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Bioorg Med Chem Lett
; 16(11): 2905-8, 2006 Jun 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16580205
RESUMEN
A series of 2,5-cis-disubstituted pyrrolidines were synthesized and evaluated as S1P receptor agonists. Compounds 15-21 were identified with good selectivity over S1P3 which lowered circulating lymphocytes after oral administration in mice.