RESUMEN
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract. Changes in the microbiome and its interaction with the immune system are thought to play a key role in their development. The aim of this study was to determine whether metagenomic analysis is a feasible non-invasive diagnostic tool for IBD in paediatric patients. A pilot study of oral and faecal microbiota was proposed with 36 paediatric patients divided in three cohorts [12 with CD, 12 with UC and 12 healthy controls (HC)] with 6 months of follow-up. Finally, 30 participants were included: 13 with CD, 11 with UC and 8 HC (6 dropped out during follow-up). Despite the small size of the study population, a differential pattern of microbial biodiversity was observed between IBD patients and the control group. Twenty-one bacterial species were selected in function of their discriminant accuracy, forming three sets of potential markers of IBD. Although IBD diagnosis requires comprehensive medical evaluation, the findings of this study show that faecal metagenomics or a reduced set of bacterial markers could be useful as a non-invasive tool for an easier and earlier diagnosis.
Asunto(s)
Alphapapillomavirus/aislamiento & purificación , Papillomavirus Humano 6/aislamiento & purificación , Infecciones por Papillomavirus/complicaciones , Psoriasis/complicaciones , Verrugas/complicaciones , Acitretina/uso terapéutico , Corticoesteroides/efectos adversos , Corticoesteroides/uso terapéutico , Humanos , Inmunoglobulina A , Inmunosupresores/efectos adversos , Inmunosupresores/uso terapéutico , Queratolíticos/uso terapéutico , Masculino , Metotrexato/efectos adversos , Metotrexato/uso terapéutico , Persona de Mediana Edad , Infecciones por Papillomavirus/diagnóstico , Infecciones por Papillomavirus/virología , Paraproteinemias/complicaciones , Psoriasis/tratamiento farmacológico , Psoriasis/radioterapia , Inducción de Remisión , Terapia Ultravioleta , Verrugas/tratamiento farmacológico , Verrugas/virologíaRESUMEN
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Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Perineo/lesiones , Fibroma/etiología , Ciclismo/lesiones , Fascitis/diagnóstico , Diagnóstico DiferencialRESUMEN
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Asunto(s)
Humanos , Femenino , Anciano de 80 o más Años , Queratosis Seborreica/patología , Carcinoma de Células Escamosas/patología , Neoplasias Cutáneas/patologíaAsunto(s)
Carcinoma Verrugoso/diagnóstico , Neoplasias Faciales/diagnóstico , Neoplasias Cutáneas/diagnóstico , Anciano , Biopsia , Carcinoma Verrugoso/etiología , Carcinoma Verrugoso/patología , Carcinoma Verrugoso/cirugía , Sondas de ADN de HPV , Diagnóstico Diferencial , Neoplasias Faciales/etiología , Neoplasias Faciales/patología , Neoplasias Faciales/cirugía , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Inducidas por Radiación/diagnóstico , Neoplasias Inducidas por Radiación/patología , Neoplasias Inducidas por Radiación/cirugía , Neoplasias Cutáneas/etiología , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/cirugíaAsunto(s)
Eritema/etiología , Hidradenitis/etiología , Enfermedad de Hodgkin/complicaciones , Leucemia Neutrofílica Crónica/complicaciones , Síndromes Paraneoplásicos/complicaciones , Corticoesteroides/uso terapéutico , Anciano , Femenino , Humanos , Neoplasias Cutáneas/tratamiento farmacológico , Resultado del TratamientoRESUMEN
Juvenile acute pityriasis rubra pilaris (JAPRP) is a form of pityriasis rubra pilaris (PRP) with particular clinical characteristics and course. It is usually preceded by an infectious condition. We report a boy, initially thought to have Kawasaki disease, and subsequently diagnosed as having JAPRP, who made a satisfactory recovery. In this case, prior antibiotic treatment made it impossible to show the presence of any microorganism. However, the clinical characteristics of these patients and the similarities with other disorders involving the skin that are mediated by superantigens led us to think that these antigens may be involved in the development of this disease. Also, in view of the obvious differences between JAPRP and the other PRP, we suggest that, in the future this disorder may be considered a separate entity as a reactive exanthem.