Asunto(s)
Eritema Necrolítico Migratorio , Tumores Neuroendocrinos , Neoplasias Pancreáticas , Humanos , Eritema Necrolítico Migratorio/etiología , Eritema Necrolítico Migratorio/patología , Tumores Neuroendocrinos/complicaciones , Tumores Neuroendocrinos/diagnóstico , Neoplasias Pancreáticas/complicaciones , Neoplasias Pancreáticas/patología , NecrosisRESUMEN
Inflammatory fibroid polyps (IFPs) are rare mesenchymal neoplasms affecting the gastrointestinal tract which are considered benign and noninvasive. We present a case of an invasive IFP in a 46-year-old woman who presented with signs of intestinal obstruction due to ileal intussusception. A segment of the small intestine was resected and subsequently intestinal continuity was restored. A polypoid lesion was found obstructing the lumen. Histopathology revealed a mesenchymal proliferation of spindle and stellate cells, without cytological atypia, arranged in a fibromyxoid stroma. The tumor cells were located in the submucosa but also infiltrated the muscularis propria and the subserosa and were CD34 positive. The molecular study by PCR showed mutation in exon 12 of the PDGFRA gene. IFP is considered a true neoplasm and can also be considered as a potentially invasive lesion
Los pólipos fibroides inflamatorios (PFIs) son considerados como neoplasias mesenquimales inusuales que afectan al tracto gastrointestinal. Son consideradas benignas y generalmente no invasivas. Presentamos un caso de PFI invasivo en una mujer de 46 años que evidenció signos de obstrucción intestinal por invaginación ileal. Se realizó resección de un segmento de intestino delgado y posterior desinvaginación manual del segmento resecado, observándose una lesión polipoide que obstruía la luz. Histológicamente, la lesión estaba constituida por una proliferación mesenquimal de células fusiformes y estrelladas sin atipia citológica, dispuestas en un estroma fibromixoide. Se encontraba localizada en la submucosa, aunque también infiltraba la capa muscular propia y la subserosa. Las células de la lesión fueron positivas para CD34. El estudio molecular mediante PCR demostró mutación en el exón 12 del gen PDGFRA. Actualmente el PFI es considerada una verdadera neoplasia que excepcionalmente tiene carácter invasivo
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Pólipos Intestinales/complicaciones , Intususcepción/etiología , Enfermedades del Íleon/etiología , Leiomioma/patología , Pólipos Intestinales/diagnóstico , Pólipos Intestinales/patología , Intususcepción/diagnóstico , Dolor Abdominal/etiología , Obstrucción Intestinal/diagnóstico por imagen , Pólipos Intestinales/cirugía , Diagnóstico Diferencial , Inflamación/patología , Leiomioma/cirugíaRESUMEN
Inflammatory fibroid polyps (IFPs) are rare mesenchymal neoplasms affecting the gastrointestinal tract which are considered benign and noninvasive. We present a case of an invasive IFP in a 46-year-old woman who presented with signs of intestinal obstruction due to ileal intussusception. A segment of the small intestine was resected and subsequently intestinal continuity was restored. A polypoid lesion was found obstructing the lumen. Histopathology revealed a mesenchymal proliferation of spindle and stellate cells, without cytological atypia, arranged in a fibromyxoid stroma. The tumor cells were located in the submucosa but also infiltrated the muscularis propria and the subserosa and were CD34 positive. The molecular study by PCR showed mutation in exon 12 of the PDGFRA gene. IFP is considered a true neoplasm and can also be considered as a potentially invasive lesion.
