Profiles of Posttraumatic Growth and Posttraumatic Stress Symptoms in Childhood Cancer Survivors.

The experience of childhood cancer (CC) could be a traumatic event that produces long-term emotional responses such as posttraumatic stress symptoms (PTSS) and posttraumatic growth (PTG) in survivors. The relationship between both PTSS and PTG is not clear in CC survivors. Assessing challenges to core beliefs and rumination could give information regarding the different paths that lead to traumatic responses. Thus, this study aims to identify childhood cancer survivors' profiles from PTSS and PTG measures and to examine the pathways of relationships between PTSS and PTG, rumination, and challenge to core belief. Sixty-two CC survivors completed surveys on their childhood cancer experience, PTSS, PTG, challenge to core beliefs, and rumination. High PTG scores among childhood cancer survivors (Cluster 1), High PTSS scores among childhood cancer survivors (Cluster 2), and Childhood cancer survivors without changes (Cluster 3). Network analysis found that the challenge to core beliefs is the central point in the relationship between the variables, in a direct and positive relationship with PTG. We found an indirect path from challenge to core beliefs to PTSS, mediated by intrusive and deliberative ruminations. The combined findings suggested that there are different profiles related to trauma in CC survivors and the relationship between PTSS and PTG is mediated by the challenge to core beliefs and deliberative and intrusive rumination.

Stress and Post-traumatic Growth of people with cancer: identification of associated factors / Estrés y Crescimiento Postraumático de personas con cáncer: identificación de factores asociados

Objectives: Evaluate indicators and identify associated factors of post-traumatic stress disorder (PTSD) and post-traumatic growth (PTG) in individuals undergoing oncological treatment. Method: Quantitative, cross-sectional, analytical survey design with a non-probabilistic sample of 74 participants. Six instruments measuring PTSD, PTG, spiritual well-being, illness perception, and social support were employed. Data were analyzed using descriptive and inferential statistics in the Statistical Package for Social Science (SPSS). Results: It was evidenced that 21.60% of patients presented clinical indices of PTSD, and 85.12% showed a high index for PTG. High satisfaction indices were also observed for social support (86.48%), spiritual well-being (95.94%), and in identifying cancer as a potential threat to life (71.57%). Females, unmarried individuals, those inactive or unemployed, and those receiving public health support exhibited higher PTG indices. Women exhibit higher PTSD indices than men. Negative correlations were found between PTSD and spiritual well-being, and positive correlations with illness perception. Illness perception emerged as the variable with the greatest predictive power for PTSD indices. Conclusions: It is concluded that the threatening perception of the illness is a predictor of PTSD, highlighting it as a risk factor that requires attention in health prevention plans.(AU)

Objetivos: Evaluar los indicadores e identificar los factores asociados al trastorno de estrés postraumático (TEPT) y al crecimiento postraumático (CPT) en personas sometidas a tratamiento oncológico. Método: Diseño cuantitativo, transversal, analítico y de encuesta, con una muestra no probabilística compuesta por 74 participantes, utilizando seis instrumentos que miden TEPT, CPT, bienestar espiritual, percepción de la enfermedad y apoyo social, analizados a través de estadísticas descriptivas e inferenciales, en el Programa Estadístico para Ciencias Sociales (SPSS). Resultado: Se evidenció que 21,60% de los pacientes presentaron índices clínicos de TEPT y 85,12% un índice elevado para CPT. También se observaron índices elevados de satisfacción con el apoyo social (86,48%), bienestar espiritual (95,94%) e identificación del cáncer como una posible amenaza a la vida (71,57%). Las personas del género femenino, solteras, inactivas o desempleadas y atendidas por el servicio público de salud presentan mayores índices de CPT. Las mujeres muestran mayores índices de TEPT que los hombres. Se encontraron correlaciones negativas entre TEPT y bienestar espiritual y correlaciones positivas con la percepción de la enfermedad. La percepción de la enfermedad fue la variable con mayor poder predictivo para los índices de TEPT. Conclusiones: Se concluye que la percepción amenazante de la enfermedad es un predictor de TEPT, siendo esta una variable de riesgo que requiere atención en los planes de prevención de daños a la salud.(AU)

Environmental Management of Equine Asthma.

