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BACKGROUND: The aging population and increased disability prevalence in Spain have heightened the demand for long-term care. Informal caregiving, primarily performed by women, plays a crucial role in this scenario. This protocol outlines the CUIDAR-SE study, focusing on the gender-specific impact of informal caregiving on health and quality of life among caregivers in Andalusia and the Basque Country from 2013 to 2024. OBJECTIVE: This study aims to analyze the gender differences in health and quality of life indicators of informal caregivers residing in 2 Spanish autonomous communities (Granada, Andalusia, and Gipuzkoa; Basque Country) and their evolution over time, in relation to the characteristics of caregivers, the caregiving situation, and support received. METHODS: The CUIDAR-SE study uses a longitudinal, multicenter design across 3 phases, tracking health and quality of life indicators among informal caregivers. Using a questionnaire adapted to the Spanish context that uses validated scales and multilevel analysis, the research captures changes in caregivers' experiences amid societal crises, notably the 2008 economic crisis and the COVID-19 pandemic. A multistage randomized cluster sampling technique is used to minimize study design effects. RESULTS: Funding for the CUIDAR-SE study was in 3 phases starting in January 2013, 2017, and 2021, spanning a 10-year period. Data collection commenced in 2013 and continued annually, except for 2016 and 2020 due to financial and pandemic-related challenges. As of March 2024, a total of 1294 participants have been enrolled, with data collection ongoing for 2023. Initial data analysis focused on gender disparities in caregiver health, quality of life, burden, perceived needs, and received support, with results from phase I published. Currently, analysis is ongoing for phases II and III, as well as longitudinal analysis across all phases. CONCLUSIONS: This protocol aims to provide comprehensive insights into caregiving dynamics and caregivers' experiences over time, as well as understand the role of caregiving on gender inequality in health, considering regional variations. Despite limitations in participant recruitment, focusing on registered caregivers, the study offers a detailed exploration of the health impacts of caregiving in Spain. The incorporation of a gender perspective and the examination of diverse contextual factors enrich the study's depth, contributing significantly to the discourse on caregiving health complexities in Spain. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/58440.
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Cuidadores , Calidad de Vida , Humanos , Cuidadores/psicología , Calidad de Vida/psicología , España/epidemiología , Masculino , Femenino , Estudios Longitudinales , Factores Sexuales , Persona de Mediana Edad , Anciano , Encuestas y Cuestionarios , COVID-19/epidemiología , COVID-19/psicología , Disparidades en el Estado de Salud , AdultoRESUMEN
We aimed to investigate the impact of COVID-19 infection on maternal characteristics and obstetric and neonatal outcomes in a cohort of women in labor previously vaccinated who tested positive for SARS-CoV-2 infection, compared to aged-matched healthy controls. A retrospective case-control study was conducted among 66 women in labor. Clinical data were obtained from medical records. The attendance rates at childbirth and parenting classes, as well as the implementation of a birth plan, were significantly lower in the COVID-19 infection group (6.1% vs. 48.5%, <0.001; 6.1% vs. 33.3%, p = .005, respectively). Women with COVID-19 had a higher prevalence of prolonged postpartum hospital stay (33.3% vs. 9.1%, p = .016), and significantly higher prevalence of spontaneous preterm birth (27.3% vs. 1.09%, p = .006). Breastfeeding within the first 24 hr was also lower in women with COVID-19 (72.7% vs. 97.0%, p = .006). Maternal characteristics and neonatal outcomes are influenced by COVID-19 infection in vaccinated women. Complications include spontaneous preterm birth, prolonged postpartum hospital stay, and lack of breastfeeding within the first 24 hr. Childbirth education, parenting classes and implementing a birth plan may be associated with a decreased risk of COVID-19 infection.
