RESUMEN
A total of 249 client-owned dogs with osteoarthritis were treated with firocoxib (5 mg/kg/day) or a positive control, etodolac (10-15 mg/kg/day), for 30 days. Veterinary examinations were performed on approximately days 0 (visit 1), 14 (visit 2), and 29 (visit 3). Based on defined noninferiority criteria, firocoxib and etodolac were comparable. Based on the magnitude of the change from baseline, improvement with firocoxib was significantly greater than with etodolac for lameness at a trot (visits 2 and 3) and for lameness at a walk, pain on manipulation, and range of motion (visit 3) (P < .05). In weekly owner evaluations, firocoxib provided significantly greater improvement than etodolac (P < .05) at each scoring.
Asunto(s)
4-Butirolactona/análogos & derivados , Antiinflamatorios no Esteroideos/uso terapéutico , Enfermedades de los Perros/tratamiento farmacológico , Osteoartritis/veterinaria , Sulfonas/uso terapéutico , 4-Butirolactona/efectos adversos , 4-Butirolactona/uso terapéutico , Animales , Antiinflamatorios no Esteroideos/efectos adversos , Enfermedades de los Perros/patología , Perros , Etodolaco/efectos adversos , Etodolaco/uso terapéutico , Femenino , Cojera Animal/tratamiento farmacológico , Masculino , Osteoartritis/tratamiento farmacológico , Osteoartritis/patología , Rango del Movimiento Articular/efectos de los fármacos , Rango del Movimiento Articular/fisiología , Seguridad , Sulfonas/efectos adversos , Resultado del TratamientoRESUMEN
OBJECTIVE: To determine whether topical application of a 10% fipronil solution would control signs of flea allergic dermatitis in cats housed under natural conditions. DESIGN: Multicenter open clinical trial. ANIMALS: 42 client-owned cats with flea allergic dermatitis. PROCEDURES: Study cats along with all other cats and dogs living in the same houses were treated with 10% fipronil solution topically on days 0, 30, and 60. Flea counts and clinical assessments were performed on study cats on days 0, 14, 30, 60, and 90. RESULTS: Percentage reductions in geometric mean flea counts on days 14, 30, 60, and 90, compared with day-0 geometric mean count, were 75, 73, 85, and 94%, respectively. Pruritus score was significantly improved at each examination after day 0, and pruritus was reduced or eliminated in 31 of 40 (78%) cats at the final examination. Similarly, scores for severity of miliary dermatitis and alopecia were significantly improved at each examination, except for alopecia score on day 14. Overall treatment efficacy, assessed on day 90, was excellent for 28 (70%) cats, good for 6 (15%), moderate for 3 (7.5%), and poor for 3 (7.5%). CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that monthly topical application of fipronil is effective for treatment of flea allergic dermatitis in cats housed under natural conditions.