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1.
Data Brief ; 42: 108064, 2022 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-35360045

RESUMEN

Pancreatic surgery is one of the surgeries burdened with the highest mortality and morbidity rate. This is due both to the aggressive biological nature of the pathology affecting the organ and to the technical difficulties associated with surgery. A further aspect on which research is focusing is represented by inflammation related to oncological pathology. Inflammation plays an important role in tumor progression, and growing evidence has confirmed that the fibrinogen-to-albumin ratio (FAR) is an important prognostic factor for overall survival (OS) in malignant tumors. Inflammatory markers had demonstrated also a role in the prediction of postoperative complication after pancreatic surgery. We speculate that FAR, as an easily available, cost-effective, and non-invasive prognostic indicator for pancreatic cancer patients, could help to identify patients at increased risk of postoperative pancreatic fistula (POPF). We therefore retrospectively analyzed the data relating to 117 pancreatic resections relating direct and indirect markers of inflammation with the incidence of post-operative complications.

2.
Nano Today ; 6(4): 339-354, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-37064764

RESUMEN

Electric tweezers utilize DC and AC electric fields through voltages applied on patterned electrodes to manipulate nanoentities suspended in a liquid. Nanowires with a large aspect ratio are particularly suitable for use in electric tweezers for patterning, assembling, and manipulation. Despite operating in the regime of extremely small particle Reynolds number (of order 10-5), electric tweezers can manipulate nanowires with high precision to follow any prescribed trajectory, to rotate nanowires with controlled chirality, angular velocity and rotation angle, and to assemble nanowires to fabricate nanoelectromechanical system (NEMS) devices such as nanomotors and nano-oscillators. Electric tweezers have also been used to transport in a highly controlled manner drug-carrying functionalized nanowires for cell-specific drug delivery.

3.
Ann Nutr Metab ; 53(3-4): 155-61, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-19011278

RESUMEN

BACKGROUND: Severe obesity is a major worldwide public health concern affecting 0.5-5% of the adult population. Adiponectin (Acpr30), an adipokine secreted from adipocytes, shows pleiotropic beneficial effects on obesity and related disorders. In this study, sequence analysis of Acpr30 gene (ACDC) was performed in a highly selected population of severely obese young adult patients from Southern Italy to investigate the associations between polymorphisms in the ACDC gene and the development of severe obesity concomitantly with other features of the metabolic syndrome. METHODS: The ACDC gene was analyzed by direct sequencing in the severely obese patients (n=220) and compared to healthy controls (n=116). The associations between the ACDC gene single-nucleotide polymorphisms (SNPs) and the levels of serum Acpr30 as well as the correlation with the presence of severe obesity jointly associated with other features of the metabolic syndrome were also investigated. Total serum Acpr30 concentrations were measured by the ELISA method. RESULTS: ACDC gene molecular screening revealed the presence of previously described SNPs and a new nucleotide alteration, c.355T>G, leading to a protein variant, p.L119V. Measurement of serum concentration of Acpr30 demonstrated lower levels of Acpr30 in the obese population compared to controls (30.5+/-28.3 vs. 43.9+/-35.7 microg/ml, p<0.01); in particular, significantly lower Acpr30 concentrations were observed in obese patients bearing c.-11377C>G SNP CG+GG genotypes than in those with CC genotype (22.9+/-20.5 vs. 33.1+/-29.4 microg/ml, p<0.05). CONCLUSIONS: Our results confirmed that low serum levels of Acpr30 are related to severe obesity and a difference in protein expression is associated with variants in ACDC gene promoter region.


