Risk of Dental Implant Failures May Be Higher in Bruxers Than Nonbruxers.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Häggman-Henrikson B, Ali D, Aljamal M, Chrcanovic BR. Bruxism and dental implants: A systematic review and meta-analysis. J Oral Rehabil. 2024 Jan;51(1):202-217. 10.1111/joor.13567. Epub 2023 Aug 17. PMID: 37589382. SOURCE OF FUNDING: None. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling.

PURPOSE: Genetic counseling (GC) is standard of care in genetic cancer risk assessment (GCRA). A rigorous assessment of the data reported from published studies is crucial to ensure the evidence-based implementation of GC. METHODS: We conducted a systematic review and meta-analysis of 17 patient-reported and health-services-related outcomes associated with pre- and post-test GC in GCRA in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. RESULTS: Twenty-five of 5393 screened articles met inclusion criteria. No articles reporting post-test GC outcomes met inclusion criteria. For patient-reported outcomes, pre-test GC significantly decreased worry, increased knowledge, and decreased perceived risk but did not significantly affect patient anxiety, depression, decisional conflict, satisfaction, or intent to pursue genetic testing. For health-services outcomes, pre-test GC increased correct genetic test ordering, reduced inappropriate services, increased spousal support for genetic testing, and expedited care delivery but did not consistently improve cancer prevention behaviors nor lead to accurate risk assessment. The GRADE certainty in the evidence was very low or low. No included studies elucidated GC effect on mortality, cascade testing, cost-effectiveness, care coordination, shared decision making, or patient time burden. CONCLUSION: The true impact of GC on relevant outcomes is not known low quality or absent evidence. Although a meta-analysis found that pre-test GC had beneficial effects on knowledge, worry, and risk perception, the certainty of this evidence was low according to GRADE methodology. Further studies are needed to support the evidence-based application of GC in GCRA.

SMOKING MAY BE STRONGLY ASSOCIATED WITH PERI­IMPLANTITIS.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Reis INRD, do Amaral GCLS, Hassan MA, Villar CC, Romito GA, Spin-Neto R, Pannuti CM. The influence of smoking on the incidence of peri­implantitis: A systematic review and meta-analysis. Clin Oral Implants Res. 2023 Mar 20. doi:10.1111/clr.14066. Epub ahead of print. PMID: 36,939,434. SOURCE OF FUNDING: None reported. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

PROXIMAL CONTACT LOSS MAY BE A FREQUENT COMPLICATION IN IMPLANT-SUPPORTED RESTORATIONS.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Manicone PF, De Angelis P, Rella E, Papetti L, D'Addona A. Proximal Contact Loss in Implant-Supported Restorations: A Systematic Review and Meta-Analysis of Prevalence. J Prosthodont. 2022 Mar;31(3):201-209. doi:10.1111/jopr.13407. Epub 2021 Aug 5. PMID: 34263959 SOURCE OF FUNDING: Not reported. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

THE PROPORTION OF ORAL LICHEN PLANUS CASES WITH MALIGNANT TRANSFORMATION MAY BE HIGHER, THAN REPORTED TO DATE.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: González-Moles MÁ, Ramos-García P, Warnakulasuriya S. An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review. Oral Dis. 2021 Nov;27(8):1908-1918. doi: 10.1111/odi.13741. Epub 2020 Dec 24. PMID: 33274561. SOURCE OF FUNDING: The Royal College of Physicians and Surgeons (RCPSG) provided logistic support for holding the expert symposium. Henry Schein Cares provided an educational grant for travel expenses for some of the invited experts. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

INDOCYANINE GREEN-MEDIATED PHOTODYNAMIC THERAPY MAY BE AN EFFECTIVE ADJUNCT TO NON-SURGICAL PERIODONTAL THERAPY AT 3- AND 6-MONTHS POST-THERAPY.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Bashir NZ, Singh HA, Virdee SS. Indocyanine green-mediated antimicrobial photodynamic therapy as an adjunct to periodontal therapy: a systematic review and meta-analysis. Clin Oral Investig. 2021 Mar 12. doi: 10.1007/s00784-021-03871-2. Epub ahead of print. PMID: 33710461. SOURCE OF FUNDING: Information not available. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