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COVID-19 , SARS-CoV-2 , Humanos , Femenino , COVID-19/prevención & control , COVID-19/epidemiología , Embarazo , Adulto , Proyectos Piloto , Estudios Retrospectivos , Recién Nacido , Estudios de Casos y Controles , Complicaciones Infecciosas del Embarazo/epidemiología , Resultado del Embarazo/epidemiología , Nacimiento Prematuro/epidemiología , Vacunas contra la COVID-19 , Estudios de Cohortes , Vacunación/estadística & datos numéricos , Lactancia Materna/estadística & datos numéricosRESUMEN
Introduction: Icterus, if not detected, can affect the validity of results delivered by clinical laboratories, leading to erroneous results. This study aims to define bilirubin interference for some biochemical analytes and compare it with the manufacturer's data. Material and methods: Serum pools prepared with outpatients' samples were spiked with increasing bilirubin concentration (Merck, reference14370, Darmstadt, Germany) up to 513 µmol/L in order to evaluate the bias for the following biochemical analytes: creatinine (CREA), creatine kinase (CK), cholesterol (CHOL), gamma-glutamyltransferase (GGT), high-density lipoprotein cholesterol (HDL), and total protein (TP). For each analyte, six pools of different concentrations were prepared. Measurements were made employing Cobas 8000 analyser c702-502, Roche Diagnostics (Mannheim, Germany). This study employed a study procedure defined by the Spanish Society of Laboratory Medicine. Results: Obtained bilirubin concentrations producing a negative interference were 103 µmol/L for CHOL, 205 µmol/L for TP and 410 µmol/L for CK, but only for CK values less than 100 U/L. Bilirubin concentrations lower than 513 µmol/L do not produce interference for HDL and GGT. Finally, for the studied bilirubin concentrations, there is no interference for CREA higher than 80 µmol/L. Conclusion: Icterus interferences have been defined for each analyte, observing differences compared to data provided by the manufacturer. The evidence indicates that each laboratory should evaluate icteric interferences to ensure the high quality of the delivered results, thus benefiting patient care.
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Colesterol , Ictericia , Humanos , Suero , Bilirrubina , Creatinina , Creatina QuinasaRESUMEN
Introduction: In order to deliver high quality results, detection and elimination of possible analytical interferences, such as lipaemia, is crucial. The aim of this study is to evaluate the efficacy of high-speed centrifugation in eliminating lipaemic interference and to define own lipaemic index (LI) for the studied biochemical analytes. Materials and methods: Evaluated analytes were: albumin, alkaline phosphatase, alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), calcium, creatinine, gamma-glutamyltransferase (GGT), glucose, phosphates, total proteins, urea and total bilirubin. Those analytes and LIs have been analysed in duplicate in the Roche Diagnostics-c8000 analyser in samples centrifuged at 3000 rpm/10 minutes in the SL16 (Thermo Scientific, Waltham, USA) centrifuge and according to an own high-speed centrifugation protocol (12,900 rpm/15 minutes) in the MicroCL17R (Thermo Scientific, Waltham, USA) centrifuge. Lipaemia has been measured in each sample. The efficiency of high-speed centrifugation is verified by the Wilcoxon test (P < 0.05). In cases where significant differences are observed, our own LI is calculated. For ALT and AST, it is verified by McNemar test (P < 0.05). For creatinine, both Wilcoxon and McNemar test were applied. Results: There were statistically significant differences in analyte concentration before and after high-speed centrifugation for: albumin, creatinine, GGT, glucose, phosphates, urea and total bilirrubin. Own LI is calculated. McNemar test shows statistically significant diferences in the proportion of delivered results before and after high-speed centrifugation in ALT, AST and creatinine. Conclusions: This study confirms the efficacy of high-speed centrifugation protocol for all the considered analytes, excepting calcium, alkaline phosphatase and total proteins.
