RESUMEN
Indians of Guadeloupe have an especially high prevalence type 2 diabetes mellitus and a particular susceptibility to coronary heart disease. This case-control study conducted from September 15 to 24, 1997, analysed cardiovascular risk factors associated with diabetes and particularly dyslipidaemia in the Indian community of Guadeloupe. The 172 subjects included 86 diabetic patients of Indian origin and 86 age- and sex-matched non-diabetic controls. All subjects underwent a physical examination by the same observer. Obesity and hypertension were assessed, and fasting lipid concentrations were measured. The body mass index and waist-to-hip ratio were higher among patients than controls: 27.8 vs 25.1 Kg/m2 (p < 0.001) and 0.94 vs 0.90 (p < 0.001). Mean arterial systolic and diastolic pressures were higher for patients than controls (p < 0.001). Median HDL-cholesterol was 1.23 mmol/L for patients vs 1.4 mmol/L for controls (p < 0.001), and median triglycerides were 2.0 vs 1.3 mmol/L (p < 0.001). Mean apolipoprotein B was 1.40 +/- 0.36 g/L for patients vs 1.23 +/- 0.35 g/L for controls (p < 0.001). Our results show slight hypertension, central obesity, a lower plasma HDL-cholesterol concentration, a higher triglyceride concentration, and a higher apolipoprotein B concentration for diabetics. These data would appear to have important implications for the prevention of cardiovascular disease in this population.
Asunto(s)
Enfermedades Cardiovasculares/epidemiología , Complicaciones de la Diabetes , Adulto , Anciano , Anciano de 80 o más Años , Enfermedades Cardiovasculares/etiología , Estudios de Casos y Controles , Diabetes Mellitus/epidemiología , Angiopatías Diabéticas/epidemiología , Etnicidad , Femenino , Guadalupe/epidemiología , Humanos , Hiperlipidemias/complicaciones , Hiperlipidemias/epidemiología , Hipertensión/complicaciones , Hipertensión/epidemiología , Masculino , Persona de Mediana Edad , Obesidad , Factores de Riesgo , FumarAsunto(s)
Apolipoproteína A-I/sangre , Apolipoproteínas B/sangre , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Hiperlipidemias/clasificación , Algoritmos , Automatización , Colesterol/sangre , Quilomicrones , Humanos , Hiperlipidemias/sangre , Hiperlipidemias/diagnóstico , Análisis de Regresión , Triglicéridos/sangreRESUMEN
A Dominican neonate carrying a new abnormal hemoglobin, hemoglobin Roseau Pointe-à-Pitre alpha 2 beta 2(90)(F6) Glu----Gly, was detected in Guadeloupe during application of a cord blood screening program. This variant behaved in isoelectrofocusing as an Hb D, and displayed instability and low whole blood oxygen affinity. In the affected family it was present, either isolated, or in association with a beta+ thalassemia trait.