Dependence of corneal hysteresis on non-central corneal thickness in healthy subjects.

OBJECTIVE: To evaluate the dependence of corneal hysteresis (CH) on non-central corneal thickness. METHODS: Cross-sectional study of 1561 eyes of 1561 healthy volunteers with IOP less than 21mmHg, open angles on gonioscopy and no prior eye surgeries or local or systemic diseases. Pentacam-Scheimpflug technology was employed to segment the cornea into 6 circular zones centered on the apex (zones 1-6) and to determine the mean corneal thickness of these areas. CH was measured with ORA. Univariate and multivariate linear regression models adjusted for age and sex were created to model the dependence of CH on corneal thickness in zones 1 to 6. RESULTS: In the univariate linear regression models, we found that CH was dependent on mean corneal thickness of zone 1 (B=0,004; R2=0.95%; P<0.001), zone 2 (B=0,004; R2=0.57%; P=0.002), zone 4 (B=0,005; R2=1.50%; P<0.001) and zone 6 (B=0,003; R2=0.92%; P<0.001). Similar results were obtained in the multivariate model (R2=3.46%; P<0.001). CONCLUSION: This study suggests a significant dependence of CH on non-central corneal thickness. The model of corneal thickness segmentation into circular zones centered on the corneal apex is able to explain 3.47% of the variation in CH measurements.

Síndrome de Charles Bonnet secundario a crisis hipertensiva / Charles Bonnet syndrome secondary to hypertensive crisis

No disponible

Oftalmología, historia y humanidades / Ophthalmology, history and humanities

No disponible

[Photodynamic therapy in severe chronic central serous chorioretinopaty]. / Terapia fotodinámica en coriorretinopatía serosa central crónica severa.

OBJECTIVE: To determine the efficacy of Photodynamic Therapy (PDT) in chronic Central Serous Chorioretinopathy (CSC). METHODS: Patients diagnosed with chronic CSC, with clinical evidence of activity and treated with Photodynamic Therapy, are included in this report. All were assessed by a complete ophthalmological examination, including assessment of the best corrected visual acuity (BCVA) using an ETDRS chart, fluorescein and indocyanine angiography and optical coherence tomography (OCT). The main objective of the study was to determine the mean visual acuity change. RESULTS: 11 eyes of 11 patients were included in the study, which had a mean follow-up period of 11 months. The mean BCVA increased from 20/76 to 20/64. 35% of eyes improved their BCVA by 2 lines or more, 45% remained stable and 18% lost 2 lines or more. Choroidal hyperpermeability was reduced in every case. Neurosensorial retinal detachment decreased in 80% of cases. Only one eye received a second PDT treatment due to choroidal neovascularization. An increase of atrophy over the Retinal Pigment Epithelium (RPE) was observed in another patient. CONCLUSIONS: PDT can reduce the clinical signs of activity, such as choroidal hyperpermeability or neurosensorial retinal detachment, in patients affected by chronic CSC. However, the increase in visual acuity is variable, probably due to the extent of RPE damage.

Terapia fotodinámica en coriorretinopatía serosa central crónica severa / Photodynamic therapy in severe chronic central serous chorioretinopaty

Objetivo: Determinar la eficacia y seguridad de la terapia fotodinámica en coriorretinopatía serosa central crónica (CSC) Métodos: Se incluyen pacientes con formas crónicas de CSC y signos de actividad de la enfermedad tratados con terapia fotodinámica. Se lleva a cabo una exploración oftamológica completa incluyendo la medida de mejor agudeza visual corregida (MAVC) en optotipo ETDRS, angiografía con fluoresceína (AFG) y verde de indocianina (AVI) y tomografía de coherencia óptica (OCT). El objetivo primario del estudio es determinar el cambio medio en agudeza visual. Resultados: Se han incluido 11 ojos de 11 pacientes. La MAVC media ha pasado de 20/76 a 20/64. El 35% de los ojos mejoraron su MAVC en dos o más líneas, en el 45% se mantuvo estable y el 18% perdieron dos o más líneas. En todos los casos se redujo la hiperpermeabilidad coroidea y en un 80% el desprendimiento de retina neurosensorial. Todos los pacientes recibieron un solo tratamiento salvo un caso que requirió dos por la aparición de una neovascularización coroidea (NVC). En otro caso tomograse apreció incremento de la atrofia sobre el epitelio pigmentario de la retina (EPR). El seguimiento medio ha sido de 11 meses. Conclusiones: La administración de TFD en pacientes con CSC crónica mejora especialmente los signos de actividad de la enfermedad, como la hiperpermeabilidad coroidea o el desprendimiento de retina neurosensorial. La mejoría en la agudeza visual, sin embargo, no es constante, probablemente debido a la alteración en el EPR

