RESUMEN
A female patient with xeroderma pigmentosum and multiple basal cell carcinomas was treated with a hedgehog pathway inhibitor (vismodegib), which successfully treated the majority of her basal cell carcinomas while preventing the appearance of new lesions. The sum diameter of lesions showed a 61% decrease after 16.5 months of treatment, although after 18.5 months of treatment, a persistent lesion showed progression and metatypical characteristics; adverse events included persistent alopecia muscle cramps, dysgeusia, and amenorrhea. Despite these limitations, vismodegib may have a role in the treatment of some patients with xeroderma pigmentosum.
Asunto(s)
Anilidas/uso terapéutico , Antineoplásicos/uso terapéutico , Carcinoma Basocelular/tratamiento farmacológico , Síndrome de Hamartoma Múltiple/tratamiento farmacológico , Piridinas/uso terapéutico , Neoplasias Cutáneas/tratamiento farmacológico , Xerodermia Pigmentosa/complicaciones , Adulto , Anilidas/efectos adversos , Antineoplásicos/efectos adversos , Carcinoma Basocelular/complicaciones , Femenino , Síndrome de Hamartoma Múltiple/complicaciones , Humanos , Piridinas/efectos adversos , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/patologíaAsunto(s)
Melanoma/patología , Neoplasias Cutáneas/patología , Adolescente , Antineoplásicos/uso terapéutico , Quimioterapia Adyuvante , Niño , Femenino , Humanos , Interferón-alfa/uso terapéutico , Masculino , Melanoma/tratamiento farmacológico , Melanoma/mortalidad , Estadificación de Neoplasias , Pronóstico , Estudios Retrospectivos , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/mortalidad , Tasa de Supervivencia , Adulto JovenAsunto(s)
Adenocarcinoma/tratamiento farmacológico , Hipertricosis/inducido químicamente , Neoplasias Pulmonares/tratamiento farmacológico , Inhibidores de Proteínas Quinasas/efectos adversos , Quinazolinas/efectos adversos , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico , Receptores ErbB/antagonistas & inhibidores , Clorhidrato de Erlotinib , Pestañas , Cara , Femenino , Humanos , Persona de Mediana EdadRESUMEN
Melanin-like pigment produced in vitro and in vivo by Malassezia yeasts has not been described before. Masson-Fontana staining confirmed accumulation of black pigment on the cell walls of L-dihydroxyphenylalaline (L-DOPA)-cultured Malassezia species. Black pigment was also observed in cells and hyphae from hyperpigmented patient lesions with culture-confirmed pityriasis versicolor and seborrheic dermatitis.