Optimizing City-Scale Demolition Waste Supply Chain Under Different Carbon Policies.

In order to establish a green, low-carbon circular development economic system, imperative goals include achieving carbon peaking and carbon neutrality. This research delves into the resource utilization of city-scale demolition waste (C&DW), aligning with environmental protection needs and sustainable development principles. The paper introduces a unique closed-loop supply chain (CLSC) model tailored for C&DW and employs a distinctive mixed integer nonlinear programming (MINLP) model for optimization. Guangzhou serves as a case study for thorough analysis, verification, and practical application of the proposed model, especially under diverse scenarios of carbon price (CP) and carbon trading (CT) policies. The key conclusions drawn from this study include the following: (1) The cost of carbon emissions is intricately influenced by both carbon emissions and carbon price, with the latter effectively regulating the carbon emissions during C&DW recycling. (2) The implementation of a CT policy, with a fixed carbon price, contributes to a further reduction in the cost of C&DW recycling treatment. (3) Under equivalent conditions, the CT policy demonstrates the potential to decrease costs and enhance the economic benefits within the building environmental protection product market. The research outcomes not only contribute to the advancement of management theory in the C&DW recycling supply chain (SC) but also provide a robust theoretical foundation for governmental initiatives aimed at introducing effective C&DW recycling management policies.

Natural Terpenes as Penetration Enhancers for Transdermal Drug Delivery.

The greatest hindrance for transdermal drug delivery (TDD) is the barrier property of skin, especially the stratum corneum (SC). Various methodologies have been investigated and developed to enhance the penetration of drugs through the skin. Among them, the most popular approach is the application of penetration enhancers (PEs), including natural terpenes, a very safe and effective class of PEs. In the present paper, we focused on terpenes as skin PEs for TDD. The mechanism of their action, the factors affecting their penetration enhancement effect, as well as their possible skin toxicity were discussed. Terpenes abundant in nature have great potential in the development of PEs. Compared to synthetic PEs, natural terpenes have been proved to possess higher enhancement activity. Interaction with SC intercellular lipids is the main mechanism of action for terpenes. The key factor affecting the enhancement effect is the lipophilicity of both terpenes and drug molecules. In addition, a lot of terpenes have also been proved to be much less toxic compared to azone, the classic synthetic PE. In summary, terpenes may be preferred over the chemically synthesized compounds as safe and effective PEs to promote the percutaneous absorption of drugs.