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Calcio , Hiperlipidemias , Humanos , Creatinina , Fosfatasa Alcalina , Centrifugación , Glucosa , Alanina Transaminasa , Albúminas , FosfatosRESUMEN
Objetivo: Comparar la composición y la funcionalidad de apoyo social de redes personales de personas cuidadoras de Granada y Gipuzkoa en función del sexo y la provincia. Método: Estudio transversal con metodología de análisis de redes personales. Se seleccionó una muestra de 66 personas cuidadoras segmentada por sexo en cada provincia. Se recogieron variables de composición, funcionalidad de apoyo y contenido relacional de 1650 contactos personales que conforman las redes estudiadas. Se utilizó el software EgoNet para la recogida, el análisis y la representación gráfica de las redes. Se midió la asociación de las características de la red con el sexo (de las personas cuidadoras y de las que componen sus redes) mediante la prueba de ji al cuadrado. Se analizaron los vínculos dentro de las redes. Resultados: Las redes de las personas cuidadoras de Granada están más feminizadas que las de Gipuzkoa. Las mujeres de Gipuzkoa cuentan con redes compuestas por menos familiares que las de Granada y con mayor número de relaciones entre las personas que las apoyan. Además, cuentan con más apoyo de hombres que de mujeres en todas las tareas analizadas, excepto en atención a la enfermedad. En ambas provincias, los hombres cuidadores presentan en sus redes más mujeres que ayudan en tareas específicas de cuidado que hombres. Solo en actividades fuera del hogar en Granada hay más hombres que ayudan que mujeres (76,1% vs. 57%; p = 0,026). Conclusión: Se aprecian diferencias según el sexo y entre provincias en la composición de las redes y en el modo en que hombres y mujeres reciben y ofrecen apoyo en el cuidado. (AU)
Objective: To compare the composition and functionality of social support of personal networks of caregivers of Granada and Gipuzkoa (Spain) according to sex and province. Method: Cross-sectional study with personal network analysis methodology. A sample of 66 caregivers segmented by sex in each province was selected. We collected variables of composition, functional and relational content in social support of 1,650 personal relationships of the networks studied. The EgoNet software was used for the collection, analysis and graphic representation of the networks. The association of the characteristics of the network with sex (of the caregivers and those who make up their networks) was measured, using Chi-square. The links within the networks were analyzed. Results: The networks of caregivers in Granada are more feminized than those in Gipuzkoa. The women of Gipuzkoa have less familiar networks than those of Granada and with a greater number of relationships among the people who support them. They also have more support from men than women in all the tasks analyzed, except in attention to the disease. In both provinces, male caregivers show in their networks more women who help in specific care tasks than men. Only in activities outside the home in Granada there are more men who help than women (76.1% vs. 57%; p = 0.026). Conclusion: Gender differences between provinces can be seen in the composition of the networks and in the way in which men and women receive and offer support in care. (AU)
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Humanos , Masculino , Femenino , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Cuidadores , Apoyo Social , España , Estudios Transversales , Atención Primaria de SaludRESUMEN
Technological changes have led to important advances in medical diagnoses and treatments that prolong the informal care process. Support from the personal network of informal caregivers is an undervalued resource and the changes that have occurred over time are unknown. The aim of this study was to analyze the changes in personal network support among informal caregivers and to examine the effect of these changes on self-perceived caregiver health, with a focus on differences between men and women and caregivers with high and low levels of burden We also investigated caregiver perceptions and explanations of changes to their support network (losses and additions and no change). Using a mixed-methods approach, data were obtained from 32 caregivers that were intentionally selected in Spain, who were interviewed twice with a one-year interval. In the quantitative phase, personal networks analysis was performed with Egonet software, which obtained data on the composition and functional content in social support from 1600 personal relationships (25 alters for each ego in the two waves). In the qualitative phase, semi-structured interviews were conducted in the two waves with a guide in order to explore the changes in informal support resources over time. The selected men with high levels of burden pointed out a loss of network support with more discouraging reports compared with the low-burden male caregivers. Furthermore, the selected women with low burden levels mentioned losses too; however, their reports were more positive. Women reported improved health, especially those with low burden scores in the first wave and those who did not lose support. Caregivers with a high initial burden and who lost support reported worse health, particularly men and women with a strong sense of duty toward care. Social support from personal networks is important for caregiver health and its effects are influenced by gender roles. Our findings could help by improving the relational and social capital of informal caregivers and adapting them to the new needs of formal home care systems.
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Cuidadores , Apoyo Social , Carga del Cuidador , Femenino , Servicios de Salud , Humanos , Masculino , Factores SexualesRESUMEN
Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs.
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(1) Background: The aim of this study was (i) to analyze problems faced by informal caregivers in three areas of their life: health, work and finances, and family and social relationships, (ii) to investigate the main determinants of these problems, and (iii) to explore differences between men and women. (2) Methods: The study population consisted of people aged ≥18 years living in a family home who were providing unpaid care to a dependent person in the same or another home and who were registered as caregivers with the Primary Health Care District of Granada or the Provincial Council of Gipuzkoa. Several logistic regression models were built to analyze the likelihood of caregivers experiencing health, work-related, or social problems as a result of their caregiving responsibilities. (3) Results: Informal female caregivers were more likely to experience problems attributed to caregiving than their male counterparts, particularly in the areas of health and work. Additional factors associated with an increased likelihood of problems were low perceived social support, performance of ungratifying tasks, and fewer years as a caregiver. (4) Conclusions: Informal caregivers in Spain face significant problems as a result of their caregiving duties, and the impact on men and women is different. Policies and interventions to mitigate the negative effects of unpaid caregiving should incorporate differential strategies to meet the specific needs of male and female caregivers in different caregiving contexts.