Environmental practices related to the inhalation of airborne dust have been identified as the main cause of equine asthma (EA) and reasonably, they are truly relevant in its treatment and control, especially for horses with its severe form. Vast research regarding environmental recommendations has been conducted in recent years. However, no recent exhaustive reviews exist that gather all this new evidence. The aim of this review is to report and compare the most pertinent information concerning the environmental management of EA. The main findings highlight the importance of the type of forage used for feeding but also its method of production and possible contamination during manufacture and/or storage. Procedures to reduce this, such as soaking and steaming hay, improve its hygienic quality, although they also decrease forage's nutritional value, making dietetic supplementation necessary. Regarding stabling, despite some conflicting results, avoiding straw as bedding and improving barn ventilation continue to be the common recommendations if turning to pasture is not feasible. Finally, owners' compliance has been identified as the most critical point in correct environmental control. Educating owners about the genuine benefits of these measures should be a cornerstone of EA management.

Cross-Cultural Adaptation and Validation of the ICIQ-BD for Brazilian Women With Lower Urinary Tract Symptoms.

INTRODUCTION AND HYPOTHESES: The International Continence Society recommends the International Consultation on Incontinence Questionnaire-Bladder Diary (ICIQ-BD) for the assessment, management, and monitoring of lower urinary tract symptoms (LUTS). Translation, cross-cultural adaptation and validation will establish a valid and reliable tool for Brazilian women with LUTS. METHODS: A cross-sectional study involving 101 women was carried out at the Urogynecology Outpatient Clinic in Belo Horizonte, Brazil, between August 2020 and April 2022. The process of cross-cultural adaptation and validation was executed following the ICIQ Group's protocol. Reviewed by an expert committee, the first pre-test was followed by subsequent adaptations, resulting in a second adapted version that underwent expert revisions. A second pretest was conducted, followed by cross-cultural adaptation and construct validation. Finally, the International Consultation on Incontinence Questionnaire-Bladder Diary-Brazilian Portuguese Version (ICIQ-BD-Br) underwent a validation process. RESULTS: Construct validity (IVC >0.78) and internal consistency were satisfactory (α-Cronbach coefficient 0.87-0.94). The following adjustments were made: a specific field was created to document sleep and wake times, and a printed score ranging from 0 to 4 was included in the bladder sensation column. Test-retest reliability ranged from fair to excellent for all analyzed items (Spearman correlation: 0.64-0.95). Criterion validity analysis indicated slight agreement for one of the four symptoms analyzed (nocturia k=0.32). The final version was approved by the ICIQ Group. CONCLUSIONS: The ICIQ-BD-Br has been adapted for use in Brazilian Portuguese and has exhibited robust construct validity and reliability for Brazilian women with LUTS.

Comunicação Emocional em Saúde: Apresentando a Ferramenta de Codificação de Verona de Sequências Emocionais (VR-CoDES) / Emotional Communication In Healthcare: A Tool for Verona Coding Definitions to Emotional Sequences (VR-Codes)

A comunicação clínica, com foco nas competências emocionais, é uma habilidade que requer treinamento devido à necessidade de reconhecer expressões emocionais dos pacientes e dar uma resposta adequada. O objetivo deste estudo é apresentar uma ferramenta para avaliação da comunicação emocional dos profissionais de saúde, abordando as principais definições teóri-cas sobre a temática e pesquisas baseadas em evidências que aplicaram a ferramenta Codifica-ção de Verona para Sequências Emocionais(VR-CoDES). Baseado numa pesquisa de levantamen-to bibliográfico, o estudo analisa a comunicação emocional dos profissionais de saúde e o uso dessa ferramenta, tendo em vista que a comunicação é a componente chave na alta qualidade do tratamento, com impacto na satisfação e adesão dos pacientes. O estudo discute a impor-tância do reconhecimento de pistas e preocupações emocionais de pacientes em tratamentos de saúde e destaca as lacunas e desafios sobre os treinamentos de habilidades de comunicação emocional nos contextos de saúde. (AU)

Emotional communication in health is a tool to improve communication skills regarding the need to recognize patients’ emotional expressions and give them an adequate response. This study aims to show a tool to assess the emotional communication of health professionals, ad-dressing the main theoretical definitions and evidence-based research that applied the Verona Coding Definitions of Emotional Sequences (VR-CoDES) methodology. Based on bibliographic research, the study analyzes the use of the VR-CoDES on emotional communication of health professionals, considering that communication is the key component in the high quality of treatment, with an impact on patient satisfaction and compliance. The study discusses the importance of recognizing patients’ emotional cues and concerns in health care and highlights the gaps and challenges in training emotional communication skills in health contexts. (AU)

Analysis on a database of ship accidents in port areas.

