1.
Bioorg Med Chem Lett
; 15(8): 1979-82, 2005 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15808451
RESUMEN
A practical diastereoselective synthetic method for 8018 enantiopure isomers is described. The intramolecular asymmetric epoxidation of mono-sulfonate 4 was applied for the execution of the synthesis of the key chiral building block for the first time. The isomers were obtained with 70-76% yields in 99-100% ee.