Asunto(s)
Obesidad Mórbida/sangre , Obesidad Mórbida/genética , Polimorfismo de Nucleótido Simple , Adiponectina/sangre , Adiponectina/genética , Adulto , Índice de Masa Corporal , Estudios de Casos y Controles , Distribución de Chi-Cuadrado , Femenino , Genotipo , Humanos , Italia/epidemiología , Masculino , Síndrome Metabólico/sangre , Síndrome Metabólico/genética , Mutación , Polimorfismo de Nucleótido Simple/genética , Regiones Promotoras Genéticas
4.
J Hum Hypertens ; 16 Suppl 1: S93-9, 2002 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-11986904

RESUMEN

Angiotensin II receptor blockers represent a class of effective and well tolerated orally active antihypertensive drugs. Activation of AT(1) receptors leads to vasoconstriction, stimulation of the release of catecholamines and antidiuretic hormone and promote growth of vascular and cardiac muscle. AT(1) receptor blockers antagonise all those effects. Losartan was the first drug of this class marketed, shortly followed by valsartan, irbesartan, telmisartan, candesartan, eprosartan and others on current investigation. All these drugs have the common properties of blockading the AT(1) receptor thereby relaxing vascular smooth muscle, increase salt excretion, decrease cellular hypertrophy and induce antihypertensive effect without modifying heart rate or cardiac output. Most of the AT(1) receptor blockers in use controlled blood pressure during the 24 h with a once-daily dose, without evidence of producing tolerance to the antihypertensive effect and being with low incidence of side effects even at long term use. Monotherapy in mild-to-moderate hypertension controls blood pressure in 40 to 50% of these patients; when a low dose of thiazide diuretic is added, 60-70% of patients are controlled. The efficacy is similar to angiotensin-converting enzyme (ACE) inhibitors, diuretics, calcium antagonists and beta-blocking agents. AT(1) receptor blockers are specially indicated in patients with hypertension who are being treated with ACE inhibitors and developed side effects such as, cough or angioedema. The final position in the antihypertensive therapy in this special population and other clinical situations, such as left ventricular hypertrophy, heart failure, diabetes mellitus and renal disease, has to be determined in large prospective clinical trials, some of which are now being conducted and seem promising.


Asunto(s)
Antagonistas de Receptores de Angiotensina , Antihipertensivos/uso terapéutico , Hipertensión/tratamiento farmacológico , Animales , Antihipertensivos/farmacocinética , Humanos , Receptores de Angiotensina/metabolismo , Sistema Renina-Angiotensina/efectos de los fármacos
5.
ASDC J Dent Child ; 66(4): 280-2, 229, 1999.
Artículo en Inglés | MEDLINE | ID: mdl-10529873

RESUMEN

Fusion is a common dental finding. However, bilateral mandibular fusion of the primary incisors is a rare event, occurring with a prevalence of less than 0.02 percent. When all four permanent successors are present, this event becomes rarer still. Once fusion has been diagnosed, careful monitoring is required, since problems with exfoliation can occur, along with caries formation in the groove of the incompletely fused teeth.


Asunto(s)
Dientes Fusionados/diagnóstico por imagen , Incisivo/anomalías , Diente Primario/anomalías , Preescolar , Humanos , Incisivo/diagnóstico por imagen , Masculino , Mandíbula , Radiografía , Diente Primario/diagnóstico por imagen
6.
J Clin Microbiol ; 26(7): 1349-52, 1988 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-3137247

RESUMEN

The combination of radiometric methodology (BACTEC 12B) and probe technology for recovery and identification of mycobacteria was studied in two large hospital laboratories. The sediment from vials with positive growth indices was tested with DNA probes specific for Mycobacterium tuberculosis, Mycobacterium avium, and Mycobacterium intracellulare. The sensitivity of the radiometric method and the specificity of the probes resulted in a marked reduction in the time to the final report. Biochemical testing could be eliminated on isolates giving a positive reaction with one of the probes. Some 176 isolates of M. tuberculosis, 110 of M. avium, and 5 of M. intracellulare were recovered. Two-thirds of these isolates were detected and identified within 2 weeks of inoculation and the remainder was detected by 4 weeks, a reduction of 5 to 7 weeks to the final report.


