Asunto(s)
Inmunosupresores/uso terapéutico , Trasplante de Riñón , Pregnenodionas/uso terapéutico , Adolescente , Adulto , Recuento de Células , Niño , Preescolar , Femenino , Glucocorticoides/uso terapéutico , Humanos , Prueba de Cultivo Mixto de Linfocitos , Masculino , Cuidados Posoperatorios , Prednisona/análogos & derivados , Prednisona/uso terapéutico , Pregnenodionas/efectos adversos , Linfocitos T Citotóxicos/patologíaRESUMEN
1. The thymic hormone thymopoietin blocks neuromuscular transmission and was proposed (Goldstein, 1974) as a modulator of synaptic conductivity. 2. The cholinergic-induced inactivation of nicotinic receptor reconstituted into asolectin lipid vesicles was studied in the presence and in the absence of thymopentin, a synthetic pentapeptide corresponding to positions 32-36 of thymopoietin. 3. The present data show that thymopentin accelerates desensitization of the nicotinic acetylcholine receptor, supporting the aforementioned physiological role proposed for thymopoietin. 4. They also suggest that the hormone itself and/or a yet unidentified hormine-derived peptide fragment may act as an endogenous ligand for nicotinic acetylcholine receptor desensitization.