Implementation and Short-term Adverse Events of Anti-SARS-CoV-2 Vaccines in Inflammatory Bowel Disease Patients: An International Web-based Survey.

INTRODUCTION: Anti-SARS-CoV-2 vaccine clinical trials did not include patients with immune-mediated conditions such as inflammatory bowel disease [IBD]. We aimed to describe the implementation of anti-SARS-CoV-2 vaccination among IBD patients, patients' concerns, and the side effect profile of the anti-SARS-CoV-2 vaccines, using real-world data. METHODS: An anonymous web-based self-completed survey was distributed in 36 European countries between June and July 2021. The results of the patient characteristics, concerns, vaccination status, and side effect profile were analysed. RESULTS: In all 3272 IBD patients completed the survey, 79.6% had received at least one dose of anti-SARS-CoV-2 vaccine, and 71.7% had completed the vaccination process. Patients over 60 years old had a significantly higher rate of vaccination [p < 0.001]. Patients' main concerns before vaccination were the possibility of having worse vaccine-related adverse events due to their IBD [24.6%], an IBD flare after vaccination [21.1%], and reduced vaccine efficacy due to IBD or associated immunosuppression [17.6%]. After the first dose of the vaccine, 72.4% had local symptoms and 51.4% had systemic symptoms [five patients had non-specified thrombosis]. Adverse events were less frequent after the second dose of the vaccine and in older patients. Only a minority of the patients were hospitalised [0.3%], needed a consultation [3.6%], or had to change IBD therapy [13.4%] after anti-SARS-CoV-2 vaccination. CONCLUSIONS: Although IBD patients raised concerns about the safety and efficacy of anti-SARS-CoV-2 vaccines, the implementation of vaccination in those responding to our survey was high and the adverse events were comparable to the general population, with minimal impact on their IBD.

Attitudes of Medical Students in Malta Toward Psychiatry and Mental Illness.

OBJECTIVE: The study aimed to explore the attitudes of medical students in Malta toward psychiatry and mental illness. It looked at the effect of sex, clinical exposure, and experience with mental illness on students' attitudes. METHODS: A questionnaire containing the ATP 30 and MICA-2 scales was distributed to all medical students in Malta in a cross-sectional study. Factor analysis was followed by reliability testing using Cronbach Alpha. Factor scores were achieved using the regression method. The independent sample t test and the Mann-Whitney U test were used to check for relationships between factor scores and variable of interest. Following this, the means and medians of factor scores for each group were calculated and compared. RESULTS: Three hundred ninety-six students (51%) answered the questionnaire. Males had more positive attitudes toward psychiatry as a career choice (p = 0.01) and more positive attitudes toward the importance of psychiatry (p = 0.00). Those with clinical exposure to psychiatry had more negative attitudes toward the efficacy of psychiatry and psychiatrists (p = 0.00). Having experience with mental illness in some form was associated with decreased appeal in psychiatry as a career (p = 0.01 for personal experience, p = 0.01 for relatives, p = 0.00 for friends). CONCLUSIONS: The factor structures obtained using ATP 30 and MICA-2 scales in this study are different from those found in the original literature. Having undergone psychiatry rotations had no significant impact on the attitudes toward psychiatry as a career choice but led to more negative attitudes toward the efficacy of psychiatry and psychiatrists.

Beckwith-Wiedemann Syndrome Review: A Guide for the Neonatal Nurse.

Beckwith-Wiedemann syndrome (BWS) is the most common pediatric overgrowth syndrome. Features characteristic of the BWS phenotype include both physical attributes, such as macroglossia, abdominal wall defects, gigantism, nevus flammeus, visceromegaly, and mid-face hypoplasia, as well as biochemical abnormalities such as hypoglycemia. It is essential for the neonatal nurse to be able to recognize BWS in the patient's early years of life because of the increased frequency of medical complications, malformations, and the increased risk of embryonic malignancies. This article focuses on the presentation of BWS as an aid to early detection.