[Infection in Children with Acute Myeloid Leukemia in the Intensive Chemotherapy Period].

OBJECTIVE: To investigate the clinical characteristics of infection in children with acute myeloid leukemia (AML) after high intensive chemotherapy， so as to provide reference for prevention and control of infection. METHODS: 56 children diagnosed as acute myeloid leukemia in our hospital from January 2016 to August 2019 were enrolled and retrospectively analyzed, the infection rate, pathogens of disease and common location of infection during the induction and consolidation period were analyzed. RESULTS: The total infection rate of the patients was 93.4%－96.4%, the average of serious infection rate was 16.0%(11.3%－19.6%), and the infection related mortality was 10.7%. Fever of unknown cause was the main reason of infection, while blood flow infections were the most common in severe infection, which were mainly caused by Gramnegative bacteria. The rate of fungal infection was 35.7% during chemotherapy. CONCLUSION: Children with AML shows a high incidence of infection in each stage of chemotherapy. The serious illness caused by blood flow infection and take antifungal drugs to reduce the occurrence of fungal infection in AML patients should be paid attention.

[The differential features of bone marrow morphology of several rare infectious disorders].

OBJECTIVE: To facilitate the diagnosis of histoplasmosis, kala-azar, penicilliosis marneffei, toxoplasmosis and cryptococcosis with the help of bone marrow morphology. METHOD: The clinical features and bone marrow cytomorphology in 7 cases of histoplasmosis, 1 case of kela-azar, 1 case of penicilliosis marneffei, 2 cases of toxoplasmosis and 3 cases of cryptococcosis were studied. RESULTS: In the bone marrow examination, the form of histoplasma capsule was ovoid with a colorless circle. The morphology of Leishmania donovani was similar to that of histoplasma capsule except that there were terkinetoplasts present in the former. Sausage form and central cross wall were signs of Penicillium marneffei. Toxoplasma gondii looked like a banana and cryptococcus neoformans was larger than the others and had a thick capsule. CONCLUSION: The examination of bone marrow is important to the diagnosis of these rare infectious diseases.