Asunto(s)
Plaquetas/citología , Recuento de Plaquetas , Trombocitopenia/sangre , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Biopsia , Recuento de Células Sanguíneas , Médula Ósea/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Prospectivos , Curva ROC , Valores de Referencia , Estudios Retrospectivos , Sensibilidad y Especificidad , Trombopoyesis , Procedimientos Innecesarios , Adulto JovenRESUMEN
A 31-year-old man with mild hemophilia B developed a herniated disc treated with prednisolone for back pain. Surprisingly, hemostasis result tests performed before epidural infiltration were a normal activated partial thrombin time at 36.1â¯s. (normal range 27.9-37.7â¯s.) and factor IX (FIX) level 76% (normal range>70%), 13 days after prednisolone introduction. After a second control with a normal FIX level and a second genetic confirmation of hemophilia, no FIX concentrates was administered to perform the infiltration, which occurred without hemorrhagic complication. This new case of FIX normalization showed the necessity to have a perfect knowledge of patient's treatment to avoid misdiagnosis and a temporary normal hemostasis permit to perform epidural infiltration without replacement therapy.
Asunto(s)
Factor IX/metabolismo , Hemofilia B/sangre , Desplazamiento del Disco Intervertebral/sangre , Desplazamiento del Disco Intervertebral/terapia , Prednisolona/administración & dosificación , Adulto , Humanos , Masculino , Tiempo de Tromboplastina ParcialAsunto(s)
Anafilaxia , Cucurbita , Anafilaxia/diagnóstico , Anafilaxia/etiología , Anafilaxia/inmunología , Antígenos CD/metabolismo , Prueba de Desgranulación de los Basófilos , Basófilos/inmunología , Basófilos/metabolismo , Preescolar , Cucurbita/efectos adversos , Cucurbita/inmunología , Hipersensibilidad a los Alimentos/diagnóstico , Hipersensibilidad a los Alimentos/etiología , Hipersensibilidad a los Alimentos/inmunología , Humanos , Inmunoglobulina E/sangre , Masculino , Glicoproteínas de Membrana Plaquetaria/metabolismo , Pruebas Cutáneas , Tetraspanina 30RESUMEN
In four patients, all girls, aged 2, 3.5, 4 and 5 years, transient erythroblastopenia was diagnosed. The children were presented because of acute pallor. The haemoglobin levels were 2.8 to 5.0 mmol/l. After 3 weeks all patients had recovered or were recovering with increasing haemoglobin values. Three of the four patients needed one blood transfusion. In two patients there was evidence of a parvovirus B19 infection. Transient erythroblastopenia is mostly seen in patients aged 1-4 years. Most cases are postinfectious and there is evidence that human parvovirus B19 is responsible for many cases. In the very young child the differential diagnosis from Blackfan-Diamond anaemia may be very difficult.