RESUMEN
Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant's cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.
Asunto(s)
Antivirales/farmacología , Antivirales/uso terapéutico , Infecciones por Citomegalovirus/líquido cefalorraquídeo , Infecciones por Citomegalovirus/congénito , Ganciclovir/análogos & derivados , Adulto , Antivirales/administración & dosificación , ADN Viral/análisis , Femenino , Ganciclovir/administración & dosificación , Ganciclovir/farmacología , Ganciclovir/uso terapéutico , Humanos , Recién Nacido , Embarazo , Complicaciones Infecciosas del Embarazo , ValganciclovirRESUMEN
The aim of this study was to characterize the placental transfer of some environmental pollutants, and to explore the possibility of quantitatively predicting in utero exposure to these contaminants from concentrations assessed in maternal blood. Levels of toxic substances such as pesticides (p,p'-DDE, ß-HCH, and HCB), polychlorinated biphenyls (PCBs), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA) were determined in serum samples of 38 pregnant women living in Rome and in samples of cord blood from their respective newborns. The study was carried out in the years 2008-2009. PCB mean concentrations in maternal serum and cord serum ranged from 0.058 to 0.30, and from 0.018 to 0.064 ng/g · fw respectively. Arithmetic means of PFOS and PFOA concentrations in mothers and newborns were 3.2 and 1.4 ng/g · fw, and 2.9 and 1.6 ng/g · fw. A strong correlation was observed between concentrations in the maternal and the foetal compartment for PFOS (Spearman r = 0.74, p < 0.001), PFOA (Spearman r = 0.70, p < 0.001), PCB 153 (Spearman r = 0.60, p < 0.001), HCB (Spearman r = 0.68, p < 0.001), PCB 180 (Spearman r = 0.55, p = 0.0012), and p,p'-DDE (Spearman r = 0.53, p = 0.0099). A weak correlation (p < 0.1) was observed for PCBs 118 and 138.
Asunto(s)
Contaminantes Ambientales/sangre , Sangre Fetal/química , Exposición Materna , Intercambio Materno-Fetal , Embarazo/sangre , Adulto , Ácidos Alcanesulfónicos/sangre , Caprilatos/sangre , Monitoreo del Ambiente , Femenino , Fluorocarburos/sangre , Humanos , Hidrocarburos Clorados/sangre , Recién Nacido , Persona de Mediana Edad , Plaguicidas/sangre , Placenta , Circulación Placentaria , Análisis de RegresiónRESUMEN
Early onset sepsis (EOS) is a severe problem affecting very low birth weight (VLBW) infants and is associated with a threefold increased risk of mortality. Although advances in perinatal care have led to improved survival of VLBW infants over recent decades, survival without major neonatal morbidity has not increased. The authors reviewed the current literature on EOS, focusing on the peculiarities concerning risk factors, etiology, diagnosis, treatment and outcome in very low birth weight infants, and on the recent advances in the management of this condition.