In the last 15 years, the number of vessels in the world fleet has grown by around 53% and their gross tonnage has increased by 47%, with a consequent significant increment of marine accidents worldwide. Accident database are the basic resource for risk assessment methods to help decision-makers to enact strategies and undergo hazard and vulnerability mitigation measures. Understanding ship accidents distribution in terms of involved GT, typical age of the affected vessels, category of the ships, as well as distribution of underlying causes and consequences is the first necessary step to improve accident mitigation actions to be implemented for future assessments. In the present work, the results of an analysis on a database of vessel accidents in Mediterranean and worldwide port areas developed within the framework of the project ISY PORT (Integrated SYstem for navigation risk mitigation in PORTs) is herein presented. The distribution of accidents was analyzed in terms of relevant vessel characteristics i.e. Grosse Tonnage (GT), age at the time of the accident, ship's category, causality event, weather conditions and number of fatalities/injuries/lost at sea. The database can be used as a basis for maritime risk assessment methods and for calibration of real-time ship collision avoidance scenarios.

How physicians respond to the emotional expressions of people with cancer / Cómo responden los médicos a las expresiones emocionales de las personas con cancer

The aim of this study is to examine patient emotional cues to oncologists’ responses and explore the association between the concerns and emotional cues during the consultation and the physicians’ response to them throughout treatment, satisfaction, and the assessment of the patients’ perception of the established communication. Method: Cross-sectional design, involved 12 adults patients undergoing cancer treatment and eight physicians in the study. The twelve video-recorded medical consultations were coded (349 cues/concern) using the Verona coding definitions of emotional sequences (VR-CoDES). Results: A strong association between explicit with reducing space responses and the physiological symptoms cues (x²=6.029; p=0.014), and related to the repetition cue of the content by the patient (x²=5.599; p=0.018) was observed. Patients expressed fewer non-verbal behaviors (for example, crying, silence, silent pauses), as they had been undergoing treatment for a longer time, therefore, provided with more empathic responses from physicians. Conclusion: The identification of emotions can help physicians to further explore patients’ underlying cues that reveal emotional distress concerning illness and treatment in a less explicit way. There is a need for improvement in the physician’s ability to recognize patients’ concerns and to provide space for patients to have comprehensive health care, considering the severity of cancer disease and its negative emotional impacts for patients (AU)

El objetivo de este estudio es examinar cómo los oncólogos responden a las preocupaciones emocionales de las personas con cáncer durante el tratamiento, relacionarlas con la satisfacción y evaluar las percepciones de comunicación de los pacientes. Diseño transversal, en el que participaron 12 pacientes adultos en tratamiento oncológico y ocho médicos en el estudio. Las doce consultas médicas grabadas en vídeo se codificaron (349 pistas/inquietudes) utilizando las definiciones de codificación de secuencias emocionales de Verona (VR-CoDES). Hubo fuerte asociación entre respuestas explícitas con reducción de espacio y claves de síntomas fisiológicos (x²=6,029; p=0,014), y relacionada con la repetición de claves de contenido por parte del paciente (x²=5,599; p=0,018). Los pacientes expresaron menos comportamientos no verbales (por ejemplo, llanto, silencio, pausas silenciosas) ya que habían estado en tratamiento por más tiempo y, por lo tanto, tenían respuestas más empáticas por parte de los médicos. La identificación de las emociones puede ayudar a los médicos a explorar más a fondo las pistas subyacentes de los pacientes que revelan angustia emocional por la enfermedad y el tratamiento de una manera menos abierta. Existe la necesidad de mejorar la capacidad del médico para reconocer las preocupaciones de los pacientes y hacer espacio para que los pacientes tengan una atención integral en salud, considerando la gravedad de la enfermedad oncológica y sus impactos emocionales negativos para los pacientes (AU)

Pharmacokinetics and oral bioavailability of cannabidiol in horses after intravenous and oral administration with oil and micellar formulations.

BACKGROUND: Intravenous pharmacokinetics and oral bioavailability of cannabidiol (CBD) with different formulations have not been investigated in horses and may represent a starting point for clinical studies. OBJECTIVES: To describe pharmacokinetics after intravenous and oral administrations with oil and micellar formulations and simulate different treatments. STUDY DESIGN: Single intravenous experiment and two-way randomised oral experiments, Latin-square design. METHODS: Eight healthy horses received intravenous CBD at 1.00 mg/kg dose, oral CBD in sesame oil and in micellar formulation, both at 10.00 mg/kg. Concentrations were measured using LC-MS/MS and fitted by nonlinear mixed effect modelling. Parameters obtained were used to simulate single and multiple treatments at steady state. RESULTS: Intravenous and oral concentrations were simultaneously fitted using a three-compartment model. Final estimates indicate that CBD has a volume of distribution of 36 L/kg associated with a systemic clearance of 1.46 L/h/kg and half-lives ranged between 24 and 34 h. Oral bioavailability was close to 14% for both oral administrations. Simulated dose regimen of CBD every 12 and 24 h predicted similar percentages to reach effective plasma concentration with both oral formulation at 10.00 mg/kg. MAIN LIMITATIONS: A small horse population was used (8 horses per trial). CONCLUSIONS AND CLINICAL IMPORTANCE: Oral bioavailability was low at the doses studied but fell within the range described for horse and other species. CBD had a high steady-state volume of distribution, a high clearance and long half-lives. No adverse reactions were detected at any dose or route. The micellar formulation showed a faster absorption and higher concentration peak, while the oil formulation presented lower levels, but more maintained over time. Simulations predicted that both could be useful in multiple oral dose treatments. These results indicated that CBD could be of interest, but further studies are needed to evaluate its clinical use in horses.

