Through-Holes Design for Ideal LiNbO3 A1 Resonators.

This paper proposes a method to realize ideal lithium niobate (LiNbO3) A1 resonators. By introducing subwavelength through-holes between the interdigital transducer (IDT) electrodes on the LiNbO3 surface, all unfavorable spurious modes of the resonators can be suppressed completely. It is convenient and valid for various IDT electrode parameters and different LiNbO3 thicknesses. Also, this method does not require additional device fabrication steps. At the same time, these through-holes can greatly reduce the suspended area of the LiNbO3 thin film, thus significantly improving the design flexibility, compactness, mechanical stability, temperature stability, and power tolerance of the resonators (and subsequent filters). It is expected to become an important means to promote the practical application of LiNbO3 A1 filters and even all Lamb waves filters.

Extended topological valley-locked surface acoustic waves.

Stable and efficient guided waves are essential for information transmission and processing. Recently, topological valley-contrasting materials in condensed matter systems have been revealed as promising infrastructures for guiding classical waves, for they can provide broadband, non-dispersive and reflection-free electromagnetic/mechanical wave transport with a high degree of freedom. In this work, by designing and manufacturing miniaturized phononic crystals on a semi-infinite substrate, we experimentally realized a valley-locked edge transport for surface acoustic waves (SAWs). Critically, original one-dimensional edge transports could be extended to quasi-two-dimensional ones by doping SAW Dirac "semimetal" layers at the boundaries. We demonstrate that SAWs in the extended topological valley-locked edges are robust against bending and wavelength-scaled defects. Also, this mechanism is configurable and robust depending on the doping, offering various on-chip acoustic manipulation, e.g., SAW routing, focusing, splitting, and converging, all flexible and high-flow. This work may promote future hybrid phononic circuits for acoustic information processing, sensing, and manipulation.

Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Study / 中国结合医学杂志

OBJECTIVE@#To assess the efficacy and safety of mulberry twig alkaloids (Sangzhi alkaloids, SZ-A) for treatment of type 2 diabetes in a randomized, double-blind, placebo-controlled multicenter clinical trial.@*METHODS@#A total of 200 patients were randomized to receive SZ-A (n=100) or placebo (n=100) for 16 weeks. The data analysis system for electronic data capture clinical trial central randomization system was used for randomization and dispensing of drugs. The primary outcome was the change in glycosylated hemoglobin (HbA1c) level. The secondary outcome included the proportions of cases with HbA1c <7.0% and HbA1c <6.5%, fasting blood glucose (FBG), postprandial blood glucose (PBG), area under curve for the PBG (AUC0-2h), body weight, and body mass index (BMI). Adverse events (AEs), severe adverse events (SAEs), treatment-related adverse events (TAEs), gastrointestinal disorders (GDs), blood pressure, routine blood tests, and liver and kidney function were monitored.@*RESULTS@#Compared with baseline, the change of HbA1c at week 16 was -0.80% (95% CI: -0.98% to -0.62%) and -0.09% (95% CI: -0.27% to 0.09%) in SZ-A group and placebo group, respectively. The proportion of patients with HbA1c <7% and <6.5% was higher in the SZ-A group than in the placebo group (46.8% vs. 21.6% and 29.9% vs. 10.8%). The observed values and changes in FBG, 1 h-PBG, 2 h-PBG, and AUC0-2h differed significantly between groups (P<0.001), but differences were not significant in body weight and BMI (P>0.05). The incidence rates of AEs, TAEs, and GDs differed significantly between groups (P=0.010, P=0.005, and P=0.006, respectively), whereas the incidence rates of SAEs showed no significant differences between groups (P=1.000).@*CONCLUSION@#SZ-A are effective and safe for treatment of type 2 diabetes. The protocol was registered in http://www.chictr.org.cn/showproj.aspx?proj=60117 (ChiCTR2000038550).

[Decomposition of driving factors of industry-related CO2 emissions and its decoupling with economic growth in Fujian Province, China]. / ç¦å»ºçœè¡Œä¸šç¢³æŽ’æ”¾é©±åŠ¨å› ç´ åˆ†è§£åŠå ¶ä¸Žç»æµŽå¢žé•¿è„±é’©å ³ç³».

The emission of CO2 from major sectors and key industries are the predominant sources of regional CO2 emissions. It is the prerequisite to promote sectoral carbon emissions reduction, to cla-rify their influencing factors and investigate their relationship with regional economic growth. It is also of great significance for the implementation of regional total carbon emissions control. Using the Logarithmic mean Divisia index method (LMDI) and the Tapio decoupling model, we analyzed the driving factors, and decoupling status with economic growth of 13 major carbon emissions industries in Fujian Province from 1997 to 2017. The results showed that the electricity and heat production and supply industry was the major source of CO2 emissions in Fujian Province, with an increase of 101.74 Mt (from 18.89 Mt to 120.63 Mt) during the period 1997 to 2017. The top three industries with the fastest annual growth rate in CO2 emissions were non-ferrous metal smelting and rolling processing industry (18.1%), textile industry (12.1%), and ferrous metal smelting and rolling processing industry (12.1%). Among the influence factors for the changes in carbon emissions in 13 major industries, economic growth effect and population scale effect were the main positive driving factors, while the restraining effects of energy structure, energy intensity, and industrial structure were continuously increasing. In terms of decoupling relationship, the decoupling index between economic growth and industry-related CO2 emissions showed a downward trend on the whole. Since the 11th Five-Year-Plan period, some industries had begun to show strong decoupling to some extent. The farming, forestry, animal husbandry, fishery and water conservancy industry exhibited expansive negative decoupling, whereas the electricity and heat production and supply industry exhibited weak negative decoupling during 13th Five-Year Plan period. The effects of energy structure and energy intensity had substantial impacts on the decoupling with economic growth for various industries. The industrial structure effect had a smaller impact on the decoupling with economic growth, while the population scale effect had almost no impact.