1.
Org Biomol Chem
; 19(48): 10560-10564, 2021 12 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34870670
RESUMEN
The enantioselective hydrophosphonylation of N-Boc imines was investigated using a new family of pseudo-symmetric guanidine-thiourea catalysts, providing α-amino phosphonates in moderate to high yields with good enantioselectivity. The catalyst was heterogenized by polymerization with styrene and the resulting catalyst was applied to reactions under continuous-flow conditions.