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Cuidadores , Apoyo Social , Adolescente , Adulto , Femenino , Identidad de Género , Humanos , Masculino , Problemas Sociales , EspañaRESUMEN
OBJECTIVE: To compare the composition and functionality of social support of personal networks of caregivers of Granada and Gipuzkoa (Spain) according to sex and province. METHOD: Cross-sectional study with personal network analysis methodology. A sample of 66 caregivers segmented by sex in each province was selected. We collected variables of composition, functional and relational content in social support of 1,650 personal relationships of the networks studied. The EgoNet software was used for the collection, analysis and graphic representation of the networks. The association of the characteristics of the network with sex (of the caregivers and those who make up their networks) was measured, using Chi-square. The links within the networks were analyzed. RESULTS: The networks of caregivers in Granada are more feminized than those in Gipuzkoa. The women of Gipuzkoa have less familiar networks than those of Granada and with a greater number of relationships among the people who support them. They also have more support from men than women in all the tasks analyzed, except in attention to the disease. In both provinces, male caregivers show in their networks more women who help in specific care tasks than men. Only in activities outside the home in Granada there are more men who help than women (76.1% vs. 57%; p=0.026). CONCLUSION: Gender differences between provinces can be seen in the composition of the networks and in the way in which men and women receive and offer support in care.
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Cuidadores , Apoyo Social , Estudios Transversales , Femenino , Humanos , Masculino , Atención al Paciente , EspañaRESUMEN
In the current pandemic situation, the literature urges to consider the gender approach to avoid deepening existing inequalities, as already happened in previous epidemics. This field note aims to describe an experience of application of gender analysis to the impact of the pandemic on the public health, carried out by the students and teachers of the Diploma of Gender and Health of the Andalusian School of Public Health-University of Granada. The activity consisted of a review of the literature on caregiving and its impact on health in the context of health crisis, a gender analysis of information and shared reflection and debate. The debate was grouped into around five reflections, in which the care was putted in the center. Every reflection was linked to the need to incorporate the gender approach in measures and specific actions.
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COVID-19 , Pandemias , Identidad de Género , Humanos , Salud Pública , SARS-CoV-2RESUMEN
OBJETIVO: Comparar las diferencias en la producción científica mundial sobre paternidad y maternidad (cantidad, momento de inicio y evolución temporal), conocer la distribución geográfica internacional de artículos sobre paternidad, y examinar la relación del índice de desarrollo humano (IDH) y del índice global de brecha de género (IGBG) con el número de artículos sobre paternidad. MÉTODO: Análisis descriptivo de artículos sobre paternidad y maternidad de la base Scopus desde 1788 hasta 2016, y análisis longitudinal de 2006 a 2015 de la relación entre la producción científica sobre paternidad, el IDH y el IGBG, mediante un modelo multinivel con distribución de Poisson y parámetro extra-Poisson. RESULTADOS: Hay cuatro veces menos artículos sobre paternidad que sobre maternidad. Los artículos sobre paternidad se desarrollaron de forma más tardía, y la mayoría (85%) se publicaron en las dos últimas décadas, cuando se incrementaron en mayor proporción que los de maternidad. Se constatan desigualdades geográficas, con América del Norte, Europa y Oceanía a la cabeza. Hay una relación estadísticamente significativa entre el incremento del IDH y el IGBG de los países del mundo y el aumento de los artículos sobre paternidad. CONCLUSIONES: El conocimiento en torno a la paternidad y la maternidad es desigual. Resulta imprescindible desarrollar un conocimiento no parcelado, no dividido y no reduccionista en el ámbito reproductivo. Es necesario visibilizar a los hombres como padres en la esfera científica, romper estereotipos de género e incorporar la corresponsabilidad en la crianza en las políticas y en las prácticas sociales como una cuestión de derecho fundamental