ACCESS FLAPS MAY RESULT IN GREATER POCKET REDUCTION THAN SUBGINGIVAL DEBRIDEMENT FOR DEEP POCKETS BUT MAY NOT BE BENEFICIAL FOR SHALLOW TO MODERATELY DEEP POCKETS.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Sanz-Sánchez I, Montero E, Citterio F, Romano F, Molina A, Aimetti M. Efficacy of access flap procedures compared to subgingival debridement in the treatment of periodontitis. A systematic review and meta-analysis. J Clin Periodontol. 2020 Jul;47 Suppl 22:282-302. doi:10.1111/jcpe.13259. PMID: 31,970,821. SOURCE OF FUNDING: This systematic review was self-funded. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

Limited Evidence Suggests About One in Five Potentially Premalignant Oral Lesions Is Related to Human Papillomavirus.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis. de la Cour CD, Sperling CD, Belmonte F, Syrjänen S, Kjaer SK. Oral Dis. 2020 Mar 6. https://doi.org/10.1111/odi.13322. Epub ahead of print. PMID: 32144837. SOURCE OF FUNDING: None. The authors have no actual or potential conflicts of interest. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

Individuals With Gastroesophageal Reflux Disease or Symptoms May Have Increased Odds of Erosive Tooth Wear.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The association between erosive toothwear and gastro-oesophageal reflux-related symptoms and disease: A systematic review and meta-analysis. Jordão HWT, Coleman HG, Kunzmann AT, McKenna G. J Dent 2020. https://doi.org/10.1016/j.jdent.2020.103284. SOURCE OF FUNDING: None. The authors declared no conflict of interest. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

Smoking May Increase the Risk of Periapical Periodontitis.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The association between smoking and periapical periodontitis: a systematic review. Aminoshariae A, Kulild J, Gutmann J.Clin Oral Investig 2020;24(2):533-545. https://doi.org/10.1007/s00784-019-03094-6. SOURCE OF FUNDING: None. The authors declared no conflict of interest. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

Systemic Intake of Proton Pump Inhibitors and Selective Serotonin Reuptake Inhibitors May Be Associated With Implant Failure.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Medication-related dental implant failure: Systematic review and meta-analysis. Chappuis V, Avila-Ortiz G, Araújo MG, Monje A. Clin Oral Implants Res 2018;29 Suppl 16:55-68. SOURCE OF FUNDING: None. The authors declared no conflict of interest. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.

Limited Evidence Suggests That Patients With Recurrent Aphthous Stomatitis May Benefit From Using Sodium Lauryl Sulfate-free Dentifrices.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: A systematic review. Alli BY, Erinoso OA, Olawuyi AB. J Oral Pathol Med. 2019;48(5):358-64. SOURCE OF FUNDING: None. The authors declared no conflict of interest. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data from double-blind randomized controlled trials.

Mannitol to prevent cisplatin-induced nephrotoxicity in patients with squamous cell cancer of the head and neck (SCCHN) receiving concurrent therapy.

PURPOSE: The purpose of this study is to compare the incidence and severity of nephrotoxicity in patients receiving cisplatin with saline hydration vs. saline hydration with mannitol. METHODS: Retrospective chart review of all patients receiving a starting dose of cisplatin 100 mg/m(2) with concurrent radiation for SCCHN between January 1, 2009 and March 1, 2013. All patients received pre and post hydration each with 1 l of 0.9 % saline. The mannitol group received 12.5 g of mannitol in the prehydration fluid. The primary outcome was to compare the rate of grade 3 or greater serum creatinine (SCr) increase in patients receiving saline hydration vs. the addition of mannitol; additional parameters of interest included creatinine clearance, electrolyte disturbances, dose changes, and discontinuation of cisplatin. RESULTS: Data from 139 patients (80 % male) with a median age of 56 years (range 22 to 75 years) were collected; 88 received mannitol and 51 received saline alone. On multivariable analysis, the mannitol group was less likely to have grade 3 SCr increase than saline only group (OR 0.16; 95 % CI 0.04-0.65; p value = 0.01). There were no grade 4 SCr increase events. Rates of hypomagnesemia and hypokalemia were similar across groups. Grade 3 hyponatremia was more likely to occur in the mannitol group as compared to saline alone group (41 vs 22 %; p = 0.026). CONCLUSION: The addition of mannitol to saline hydration decreased the incidence of grade 3 increases in SCr in this cohort of patients and may increase rates of hyponatremia. Further investigations of methods to lessen cisplatin-induced nephrotoxicity are needed.