Posttraumatic growth among childhood cancer survivors and their care-givers: associations with rumination and beliefs challenge / Crecimiento postraumático entre sobrevivientes de cáncer infantil y sus cuidadores: asociaciones con rumiación y desafío de creencias

Abstract. The main purpose of the study was to assess the relationship between PTG, challenge to core beliefs, intrusive and deliberate rumination in a sample of 43 dyads of childhood cancer survivors and their caregivers. Methods: Survivors (mean age = 17.04; SD=3.67) and caregivers (mean age = 46.84; SD = 8.32) completed the Posttraumatic Growth Inventory (PTGI), the Core Beliefs Inventory (CBI) and the Event-related Rumination Inventory (ERRI). Results: Results showed a positive and high correlation among PTG, CBI, and ERRI in both groups, separately. CBI was the main predictor of PTG both among survivors (β=0.826; t=9.393; R²=0.683; p≤0.001) and caregivers (β=0.552; t=4.235; R²=0.304; p≤0.001). Caregivers reported higher scores than survivors in PTG (t=-2.999 p≤0.01) and its dimensions Relationship with others (t=2.498; p≤0.05), Spiritual change (t=-15.823; p≤0.001), Life appreciation (t=-3.129;

Resumen. El objetivo principal del estudio fue evaluar la relación entre el CPT, el desafío a las creencias, la rumiación intrusiva y deliberada en una muestra de 43 díadas de sobrevivientes de cáncer infantil y sus cuidadores. Métodos: Los sobrevivientes (edad media = 17,04; SD = 3,67) y los cuidadores (edad media = 46,84; SD = 8,32) completaron el Inventario de Crecimiento Postraumático (PTGI), el Inventario de Creencias Básicas (CBI) y el Inventario de Rumiación Relacionada con Eventos (ERRI). Resultados: Los resultados mostraron una correlación positiva y alta entre PTG, CBI y ERRI en ambos grupos, por separado. El CBI fue el principal predictor de CPT tanto entre los sobrevivientes (β=0,826; t=9,393; R²=0,683; p≤0,001) como entre los cuidadores (β=0,552; t=4,235; R²=0,304; p≤0,001). Los cuidadores reportaron puntajes más altos que los sobrevivientes en CPT (t=-2,999 p≤0,01) y sus dimensiones Relación con los demás (t=2,498; p≤0,05), Cambio espiritual (t=-15,823; p≤0,001), Valoración de la vida (t =-3,129;

Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.

Inoculants with beneficial microorganisms comprise both selected strains and carriers that ensure a favorable microenvironment for cell survival and stability. Formulations of inoculants using synthetic polymers as carriers are common. However, only a few studies are available in the literature regarding the formulation of inoculants using natural biomolecules as carriers. Exopolysaccharides (EPS) are biomolecules produced by a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia. EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses. Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium. Their EPS were characterized through a series of analytical techniques, aiming at their use in the formulation of plant inoculants. In addition, the effect of the carbon source on EPS yield was evaluated. Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy. Thermal stability (thermogravimetric) was close to 270 °C and viscosity ranged from 120 to 1053.3 mPa.s. Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity. The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.

Inhibitory effect of Mexican oregano (Lippia graveolens Kunth) extracts on digestive enzymes in vitro, and beneficial impact on carbohydrates and lipids absorption in vivo.

