RESUMEN
Pancreatic pseudocyst-portal vein fistulae are a very rare complication of acute or chronic pancreatitis. Another late complication of chronic pancreatitis is pancreatic ascites. We report the case of a 43-year-old man with a spontaneous pseudocyst-portal vein fistula presenting with pancreatic ascites diagnosed by various imaging modalities, in order to emphasize the strength and efficacy of magnetic resonance cholangiopancreatography.
Asunto(s)
Ascitis/diagnóstico , Fístula Pancreática/diagnóstico , Seudoquiste Pancreático/diagnóstico , Vena Porta , Fístula Vascular/diagnóstico , Adulto , Ascitis/etiología , Colangiopancreatografia Retrógrada Endoscópica , Pancreatocolangiografía por Resonancia Magnética , Humanos , Masculino , Seudoquiste Pancreático/complicaciones , Pancreatitis Alcohólica/complicaciones , Tomografía Computarizada por Rayos X , Fístula Vascular/complicacionesRESUMEN
Although it has been well known that the role of LPS on hepatotoxicity is mediated through TNF-alpha, the direct cytotoxic effect of LPS on IFN-gamma-primed hepatocytes has not yet been clearly demonstrated. Here, we demonstrate that the IFN-gamma-mediated death of murine embryonic liver BNL CL2 cells is potentiated by LPS (0.5 microg/ml). In addition, an exogenous NO donor, sodium nitroprusside (SNP) significantly prevents cell death induced by IFN-gamma alone or IFN-gamma plus LPS (IFN-gamma/LPS) in a dose-dependent manner over 25 microM. SNP significantly blocked the death of BNL CL2 cells only when it was added within 12 hr after treatment of IFN-gamma and IFN-gamma/LPS. The preventive effect of SNP occurred in parallel with the suppression of caspase 3-like protease activation. We have also demonstrated that a relatively high concentration as well as an appropriate period of exposure to NO may be critical to maintain cell viability from the cytotoxic effect of IFN-gamma and IFN-gamma/LPS. Furthermore, the preventive effect of SNP on IFN-gamma/LPS-induced cell death is mediated by a protein kinase G (PKG)-independent manner.
Asunto(s)
Hepatocitos/efectos de los fármacos , Interferón gamma/toxicidad , Lipopolisacáridos/toxicidad , Óxido Nítrico/fisiología , Animales , Caspasa 3 , Caspasas/metabolismo , Muerte Celular/efectos de los fármacos , Muerte Celular/fisiología , Línea Celular , GMP Cíclico/metabolismo , Proteínas Quinasas Dependientes de GMP Cíclico/metabolismo , Activación Enzimática/efectos de los fármacos , Hepatocitos/patología , Hepatocitos/fisiología , Ratones , Óxido Nítrico/biosíntesis , Donantes de Óxido Nítrico/farmacología , Nitroprusiato/farmacología , Proteínas RecombinantesRESUMEN
WHIM syndrome is a rare congenital familial syndrome consisting of warts, hypogammaglobulinemia, infections, and myelokathexis. We describe a 30-year-old man with WHIM syndrome, in whom red dermal facial nodules developed. The diagnosis of B-cell lymphoma was established with biopsy and immunohistochemical studies. To our knowledge, this is the first reported case of WHIM syndrome complicated by a B-cell lymphoma.
Asunto(s)
Agammaglobulinemia/complicaciones , Linfoma de Células B/complicaciones , Neoplasias Cutáneas/complicaciones , Verrugas/complicaciones , Adulto , Humanos , Infecciones/complicaciones , Masculino , SíndromeAsunto(s)
Inmunoglobulinas Intravenosas/uso terapéutico , Trasplante de Riñón , Infecciones por Parvoviridae/diagnóstico , Parvovirus B19 Humano , Complicaciones Posoperatorias/virología , Aplasia Pura de Células Rojas/virología , Adulto , Anticuerpos Antivirales/sangre , Médula Ósea/patología , ADN Viral/análisis , Células Madre Hematopoyéticas/patología , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Masculino , Infecciones por Parvoviridae/tratamiento farmacológico , Parvovirus B19 Humano/aislamiento & purificación , Resultado del TratamientoRESUMEN
OBJECTIVE. We describe the CT and pathologic features of malignant papillary neoplasms of the intrahepatic bile ducts in 15 patients. CONCLUSION. CT is a useful technique for revealing intraductal lesions, although the findings are nonspecific and variable. When intraductal masses or nodules are seen with localized dilatation of the intrahepatic bile ducts on CT scans, malignant papillary neoplasms of the intrahepatic bile ducts should be included in the differential diagnosis.
