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Bioorg Med Chem Lett
; 14(22): 5481-4, 2004 Nov 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15482908
RESUMEN
Structure-activity relationship studies focused on bio-isosteric replacements of 2-pyridyl resulted in mGlu5 receptor antagonists with reduced inhibition of cytochrome P450 1A2. This led to highly potent, selective and orally bioavailable 2-imidazolyl tetrazoles such as (10) that are devoid of cytochrome P450 inhibitory activity.