ETHNOPHARMACOLOGICAL RELEVANCE: Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed. AIM OF THE STUDY: Assess the effect of Mexican oregano (Lippia graveolens Kunth) on carbohydrates and lipids absorption in vivo. The antioxidant activity also was investigated. MATERIALS AND METHODS: Enzymatic inhibitory action of lipase, α-amylase, and α-glucosidase was evaluated in vitro. Oral lipid (OLTT) and starch tolerance tests (OSTT) were conducted with L. graveolens acetone (O-A) and ethanol (O-E) extracts (at 102 mg/kg body weight equivalent to a 1 g human doses) in male Wistar rats. The antioxidant activity was evaluated through inhibition of lipid peroxidation and scavenging radical. RESULTS: Both extracts exhibited higher inhibitory median concentration (IC50) of lipase activity (1.9 µg/µL for O-E and 1.8 µg/µL for O-A) than the positive control (Orlistat) (0.07 µg/µL). The IC50 of α-amylase was higher (41.8 µg/µL for O-E and 25.2 µg/µL for O-A) than the Acarbose (2.5 µg/µL); while α-glucosidase results showed not statistically differences between groups (∼1.7 µg/µL). The OLTT results showed that both extracts significantly reduced serum triglycerides (∼147 mg/dL for O-E and ∼155 mg/dL for O-A) as compared with negative control group (only lipid load). In the OSTT, glucose levels showed a significant decrease (∼31 mg/dL for O-E and ∼17 mg/dL for O-A) than the negative control group (only starch load). About in vitro antioxidant evaluation, not statistically differences between extracts and positive control (Trolox) were observed for scavenged free radicals (∼2.0 µg/µL); whereas O-A inhibited lipid peroxidation similar to the Trolox (∼0.8 µg/µL IC50). The main chemical composition of both extracts was coumaric acid, luteolin, rutinoside, naringenin, and carvacrol. CONCLUSIONS: Both extracts reduce lipid absorption; whereas O-E decreases carbohydrate absorption in vivo. Both extracts inhibit lipid peroxidation and scavenging free radicals in vitro.

Illness perceptions in childhood cancer survivor and caregivers' dyads.

Surviving childhood cancer is a difficult experience for children and their caregivers, it can produce long-term emotional distress. Illness perceptions refer to the way people understand the different aspects related to illness from their individual and collective experiences. OBJECTIVE: to compare the illness perceptions of adolescent childhood cancer survivors and their caregivers and examine the relationship between illness perception of childhood cancer survivors, their caregivers, and sociodemographic, illness, and treatment variables. Forty-three survivor-caregiver dyads (the mean age of a survivor 17.05 years old; the mean age of caregivers 47.53 years old) participated in the study and answered the Brief Illness Perception Questionnaire (Brief IPQ) and Demographics data. RESULTS: Results showed significant differences in the illness perceptions of survivors and caregivers. Caregivers presented more negative cognitive perceptions than survivors (t = -6.701, p < 0.001), especially in the identity dimension (t = -4.327, p < 0.001), and more negative emotional perceptions than survivors (t = -4.132, p < 0.001), both in concern (t = -3.695, p < 0.001) and emotional representation (t = -3.466, p < 0.001). No significant correlations were found between survivors' and caregivers' illness perceptions and sociodemographic illness variables. CONCLUSION: These findings showed that even though dyads went through cancer together, survivors' and caregivers' perceptions of childhood cancer are different, indicating the need to better understand how children growing up with a chronic disease develop such illness perceptions and their experience.

Debaryomyces hansenii Is a Real Tool to Improve a Diversity of Characteristics in Sausages and Dry-Meat Products.

Debaryomyces hansenii yeast represents a promising target for basic and applied biotechnological research It is known that D. hansenii is abundant in sausages and dry-meat products, but information regarding its contribution to their characteristics is blurry and contradictory. The main goal in this review was to define the biological contribution of D. hansenii to the final features of these products. Depending on multiple factors, D. hansenii may affect diverse physicochemical characteristics of meat products. However, there is general agreement about the significant generation of volatile and aromatic compounds caused by the metabolic activities of this yeast, which consequently provide a tendency for improved consumer acceptance. We also summarize current evidence highlighting that it is not possible to predict what the results would be after the inoculation of a meat product with a selected D. hansenii strain without a pivotal previous study. The use of D. hansenii as a biocontrol agent and to manufacture new meat products by decreasing preservatives are examples of exploring research lines that will complement current knowledge and contribute to prepare new and more ecological products.

The Potassium Transporter Hak1 in Candida Albicans, Regulation and Physiological Effects at Limiting Potassium and under Acidic Conditions.