Asunto(s)
Mycobacterium avium/aislamiento & purificación , Mycobacterium tuberculosis/aislamiento & purificación , ADN Bacteriano/análisis , Humanos , Mycobacterium avium/genética , Mycobacterium tuberculosis/genética , Hibridación de Ácido Nucleico , Valor Predictivo de las Pruebas , Radiometría , Juego de Reactivos para Diagnóstico
7.
J Clin Microbiol ; 26(4): 760-1, 1988 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-3366871

RESUMEN

Blood cultures processed with a lysis-centrifugation (Isolator) system and a radiometric (BACTEC 13A) broth system were compared for the recovery of Mycobacterium avium-M. intracellulare from patients with acquired immunodeficiency syndrome. Forty-nine isolates of M. avium-M. intracellulare were recovered by both systems, 9 were recovered by the Isolator system only, and 12 were recovered by the BACTEC system only. Average times to detection were 16 and 14 days for the Isolator and BACTEC systems, respectively. There was no significant difference between the two blood culture systems in sensitivity or time to detection.


Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Infecciones por Mycobacterium/diagnóstico , Mycobacterium avium/aislamiento & purificación , Infecciones Oportunistas/diagnóstico , Sepsis/diagnóstico , Sangre/microbiología , Humanos , Infecciones por Mycobacterium/etiología , Infecciones Oportunistas/etiología , Sepsis/etiología
8.
J Clin Microbiol ; 24(5): 708-11, 1986 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-3095369

RESUMEN

Disseminated mycobacterial infections are commonly seen in acquired immunodeficiency syndrome (AIDS) patients, and laboratory culture is the best method for diagnosing these infections. In addition to conventional agar media, we used BACTEC 12A (Johnston Laboratories, Inc., Towson, Md.) broth medium for culture. More isolates of Mycobacterium avium complex and Mycobacterium tuberculosis were recovered from 12A broth than from Lowenstein-Jensen or Middlebrook 7H11 agar. Also, the average detection time of these mycobacteria was the earliest with 12A broth. Stool examination has been helpful in diagnosing mycobacterial disease in AIDS patients, and in this study both acid-fast stain and culture of fecal material was necessary for efficient detection of mycobacteria. Another sensitive and practical method for detecting mycobacterial infections in patients with AIDS is the Isolator lysis-centrifugation system (Du Pont Co., Wilmington, Del.) which offers the advantage of quantitating the degree of mycobacteremia. Laboratories should be alerted to the possibility of mixed mycobacterial infection in patients with AIDS, and positive cultures should be repeatedly examined to detect coinfection with a slower-growing mycobacterium such as M. tuberculosis as well as M. avium complex.


Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Mycobacterium avium/aislamiento & purificación , Mycobacterium tuberculosis/aislamiento & purificación , Tuberculosis Pulmonar/diagnóstico , Tuberculosis/diagnóstico , Adulto , Bacteriuria , Medios de Cultivo , Heces/microbiología , Humanos , Masculino , Sistema Respiratorio/microbiología , Tuberculosis/complicaciones , Tuberculosis Pulmonar/complicaciones
9.
Ann Intern Med ; 105(2): 184-8, 1986 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-3729201

RESUMEN

Disseminated infection with Mycobacterium avium complex developed in 67 patients with the acquired immunodeficiency syndrome (AIDS) who were followed at Memorial Sloan-Kettering Cancer Center. Twenty-nine patients were treated with two or more antimycobacterial drugs for a mean of 6 weeks, and 7 patients received therapy for less than 1 month. Most patients received ansamycin, clofazimine, and ethionamide or ethambutol. Clinical improvement did not occur in treated patients, and microbiologic cure was never obtained. Mycobacterial bacteremia persisted in 24 of 26 treated patients. Colony counts of M. avium complex in sequential blood cultures decreased in 3 patients. Every autopsied patient with M. avium complex infection diagnosed before death, whether treated or not, had disseminated M. avium complex infection at autopsy.


Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Tuberculosis/etiología , Adolescente , Adulto , Antituberculosos/uso terapéutico , Niño , Preescolar , Quimioterapia Combinada , Humanos , Lactante , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Mycobacterium avium/efectos de los fármacos , Mycobacterium avium/aislamiento & purificación , Sepsis/microbiología , Tuberculosis/tratamiento farmacológico , Tuberculosis/microbiología
10.
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