Association between waist circumference and magnesium and uric acid in indigenous Argentinean children living at high altitude.

BACKGROUND: Studies in adults show that central obesity increases the likelihood of Type 2 diabetes (T2DM). OBJECTIVE: To determine the association between waist circumference (WC) and non-traditional risk factors such as magnesium (Mg), phosphorus, and uric acid in indigenous children living at high altitudes. METHODS: A total of 354 (166 M) indigenous school children, aged 9.6 + 2.3 years, were enrolled in a cross-sectional study in November 2011. Central obesity was defined as WC > 90th percentile according to age and sex. Low Mg and phosphorus levels were defined as serum Mg <1.8 mg/dL and phosphorus <2.4 mg/dL . Hyperuricemia was defined as serum uric acid > 7 mg/dL. RESULTS: The prevalence of central obesity was 6.8% (24/354). None of the children had hyperuricemia or low P levels. HypoMg was identified in 21.7% (57/263). There was a significant association between WC (z-score) and Mg (r-015), uric acid (r0.28), phosphorus (r-0.30), HOMA-IR (r0.49), Triglycerides (r0.24), and HDL-C (r0.24). However, calcium, sodium, and potassium were not significantly associated with WC. As z-WC quartiles increased Mg and phosphorus levels significantly decreased, whereas uric acid levels increased. Multiple linear regression analysis showed that z-WC was associated significantly and directly with uric acid (B0.31), triglycerides (B0.004), and HOMA-IR (B0.35); and inversely with Mg (B-0.83) and phosphorus (B-0.25), adjusted for confounding variables (R2 0.34). CONCLUSION: Our results indicate that central obesity was significantly and inversely associated with Mg and phosphorus and directly with uric acid in indigenous school children. Supplementation with Mg and/or phosphorus could prevent future cardiovascular disease. Prospective and randomized studies should be performed to confirm these findings.

[Migration from a rural zone to an urban one is associated with android distribution of body fat in obese women]. / La migración de zona rural a urbana se asocia con la distribución androide de grasa corporal en mujeres obesas.

INTRODUCTION: Studies about migration to industrialized countries have shown an increased prevalence of diabetes, obesity and dyslipidaemias, all of them related to android body fat distribution. Migration status might be influence body fat distribution but it has not been sufficiently investigated. The aim of this study is to determine the relationship between body fat distribution and migration from rural to urban areas in Mexico. MATERIAL AND METHODS: This sequential sample of 433 women were seen in the outpatient obesity clinic of four federal states: Tabasco (n = 81), Mexico City (n = 166), Coahuila (n = 80), and Yucatan (n = 106). Migration history from rural to urban area, familial history of diabetes, ages of onset of obesity, height and weight circumferences were obtained. A regression logistic model was used and maintained as dependent variable body fat distribution. Age and federal state were considered as confounders and they adjusted the model. RESULTS: Migrating women from rural to urban area were 121 (27.9%). The waist circumference was higher in Tabasco (102.2 +/- 12 cm), and lesser in Yucatan (93.6 +/- 15 cm, p < 0.001); no differences were found for hip circumference. The logistic regression model showed that body fat distribution is associated to migration from rural to urban area, and also to diabetes of mother and age of onset of obesity. CONCLUSIONS: Migrating from rural to urban area is a risk factor for android body fat distribution and this risk increases with age, history of diabetes in mother and adulthood onset o obesity.

Antibody response to Mycobacterium tuberculosis antigens in children with pulmonary tuberculosis and in BCG vaccinated non tuberculous pediatric patients.

In this work we look for the antibody response to M. tuberculosis antigens in 38 children with pulmonary tuberculosis: 18 bacteriologically and 20 clinically diagnosed as compared to the response of 52 children with other respiratory illnesses in which tuberculosis was definitively ruled out. In this control group 24 had been BCG vaccinated and 28 had not. Antibodies were detected by ELISA and immunoblot using a crude extract of M. tuberculosis as antigen. All 38 tuberculous diagnosed children tested positive, by ELISA, to the bacterial extract as did previously vaccinated controls (18/24), while all 28 non vaccinated controls gave negative results (sensitivity = 1.0, specificity = 0.68). By Western blot, tuberculous patients recognized a 12 kDa protein that was not recognized by the control vaccinated group. This partially purified protein which was used in an ELISA resulted positive in all 18 bacteriologically, in 17/20 clinically diagnosed patients, and in only 6/24 vaccinated controls. Specificity increased to 0.86, with a sensitivity of 0.93.