The three families of yeast plasma membrane potassium influx transporters are represented in Candida albicans: Trk, Acu, and Hak proteins. Hak transporters work as K+-H+ symporters, and the genes coding for Hak proteins are transcriptionally activated under potassium limitation. This work shows that C. albicans mutant cells lacking CaHAK1 display a severe growth impairment at limiting potassium concentrations under acidic conditions. This is the consequence of a defective capacity to transport K+, as indicated by potassium absorption experiments and by the kinetics parameters of Rb+ (K+) transport. Moreover, hak1- cells are more sensitive to the toxic cation lithium. All these phenotypes became much less robust or even disappeared at alkaline growth conditions. Finally, transcriptional studies demonstrate that the hak1- mutant, in comparison with HAK1+ cells, activates the expression of the K+/Na+ ATPase coded by CaACU1 in the presence of Na+ or in the absence of K+.

Estrutura interna da versão brasileira do Questionário de Estresse Traumático Secundário / Internal structure of the Secondary Traumatic Stress Questionnaire in Brazil / Estructura interna de la versión brasileña del Cuestionario de Estrés Traumático Secundario

O Estresse Traumático Secundário caracteriza-se por um conjunto de sintomas e condutas que se manifestam após a exposição indireta ao trauma. Profissionais que cuidam de pessoas traumatizadas estão susceptíveis ao transtorno. Este estudo examinou a estrutura interna da versão brasileira do Cuestionario de Estrés Traumático Secundario. Participaram 624 profissionais da saúde, acessados on-line. Para realização das análises fatoriais, a amostra foi dividida em dois grupos. Na análise exploratória, foram retidos 12 componentes, com cargas fatoriais entre 0,312 e 0,999. Os resultados da análise confirmatória revelaram que o modelo de doze fatores para 50 itens forneceu o melhor ajuste possível para os dados (RMSEA = 0,044; IC = 10%-90%; CFI = 0,949; TLI = 0,904) e índice de consistência interna geral do modelo foi de 0,91. Esses doze fatores foram distribuídos em quatro escalas (Antecedentes, Síndrome de Trauma Secundário, Personalidade e Consequências), com índices psicométricos relativamente baixos e uma nova organização dos itens das escalas do QETS, em contraste com a versão teórica original do instrumento. Sugere-se que novos estudos psicométricos analisem as escalas do questionário, separadamente, e investiguem outras categorias profissionais, especialmente na área dos serviços de emergências, além de estudos comparativos com amostras clínicas. (AU)

Secondary Traumatic Stress is characterized by a set of symptoms and behaviors that manifest themselves after the indirect exposure to the trauma. Professionals caring for traumatized people are susceptible to the disorder. This study examined the internal structure of the Brazilian version of the Cuestionario de Estrés Traumático Secundario. 624 health professionals participated, accessing the online questionnaire. To perform the factorial analysis, the sample was divided into two groups. In the exploratory analysis, 12 components were retained, with factorial loads between 0.312 and 0.999. The confirmatory analysis revealed a twelve-factor model for 50 items provided the best possible fit for the data (RMSEA = 0.044; CI = 10% -90%; CFI = 0.949; TLI = 0.904). However, at the end of the data discussion, 48 items remained in the model, and the overall internal consistency index of the model was 0.91. These twelve factors were distributed on four scales (Background, Secondary Trauma Syndrome, Personality and Consequences), with relatively low psychometric indices and a new organization of the items on the QETS scales in contrast to the theoretical framework in the the original instrument. It is suggested that new psychometric studies analyze the scales of the questionnaire separately and investigate other professional categories, especially in the area of emergency services and comparative studies with clinical samples. (AU)

El estrés traumático secundario se caracteriza por un conjunto de síntomas y conductas que se manifiestan después de la exposición indirecta al trauma. Los profesionales que cuidan a las personas traumatizadas son susceptibles al trastorno. Este estudio examinó estructura interna de la versión brasileña del Cuestionario de Estrés Traumático Secundario. Participaron 624 profesionales de la salud, accediendo al cuestionario online. Para la realización de los análisis factoriales la muestra fue dividida en dos grupos. En el análisis exploratorio, se retuvieron 12 componentes, con cargas factoriales entre 0.312 y 0.999. El análisis confirmatorio reveló que el modelo de doce factores para 50 ítems proporcionó el mejor ajuste posible para los datos (RMSEA = 0.044; IC = 10% -90%; CFI = 0.949; TLI = 0.904). Sin embargo, al final de la discusión de los datos quedaron 48 ítems en el modelo. El índice de consistencia interna general del modelo fue de 0,91. Estos doce factores se distribuyeron en cuatro escalas (Antecedentes, Síndrome de Trauma Secundario, Personalidad y Consecuencias), con índices psicométricos relativamente bajos y una nueva organización de los ítems en las escalas QETS, en contraste con la versión teórica original del instrumento. Se sugiere que nuevos estudios psicométricos analizan las escalas del cuestionario por separado e investiguen otras categorías profesionales, especialmente en el área de los servicios de emergencias y estudos comparativos con amostras clínicas. (AU)

