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Bioorg Med Chem Lett
; 14(3): 667-71, 2004 Feb 09.
Artículo
en Inglés
| MEDLINE
| ID: mdl-14741265
RESUMEN
The nonsteroidal anti-inflammatory drugs flurbiprofen and ibuprofen were modified in an attempt to alter the kinetics of inhibitor binding by COX-1. Contrary to prior predictions, a halogen substituent is not sufficient to confer slow tight-binding behavior. Conversion of the carboxylate moiety of flurbiprofen to an ester or amide abolishes slow tight-binding behavior, regardless of halogenation state.