OBJECTIVE: To compare worldwide differences in scientific production on fatherhood and motherhood (quantity, start time and evolution over time), to determine the international geographic distribution of articles on fatherhood, and, to examine the relationship between the human development index (HDI), the global gender gap index (GGGI), and the number of articles on fatherhood. METHOD: Descriptive analysis of articles on fatherhood and motherhood from the Scopus database 1788-2016, and longitudinal analysis 2006-2015 of the relationship between scientific production on fatherhood, the HDI and the GGGI, by means of a multilevel model with Poisson distribution and extra-Poisson parameter. RESULTS: We observed four times fewer articles on fatherhood than on motherhood. Articles on fatherhood were developed later than those on motherhood, and most (85%) were published in the last two decades, when they increased more than articles on motherhood. We identified geographical inequalities, with North America, Europe and Oceania leading the way. There is a statistically significant relationship between the increase in the HDI and the GGGI in world countries, and the increase in the articles on fatherhood. CONCLUSIONS: Socially built knowledge around fatherhood and motherhood is unequal. It is essential to develop non-parcelled, undivided and non- reductionist knowledge in the reproductive field. It is necessary to make men visible as fathers in the scientific sphere, to break gender stereotypes, and to incorporate childrearing co-responsibility in social policies and practices as a matter of right
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Humanos , Comunicación Académica/estadística & datos numéricos , Paternidad , Desarrollo Humano , 57445 , Responsabilidad Parental , Indicadores de Ciencia, Tecnología e Innovación , Relaciones Interpersonales , Bases de Datos Bibliográficas/estadística & datos numéricos , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Masculinidad , 50334/estadística & datos numéricosRESUMEN
INTRODUCCIÓN: El objetivo del estudio es analizar la desigualdad de género en la producción científica de las revistas médicas españolas. MATERIAL Y MÉTODO: Estudio transversal de las principales revistas médicas españolas clasificadas por SCImago Journal & Country Ranking (n = 24) y sus publicaciones (n = 3.375) durante el año 2017. Se calculó la ratio mujer/hombre de autoría según revista y tipo de artículo. Los análisis bivariantes se desarrollaron con la variable dependiente tipo de artículo y las independientes: sexo, centro de trabajo y país de primeras y últimas autorías. Se realizaron modelos de regresión logística para el cálculo de las odds ratios ajustadas (ORa) con intervalos de confianza al 95% (IC 95%) del sexo de autoría según el tipo de artículo, mediante el programa estadístico R. RESULTADOS: El número total de firmantes fue 16.252 (44,2% mujeres, 53,9% hombres y 1,9% sexo no identificado). Las mujeres representaron el 46% de las primeras autorías y el 33,5% de las últimas. Las mujeres fueron primeras autoras de Editoriales con menor frecuencia que los hombres (ORa 0,39; IC 95% 0,30-0,51), pero con mayor frecuencia en los Originales (ORa 1,55; IC 95% 1,33-1,80). Las mujeres fueron últimas autoras con menor frecuencia en todos los tipos de artículos, especialmente en Editoriales (ORa 0,50; IC 95% 0,35-0,70). La ratio mujer/hombre del total de autoras y autores fue inferior a 0,80 en 10 de las 24 revistas analizadas (41,7%). CONCLUSIONES: Se demuestra la desigualdad de género en la autoría de las principales revistas médicas españolas en el año 2017, principalmente en las últimas autorías y los Editoriales
INTRODUCTION: Some studies have shown a lower female participation in scientific publications. The objective of this study is to analyse the gender inequalities in the main Spanish journals of medical publications. MATERIAL AND METHOD: Cross-sectional study of the main Spanish medical journals classified by SCImago Journal & Country Ranking (n = 24) and their publications (n = 3.375), during the year 2017. Women/men ratio in authorship was calculated for all journals and types of papers. Bivariate analyses were developed with the type of article as the dependent variable, and gender, institution, and country of the first and last authors as the independent variables. Logistic regression models were performed to calculate adjusted odds ratios (aOR) and their 95% confidence intervals (95% CI) of the types of papers according to authorship gender, institution, and country. The statistical program used was R. RESULTS: The total number of authors was 16,252 (44.2% women, 53.9% men, and 1.9% non-identified gender). Women represented 46% of the first authors and 33.5% of the last ones. Women were the first authors of Editorials less often than men (aOR 0.39; 95% CI 0.30-0.51), but more often in Originals (aOR 1.55; 95% CI 1.33-1.80). Women were the last authors with less frequency in all types of papers, especially in Editorials (aOR 0.50; 95% CI 0.35-0.70). The women/men ratio in authorship was less than 0.80 in 10 of 26 journals analysed (41.7%). CONCLUSIONS: These results show the gender inequalities in the authorship of the main Spanish medical journals in 2017, especially as first authors and Editorials