Relationship between doctors and patients in the end of life process in palliative care and dysthanasia / Relación entre médicos y pacientes en proceso en el final de la vida en cuidados paliativos y distanasia

Introduction: In the course of an illness, when the patient receives a poor prognosis, he can be assisted with dysthanasia or palliative care. The therapeutic choice and the adherence to it are related, among other factors, to the quality of the doctor-patient relationship. The objective of this study was to evaluate the patients’ point of view of the doctor-patient relationship in the end of life process, and compare scores between patients in palliative care and those experiencing dysthanasia.Method: The design was a descriptive survey with a non-probabilistic sample composed of 234 patients with cancer in the end of life process: 117 in palliative care and 117 expriencing dysthanasia. Two instruments were used: a biodemographic questionnaire and the Questionnaire for Assessing the Doctor-Patient Relationship in the End of Life Process, and data were analyzed using descriptive and bivariate statistics in the Statistical Package for the Social Sciences software. Results: The results showed good evaluations of the doctor-patient relationship. Palliative care patients attributed better scores in terms of time dedicated, attention, confidence, understanding and communication; and patients experiencing dysthanasia made better assessments in terms of frequency of visits and continuity of care. Conclusion: It is concluded that this study represents an advance in studies on the subject and indicates that patients in palliative care perceive the doctor-patient relationship more positively than patients undergoing dysthanasia. It stressed that it is necessary to invest in training medical students and professionals to carry out interventions that prioritize the use of their oldest, simplest and most powerful technology: the relationship between professionals and patients (AU)

Objetivo: En el curso de una enfermedad, cuando el paciente recibe un pronóstico reservado, puede ser asistido con distanasia o con cuidados paliativos. La elección terapéutica y la adherencia están relacionadas, entre otros factores, con la calidad de la relación médico-paciente. El objetivo fue evaluar, desde el punto de vista de los pacientes, la relación médico-paciente en el proceso de finitud, y comparar sus índices entre pacientes en cuidados paliativos y en distanasia.Método: El diseño es descriptivo y encuesta, y tuvo una muestra no probabilística compuesta por 234 pacientes con cáncer en proceso de finitud: 117 en cuidados paliativos y 117 en distanasia. Se utilizaron dos instrumentos, un cuestionario biodemográfico y un cuestionario para la evaluación de la relación médico-paciente, cuyos datos fueron analizados mediante estadística descriptiva y bivariada en el software Statistical Package for the Social Sciences. Resultados: Los resultados mostraron que los pacientes tuvieron buenas evaluaciones de la relación médico-paciente. Los pacientes de cuidados paliativos tuvieron mejores índices en términos de tiempo dedicado, atención, confianza, comprensión y comunicación; y los pacientes en distanasia evaluaron mejor la frecuencia de las visitas y la continuidad de la atención. Conclusión: Se concluye que el estudio representa un avance en los estudios sobre el tema e indica que los pacientes en cuidados paliativos perciben la relación médico-paciente de manera más positiva que los pacientes en distanasia. Se refuerza la necesidad de invertir en la formación de estudiantes y profesionales de medicina para llevar a cabo intervenciones que prioricen el uso de su tecnología más antigua, sencilla y poderosa: la relación entre profesionales y pacientes (AU)

Percepção de risco e comportamentos de saúde em relação ao sexo casual em universitárias / Risk perception and health behaviors in relation to casual sex in college women / Percepción de riesgo y conductas de salud en relación al sexo casual en estudiantes universitárias

Este estudo buscou explorar e comparar a percepção dos riscos à saúde física e os comportamentos de saúde do sexo casual entre universitárias com (CEX) e sem experiência (SEX) de sexo casual. Participaram 1.133 universitárias brasileiras (média de idade igual a 21,05 anos, DP = 2,05), a maioria nascidas e residentes na região Sul do país, que responderam a um questionário on-line com questões sobre a percepção dos riscos físicos, comportamentos de saúde, comportamento e histórico sexual. Foi encontrada diferença significativa nos comportamentos de saúde e nas percepções de risco entre os grupos. O grupo CEX apresentou mais comportamentos de saúde e cuidados que o grupo SEX. Embora o sexo casual esteja relacionado aos comportamentos de risco, neste estudo, as mulheres CEX apresentaram mais medidas de proteção à saúde que as mulheres SEX. (AU)

