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1.
J Clin Microbiol ; 50(11): 3738-40, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22915602

RESUMEN

Experimental challenge protocols that consistently reproduce clinical signs of peste des petits ruminants in Alpine goats infected with a tissue culture-passaged peste des petits ruminants virus are described. The protocols can be used to carry out quality-controlled vaccine efficacy and pathogenesis studies under experimental conditions.


Asunto(s)
Modelos Animales de Enfermedad , Peste de los Pequeños Rumiantes/patología , Peste de los Pequeños Rumiantes/virología , Virus de la Peste de los Pequeños Rumiantes/patogenicidad , Animales , Cabras
2.
Vet Microbiol ; 160(1-2): 240-4, 2012 Nov 09.
Artículo en Inglés | MEDLINE | ID: mdl-22633480

RESUMEN

Peste des petits ruminants virus (PPRV) recently caused a serious outbreak of disease in Moroccan sheep and goats. Alpine goats were highly susceptible to PPRV with mortality rates approaching 100%, as opposed to local breeds of sheep which were less susceptible to the disease. The relative susceptibility of alpine goats was investigated through an experimental infection study with the Moroccan strain of PPRV. Severe clinical signs were observed in the alpine goats with virus being excreted through ocular, nasal and oral routes. No difference in the severity of the disease in goats was observed with different inoculation routes and transmission of the virus by direct contact was confirmed. This study confirmed the susceptibility of the alpine goat to PPRV infection and describes a challenge protocol that effectively and consistently reproduced severe clinical signs of PPR in experimentally infected goats.


Asunto(s)
Brotes de Enfermedades/veterinaria , Enfermedades de las Cabras/virología , Peste de los Pequeños Rumiantes/veterinaria , Virus de la Peste de los Pequeños Rumiantes/aislamiento & purificación , Enfermedades de las Ovejas/virología , Animales , Enfermedades de las Cabras/epidemiología , Cabras , Marruecos/epidemiología , Peste de los Pequeños Rumiantes/epidemiología , Peste de los Pequeños Rumiantes/virología , Ovinos , Enfermedades de las Ovejas/epidemiología , Oveja Doméstica , Vacunación
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