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Humanos , Masculino , Femenino , Autoria , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Publicaciones/estadística & datos numéricos , Estudios Transversales , Distribución por Sexo , EspañaRESUMEN
OBJETIVO PRINCIPAL: Analizar la prevalencia del sobrepeso en una muestra de mujeres Saharauis en relación a la imagen corporal. METODOLOGÍA: Muestra no aleatoria (n=210), mujeres residentes en campamentos de refugiados Saharauis de Tindouf, durante 2018. Se determinó el Índice de Masa Corporal (IMC) y se aplicó el cuestionario de la Silueta de Maganto y Cruz, para determinar el Índice de Distorsión y el de Insatisfacción de la imagen corporal. RESULTADOS PRINCIPALES: Un 60,47% de las mujeres presentaban un IMC superior a 25. El 92,4% de las mujeres se identifican con una silueta más delgada de la que les corresponde, mientras que el 40,5% de la muestra se sienten satisfechas de su imagen corporal. CONCLUSIÓN PRINCIPAL: La alta tasa de obesidad detectada en las mujeres no es motivo de insatisfacción con el cuerpo en las participantes. Los índices de distorsión e insatisfacción corporal sugieren que la figura de la mujer obesa encuentra una amplia aceptación social en la sociedad saharaui
OBJECTIVE: To analyse the prevalence of overweight in a sample of Saharawi women in relationship with their body image. METHODS: Intentional sample of 210 women living in Sahrawi refugee camps in Tindouf during 2018. The BMI was determined and then the Maganto and Cruz Silhouette questionnaire was applied to each, to determine the Distortion Index and the Body Image Dissatisfaction Index. RESULTS: 60.47% of women had a BMI of over 25. The 92.4% of women identify with a slimmer silhouette than corresponds to them. The 40.5% of the sample is satisfied with their body image. CONCLUSIONS: The high rate of obesity detected isdoes not related togenerate dissatisfaction with their body in the women that took part. The indices of distortion and dissatisfaction suggest social acceptance of the figure of an obese woman in Saharawi society
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Humanos , Femenino , Adulto , Sobrepeso/epidemiología , Imagen Corporal/psicología , Obesidad/epidemiología , Belleza , Sobrepeso/psicología , Obesidad/psicología , Índice de Masa Corporal , Encuestas y Cuestionarios , África del Norte/epidemiología , Estudios Transversales , Antropometría , Análisis de Varianza , Campos de RefugiadosAsunto(s)
Políticas Editoriales , Eficiencia Organizacional , Publicaciones Periódicas como Asunto , Difusión de la Información/métodos , América Latina , Publicaciones Periódicas como Asunto/economía , Publicaciones Periódicas como Asunto/ética , Publicaciones Periódicas como Asunto/normas , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Edición/ética , Edición/normas , Edición/estadística & datos numéricos , EspañaRESUMEN
INTRODUCTION: Some studies have shown a lower female participation in scientific publications. The objective of this study is to analyse the gender inequalities in the main Spanish journals of medical publications. MATERIAL AND METHOD: Cross-sectional study of the main Spanish medical journals classified by SCImago Journal & Country Ranking (n=24) and their publications (n=3.375), during the year 2017. Women/men ratio in authorship was calculated for all journals and types of papers. Bivariate analyses were developed with the type of article as the dependent variable, and gender, institution, and country of the first and last authors as the independent variables. Logistic regression models were performed to calculate adjusted odds ratios (aOR) and their 95% confidence intervals (95% CI) of the types of papers according to authorship gender, institution, and country. The statistical program used was R. RESULTS: The total number of authors was 16,252 (44.2% women, 53.9% men, and 1.9% non-identified gender). Women represented 46% of the first authors and 33.5% of the last ones. Women were the first authors of Editorials less often than men (aOR 0.39; 95% CI 0.30-0.51), but more often in Originals (aOR 1.55; 95% CI 1.33-1.80). Women were the last authors with less frequency in all types of papers, especially in Editorials (aOR 0.50; 95% CI 0.35-0.70). The women/men ratio in authorship was less than 0.80 in 10 of 26 journals analysed (41.7%). CONCLUSIONS: These results show the gender inequalities in the authorship of the main Spanish medical journals in 2017, especially as first authors and Editorials.