This study aimed to explore and compare the perceptions of physical health risks and healthy sex behaviors among female university students with (CEX) and without (SEX) experience in casual sex. With a comparative cross-sectional design, the study included 1,133 Brazilian female university students (mean age 21.05 years, SD=2.05), mostly born and resident in the southern region of the country, who completed an online questionnaire about their perception of physical risks, their health behaviors, and their sexual behavior and history. There was a significant difference in health behaviors and risk perceptions between the two groups, where the CEX group showed higher levels of healthy behaviors and care than the SEX group. Although casual sex is related to risk behaviors, in this study, women in the CEX group reported taking more health protection measures than those in the SEX group. (AU)

La investigación tuvo como objetivo explorar y comparar la percepción de riesgo con la salud física y las conductas de salud relacionadas al sexo casual entre estudiantes universitarias con (CEX) y sin experiencia (SEX) de sexo casual. Participaron 1.133 estudiantes universitarias brasileñas (edad media de 21,05 años, DS=2,054), mayoritariamente nacidas y residentes de la región sur del país, que contestaron a un cuestionario online con preguntas sobre percepción de riesgos físicos, sus conductas de salud e historial sexual. Se pudo observar una diferencia significativa en los comportamientos de salud y en las percepciones de riesgo entre los grupos. El grupo CEX presentó más conductas saludables y de cuidados que el grupo SEX. Aunque el sexo casual esté relacionado con conductas de riesgo, en este estudio las mujeres CEX presentaron más medidas de protección a la salud que las mujeres del grupo SEX. (AU)

Physicians privilege responding to emotional cues in oncologic consultations: A study utilizing Verona Coding Definitions of Emotional Sequences.

The aim of this study was to describe emotional cues and concerns expressed by cancer patients and their physicians using video-recorded regular oncology consultations. The consultations were divided into units of analysis and coded according to the Verona Coding Definitions of Emotional Sequences system. The study design was mixed, descriptive, and exploratory. Twelve patients and eight oncologists participated in the study. The patients expressed 349 cues/concerns during the 12 consultations. The majority (68.8%) of the content consisted of non-explicit description of physiological and stress episodes in the disease and treatment. Physicians demonstrated that they recognized fewer underlying cues than those related to physiological complaints.

Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders.

Obesity and its associated complications, such as metabolic syndrome, are an increasing problem in both humans and horses in the developed world. The expression patterns of resistin differ considerably between species. In rodents, resistin is expressed by adipocytes and is related to obesity and ID. In humans, resistin is predominantly produced by inflammatory cells, and resistin concentrations do not reflect the degree of obesity, although they may predict cardiovascular outcomes. The aim of this study was to investigate the usefulness of resistin and its relationship with ID and selected indicators of inflammation in horses. Seventy-two horses, included in one of the four following groups, were studied: healthy controls (C, n = 14), horses with inflammatory conditions (I, n = 21), horses with mild ID (ID1, n = 18), and horses with severe ID (ID2, n = 19). Plasma resistin concentrations were significantly different between groups and the higher values were recorded in the I and ID2 groups (C: 2.38 ± 1.69 ng/mL; I: 6.85 ± 8.38 ng/mL; ID1: 2.41 ± 2.70 ng/mL; ID2: 4.49 ± 3.08 ng/mL). Plasma resistin was not correlated with basal insulin concentrations. A significant (r = 0.336, p = 0.002) correlation was found between resistin and serum amyloid A. Our results show that, as is the case in humans, plasma resistin concentrations in horses are predominantly related to inflammatory conditions and not to ID. Horses with severe ID showed an elevation in resistin that may be secondary to the inflammatory status associated with metabolic syndrome.

Assessing the Relationship between PTSS in Childhood Cancer Survivors and Their Caregivers and Their Quality of Life.

Childhood cancer is a traumatic experience for survivors and their families. The experience of this disease affects survivors' and families' quality of life, even years after it occurs. The purpose of the present study was to assess if the caregivers' posttraumatic stress symptoms mediated the associations between survivors' posttraumatic stress symptoms and caregivers' quality of life, in a sample of 46 dyads of caregivers and childhood cancer survivors. Survivors and caregivers completed the PCL-5, and caregivers completed the WHOQOL-bref. Results showed that survivors' and caregivers' posttraumatic stress symptoms scores and caregivers' quality of life were associated. The caregivers' posttraumatic stress symptoms mediated the relationship between survivors' posttraumatic stress symptoms and caregivers' quality of life. Knowing posttraumatic stress symptoms direct and indirect effects on caregivers' quality of life contributes to understand their experience and to develop intervention strategies with this population.