RESUMEN
BACKGROUND: The role of growth hormone (GH) in female reproduction has become a topic of increasing interest over the last decade. The replacement of GH for ovulation induction in women with hypopituitarism remains controversial. The role of GH in the human endometrium is still largely unknown. To the best of our knowledge, this study represents the first case report showing evidence that GH might play a role not only for ovulation induction, but also for the development of endometrial thickness in women with hypopituitarism. CASE: A 32-year-old hypophysectomized. woman, known for primary infertility, experienced multiple IVF/embryo transfer failures with inadequate endometrial development. The use of GH replacement therapy followed by conventional controlled ovarian hyperstimulation enabled endometrial development and better ovarian response to gonadotropins, leading to a successful ongoing pregnancy. CONCLUSION: The substitution with GH resulted in fewer days of ovarian stimulation, an acceptable endometrium, and a twin pregnancy delivered at 38 weeks' gestation.
Asunto(s)
Endometrio/efectos de los fármacos , Hormona del Crecimiento , Hipopituitarismo/tratamiento farmacológico , Adulto , Femenino , Hormona del Crecimiento/farmacología , Hormona del Crecimiento/uso terapéutico , Humanos , Embarazo , Resultado del EmbarazoRESUMEN
Se presenta el caso de un hombre de 30 años de edad con cuadro de 3 meses de evolución de adenomegalias, lesiones en piel y mucosas, síndrome de derrame pleural. La biopsia de piel y ganglio confirman infección por Paracoccidioides braziliensis. Presentó buena evolución al tratamiento con itraconazol.
This is the case of a 30-year old man with 3-month evolution of adenomegalies, skin and mucous lesions, syndrome of pleural effusion. Skin and lymph node biopsy confirm infection by Paracoccidioides braziliensis. The patient presented good evolution after treatment with itraconazole.
RESUMEN
Because of increasing migration, European countries are facing new pathogens and diseases, such as human herpes virus-8 (HHV-8). We assessed the prevalence of HHV-8 using a new ELISA test in 140 pregnant women delivering in Geneva (Switzerland). The prevalence of HHV-8 was 7.9% globally and up to 33.3% in the African subpopulation. Seropositive women were more frequently older (≥32 years old) than seronegative ones: 81.8% vs. 43%; p = 0.023, respectively. In conclusion, HHV-8 infection is present in European pregnant women. Attention should be given to the emergence of infectious diseases, such as HHV-8, and their impact on health in nonendemic countries.