Objective: To determine the efficacy of Photodynamic Therapy (PDT) in chronic Central Serous Chorioretinopathy (CSC). Methods: Patients diagnosed with chronic CSC, with clinical evidence of activity and treated with Photodynamic Therapy, are included in this report. All were assessed by a complete ophthalmological examination, including assessment of the best corrected visual acuity (BCVA) using an ETDRS chart, fluorescein and indocyanine angiography and optical coherence tomography (OCT). The main objective of the study was to determine the mean visual acuity change. Results: 11 eyes of 11 patients were included in the study, which had a mean follow-up period of 11 months. The mean BCVA increased from 20/76 to 20/64. 35% of eyes improved their BCVA by 2 lines or more, 45% remained stable and 18% lost 2 lines or more. Choroidal hyperpermeability was reduced in every case. Neurosensorial retinal detachment decreased in 80% of cases. Only one eye received a second PDT treatment due to choroidal neovascularization. An increase of atrophy over the Retinal Pigment Epithelium (RPE) was observed in another patient. Conclusions: PDT can reduce the clinical signs of activity, such as choroidal hyperpermeability or neurosensorial retinal detachment, in patients affected by chronic CSC. However, the increase in visual acuity is variable, probably due to the extent of RPE damage

[Reduction of corneal permeability in patients treated with HP-guar: a fluorophotometric study]. / Reducción de la permeabilidad corneal en pacientes tratados con HP-guar: estudio fluorofotométrico.

INTRODUCTION: The incidence of dry eye disease, which mainly affects the corneal epithelium, is rising. The main treatment is still the use of artificial tears capable of improving the humidification and lubrication of the corneal epithelium, and avoiding its progressive functional failure. HP-Guar is a new compound used for this purpose. METHODS: We performed a prospective, masked and paired study on the left eye of 10 patients suffering from dry eye disease. Corneal permeability measurements were performed by fluorophotometry after instilling 40 microL of a solution of 2% sodium fluorescein, before and after treatment with the HP-Guar drops. The results were analysed using Wilcoxon test for paired data. RESULTS: A mean decrease in corneal permeability of 45%, after the use of HP-Guar drops was found (p=0.002). CONCLUSIONS: HP-Guar provides a new therapeutic option significantly decreasing corneal epithelial permeability.

Reducción de la permeabilidad corneal en pacientes tratados con HP-Guar: estudio fluorofotométrico / Reduction of corneal permeability in patients treated with HP-Guar: a fluorophotometric study

Introducción: El ojo seco es una enfermedad en laque entre otras estructuras se afecta el epitelio corneal.El tratamiento de primera línea siguen siendolos sustitutivos lagrimales que buscan lograr unabuena humidificación y lubricación del epitelio cornealde estos pacientes, evitando así su progresivodeterioro funcional. El HP-Guar es un compuestonovedoso cuyos resultados sintomáticos en lospacientes con ojo seco están siendo prometedores.Métodos: Presentamos un estudio prospectivo,enmascarado, pareado sobre 10 ojos izquierdos de10 pacientes con ojo seco, a los que se les realizómedidas de la permeabilidad corneal mediante fluorofotometríacon la instilación de 40 microlitros deuna solución de fluoresceína sódica al 2%, antes ydespués del tratamiento con HP-Guar. Se analizaronlos resultados con el test de Wilcoxon paradatos pareados. Resultados: Se observó tuvo una disminución estadísticamentesignificativa de la permeabilidad cornealmedia del 45% tras tratamiento con HP-Guar(p= 0,002).Conclusiones: El HP-Guar constituye una nuevaopción terapéutica que ha demostrado fluotofotométricamentereducir la permeabilidad epitelial cornealtras su uso

Introduction: The incidence of dry eye disease, which mainly affects the corneal epithelium, is rising. The main treatment is still the use of artificial tears capable of improving the humidification and lubrication of the corneal epithelium, and avoiding its progressive functional failure. HP-Guar is a new compound used for this purpose. Methods:We performed a prospective, masked and paired study on the left eye of 10 patients suffering from dry eye disease. Corneal permeability measurements were performed by fluorophotometry after instilling 40 mL of a solution of 2% sodium fluorescein, before and after treatment with the HP-Guar drops. The results were analysed using Wilcoxon test for paired data. Results: A mean decrease in corneal permeability of 45%, after the use of HP-Guar drops was found (p=0.002). Conclusions: HP-Guar provides a new therapeutic option significantly decreasing corneal epithelial permeability