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Fitoterapia ; 138: 104350, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31473333

RESUMEN

Three new bibenzyl derivatives (bletstrins A-C, 1-3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilla striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 µg/mL) against S. aureus ATCC 6538.


Asunto(s)
Antibacterianos/farmacología , Orchidaceae/química , Tubérculos de la Planta/química , Estilbenos/farmacología , Antibacterianos/aislamiento & purificación , Bibencilos/aislamiento & purificación , Bibencilos/farmacología , China , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Fitoquímicos/aislamiento & purificación , Fitoquímicos/farmacología , Staphylococcus aureus/efectos de los fármacos , Estilbenos/aislamiento & purificación
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