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Autoria , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Edición/estadística & datos numéricos , Estudios Transversales , Femenino , Humanos , Masculino , Distribución por Sexo , EspañaRESUMEN
The proximal 19p13.3 microdeletion/microduplication (prox19p13.3del/dup) syndrome is a recently described disorder with common clinical features including developmental delay, intellectual disability, speech delay, facial dysmorphic features with ear defects, anomalies of the hands and feet, umbilical hernia and hypotonia. While deletions are associated with macrocephaly, patients with duplications have microcephaly. The smallest region of overlap in multiple patients (113.5 kb) included three genes and one pseudogene, with a suggested major role of PIAS4 in determination of the phenotype and head size in these patients. Here, we refine the prox19p13.3del/dup with four additional patients: two with microdeletions, one with microduplication and one family with single-nucleotide nonsense variant in PIAS4. The patient with the PIAS4 loss of function variant displayed a phenotype quite similar to deletion patients -including the macrocephaly and many other core features of the syndrome. Patient's SNV was inherited from her mother who is similarly affected. Thus, our data indicate that PIAS4 is a major contributor to the proximal 19p13.3del/dup syndrome phenotype. In summary, we report the first patient with a pathogenic variant in PIAS4- and three additional rearrangements at the proximal 19p13.3 locus. These observations add further evidence about the molecular basis of this microdeletion/microduplication syndrome.
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Anomalías Múltiples/genética , Discapacidades del Desarrollo/genética , Discapacidad Intelectual/genética , Proteínas de Unión a Poli-ADP-Ribosa/genética , Proteínas Inhibidoras de STAT Activados/genética , Anomalías Múltiples/patología , Niño , Deleción Cromosómica , Duplicación Cromosómica/genética , Cromosomas Humanos Par 19/genética , Hibridación Genómica Comparativa , Discapacidades del Desarrollo/patología , Femenino , Humanos , Discapacidad Intelectual/patología , Masculino , Megalencefalia/genética , Megalencefalia/patología , Microcefalia/patología , FenotipoRESUMEN
No disponible
Asunto(s)
Humanos , Salud Mental/tendencias , Trastornos Mentales/epidemiología , 50207 , Salud Pública , Informes Anuales como Asunto , 57923/políticas , 57926/tendencias , Disparidades en el Estado de Salud , España/epidemiologíaRESUMEN
OBJECTIVE: To compare worldwide differences in scientific production on fatherhood and motherhood (quantity, start time and evolution over time), to determine the international geographic distribution of articles on fatherhood, and, to examine the relationship between the human development index (HDI), the global gender gap index (GGGI), and the number of articles on fatherhood. METHOD: Descriptive analysis of articles on fatherhood and motherhood from the Scopus database 1788-2016, and longitudinal analysis 2006-2015 of the relationship between scientific production on fatherhood, the HDI and the GGGI, by means of a multilevel model with Poisson distribution and extra-Poisson parameter. RESULTS: We observed four times fewer articles on fatherhood than on motherhood. Articles on fatherhood were developed later than those on motherhood, and most (85%) were published in the last two decades, when they increased more than articles on motherhood. We identified geographical inequalities, with North America, Europe and Oceania leading the way. There is a statistically significant relationship between the increase in the HDI and the GGGI in world countries, and the increase in the articles on fatherhood. CONCLUSIONS: Socially built knowledge around fatherhood and motherhood is unequal. It is essential to develop non-parcelled, undivided and non- reductionist knowledge in the reproductive field. It is necessary to make men visible as fathers in the scientific sphere, to break gender stereotypes, and to incorporate childrearing co-responsibility in social policies and practices as a matter of right.