayoría de los esquemas de exploración clínica comúnmente empleados reducen la comprensión de una palabra al reconocimiento automatizado de ésta. Esta revisión pretende enfatizar la relevancia en la exploración cotidiana del componente semántico como función primaria en la comprensión de palabras orales. Asimismo, se exponen tareas de evaluación del procesamiento léxico-semántico alternas a las de denominación.

To recognize and understand spoken words we should combine acoustic-phonetic information stored knowledge about the patterns of the sounds of words and their respective significant. In particular, researchers over many years have tried to determine how the listener is able to assign meaning to an acoustic signal in continuous variation, combining both a collection of memory representations generated with such speed and precision. In this regard, within the neurocognitive and neuropsychological literature there are many models and positions that attempt to account for the complexity of these processes. However, the vast majority of clinical examination schemes commonly employed reduce the understanding of a word to the automated recognition of it. This paper aims to emphasize the importance in the daily examination of the semantic component as a primary role in understanding spoken words. It also sets assessment tasks lexical-semantic processing alternative to naming.

Heterogeneidad intratumoral en cáncer de mama: reporte de dos casos y revisión de la literatura / Intratumoral heterogeneity in breast cancer: case report and literature review

El cáncer de mama (CM) es una enfermedad de gran complejidad. Presenta una gran variabilidad molecular, lo cual se puede observar cuando se comparan los tumores de distintos pacientes, dos regiones del mismo tumor, los ganglios regionales comprometidos versus el tumor primario y la metástasis a distancia versus la lesión primaria. Reportamos el caso de dos pacientes con CM con heterogeneidad en el fenotipo tumoral del tumor primario; el primer caso presentó dos tumores simultáneos de diferentes características dentro de la misma mama y el segundo caso mostró variación en el fenotipo del tumor luego del tratamiento neoadyuvante (TN). Así mismo, realizamos un análisis de la información publicada recientemente.

Breast Cancer (BC) is a complex disease. It shows notable molecular differences when we compare tumors from different patients, two intra-tumor distant regions, metastasis in regional lymph node versus primary lesion, and distant metastasis versus primary lesion. We report two cases of BC with tumor phenotype heterogeneity of the primary tumor. The first case developed two different simultaneous lesions inside the same breast and the second one developed a change in tumor phenotype after neoadjuvant treatment. Furthermore, we performed an evaluation of recently published information.

Lóbulos frontales y funciones ejecutivas en transexuales / Frontal Lobes and Executive Functions in Transsexuals

Una persona transexual se define como aquella que presenta una incongruencia entre el fenotipo físico y la identidad de género. Existen transexuales nacidos hombres pero con identidad de género de mujer. Se ha propuesto que uno de los orígenes de esta condición radica en los efectos que las hormonas esteroides sexuales tienen sobre el desarrollo cerebral a nivel prenatal y es posible que afecten las funciones cognitivas como las funciones ejecutivas. El objetivo fue evaluar funciones ejecutivas en transexuales hombre a mujer. Con la batería de lóbulos Frontales y Funciones Ejecutivas, se encontró que las Transexuales tuvieron una menor ejecución comparadas con los hombres en los puntajes totales de funciones ejecutivas y en los totales de corteza prefrontal orbitomedial. En las subpruebas de inhibición (Stroop) y Toma de decisiones (Juego de cartas del IOWA) las transexuales obtuvieron menores puntajes que los hombres y las mujeres. Estos resultados apoyan las evidencias que indican que las TH-M presentan una ejecución cognitiva lejana a su sexo de nacimiento y se propone un perfil cognitivo en las TH-M diferente al de los hombres y las mujeres.

Transsexualism is characterized by the development of a gender identity that is at variance with morphology of genitals and secondary sex characteristics. The origin of the transsexualism is not very clear, although some biological indicators as the prenatal androgenization seems to be one of the causes that predispose to the development of the sexual identity, as well as the cerebral anatomical differences between transsexuals and non transsexuals. Mental functions including executive functions are susceptible to be affected by sexual steroids hormones during development. The aim was to evaluate the cognitive profile in male to female transsexuals (M-FT) in absence of hormonal treatment with estrogens. With the battery of Frontal lobes and Executive Functions, transsexuals had a smaller execution compared with the men in the totals of executive functions and the totals of orbitomedial prefrontal cortex. In the sub-tests of inhibition (Stroop) and Decision making (letter Game of the IOWA) group transsexual had minor's scores than men and women. These results support the evidences that they indicate that the transsexuals display a distant mental execution to their sex of birth. We propose a cognitive profile in our transsexual group different from men and the women sets out.