Bio-based polymers containing traditional medicinal fillers for wound healing applications - An evaluation of neoteric development and future perspectives.

In recent years, health-care providers have seen more patients with difficult-to-treat wounds and burns. The biopolymer-based wound dressing protects the wounded area while assisting in the recovery of dermal and epithelial tissues throughout the healing process. The overall number of patients with chronic lesions has been expanding due to developing society, over weight, and cardiovascular illness. For the treatment of chronic wounds, there is an increasing demand for the development of ideal wound dressing materials with excellent properties such as antibacterial activity, biocompatibility, free radical scavenging capacity, non-adherent property, hydrophilicity, and so on. Nevertheless, owing to the above mention properties, natural polymers are being used for several key functions of biomedicine like narcotic distribution systems, tissue manufacturing, bandages, and so on. Accordingly, the significance of these bio-based polymers interfered with healing functions that lead to informing and inspiring youth and scientist researchers worldwide to grab with these far-reaching areas of medicine and biology. The review highlights the physiochemical properties of natural polymers, the biological evaluation of various materials as wound dressings, their synthesis and mechanical properties, clinical status, challenges, and future perspectives.

Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL).

BACKGROUND: Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to collect data on the use of the magnetic resonance linear accelerator (MR-Linac) for radiation therapy and patient outcomes. The registry will provide a linked repository of technical and clinical data that will form a platform for prospective studies and technology assessment. METHODS: Design: This registry aims to include an estimated 10,000 eligible participants across Australia and other countries over a 7- to 10-year period. Participants will undergo treatment and assessments in accordance with standard practice. Toxicity and survival outcomes will be assessed at baseline, during treatment, and with 3 monthly follow-up until 24 months, patient reported outcome measures will also be collected. Participants with a variety of cancers will be included. DISCUSSION: Data obtained from the ADAPT-MRL registry is expected to provide evidence on the safety and efficacy of the MR-Linac, a new technical innovation in radiation oncology. We expect this registry will generate data that will be used to optimise treatment techniques, MR-Linac software algorithms, evaluate participants' outcomes and toxicities and to create a repository of adapted plans, anatomical and functional MR sequences linked to participants' outcomes.

Phytofiltration of cadmium from water by Limnocharis flava (L.) Buchenau grown in free-floating culture system.

A hydroponics experiment was conducted to examine the phytofiltration of Cd by Limnocharis flava (L.) Buchenau grown in low-level Cd-contaminated water. For this, 45 d old seedlings of L .flava were transferred to a floating-support culture system containing nutrient solution spiked with four levels of Cd (0.5, 1, 2 and 4 mg l(-1)) and were separately harvested after 3, 7, 21 and 30 d. After 30 d harvesting, the percentage removal of Cd from the above four treatments reached up to 98, 96, 95 and 93%, respectively. Interestingly, all treatments had higher growth rate than control at 95% confidence level and plants still remained healthy at 4 mg l(-1) Cd exposure. The bioaccumulation study showed a linear relationship of Cd (R(2)=0.896-0.999) in all plant parts with the exposure time (3-30 d) and Cd concentrations in hydroponics system (0.5-4 mg l(-1)). Although, the root of L. flava had higher Cd concentration than leaf and peduncles, the total Cd concentrations in aerial plant parts were higher than the roots. The maximum bioconcentration factor (BCF) and translocation factor (TF) value of L. flava were calculated as 984.42 and 1.43, respectively. Estimated Cd accumulation capacity of L. flava per unit area (m(2)) was found to be in the range of 218. 35-1698.92 mg m(-2).The experimental results demonstrated that L. flava is a suitable candidate for the phytofiltartion (>93%) of Cd from low-level Cd-contaminated water.