Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives.

Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis is characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. Ferroptosis is involved in a variety of physiological and pathological processes. Since its discovery, ferroptosis has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress and prospects, summarize the regulatory mechanisms of ferroptosis, and discuss the role of ferroptosis in the pathogenesis of bone-related diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), and osteosarcoma (OS), as well as its therapeutic potential.

CD4+ T-cell subsets in autoimmune hepatitis: A review.

Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis of AIH requires the identification of lymphoblast cell interface hepatitis and serum biochemical abnormalities, as well as the exclusion of related diseases. According to different specific autoantibodies, AIH can be divided into AIH-1 and AIH-2. The first-line treatment for AIH is a corticosteroid and azathioprine regimen, and patients with liver failure require liver transplantation. However, the long-term use of corticosteroids has obvious side effects, and patients are prone to relapse after drug withdrawal. Autoimmune diseases are characterized by an imbalance in immune tolerance of self-antigens, activation of autoreactive T cells, overactivity of B cells, and increased production of autoantibodies. CD4+ T cells are key players in adaptive immunity and can secrete cytokines, activate B cells to produce antibodies, and influence the cytotoxicity of CD8+ T cells. According to their characteristics, CD4+ T cells can be divided into different subsets. In this review, we discuss the changes in T helper (Th)1, Th2, Th17, Th9, Th22, regulatory T cell, T follicular helper, and T peripheral helper cells and their related factors in AIH and discuss the therapeutic potential of targeting CD4+ T-cell subsets in AIH.

Southern Ocean warming and its climatic impacts.

The Southern Ocean has warmed substantially, and up to early 21st century, Antarctic stratospheric ozone depletion and increasing atmospheric CO2 have conspired to intensify Southern Ocean warming. Despite a projected ozone recovery, fluxes to the Southern Ocean of radiative heat and freshwater from enhanced precipitation and melting sea ice, ice shelves, and ice sheets are expected to increase, as is a Southern Ocean westerly poleward intensification. The warming has far-reaching climatic implications for melt of Antarctic ice shelf and ice sheet, sea level rise, and remote circulations such as the intertropical convergence zone and tropical ocean-atmosphere circulations, which affect extreme weathers, agriculture, and ecosystems. The surface warm and freshwater anomalies are advected northward by the mean circulation and deposited into the ocean interior with a zonal-mean maximum at ∼45°S. The increased momentum and buoyancy fluxes enhance the Southern Ocean circulation and water mass transformation, further increasing the heat uptake. Complex processes that operate but poorly understood include interactive ice shelves and ice sheets, oceanic eddies, tropical-polar interactions, and impact of the Southern Ocean response on the climate change forcing itself; in particular, limited observations and low resolution of climate models hinder rapid progress. Thus, projection of Southern Ocean warming will likely remain uncertain, but recent community effort has laid a solid foundation for substantial progress.

Effects of chlorination on microplastics pollution: Physicochemical transformation and chromium adsorption.

The large number of microplastics (MPs) that appear in the environment has drawn much attention. Few studies, however, have examined the transformation of MPs in water treatment processes and their effects on environmental pollutants. In this study, the alteration of the physicochemical characteristics of polyethylene and thermoplastic polyurethane upon chlorination, as well as the influence of this alteration on contaminants, were investigated. The findings indicated that microplastics underwent significant morphology and O-functional groups changes during chlorination. It is noteworthy that the mechanisms controlling the chlorination treatment of the two MPs are clearly different. The results of aggregation and adsorption experiments showed that the chlorination treatment enhanced the aggregation ability of the MPs in brine and their interaction with Cr(VI). The present discoveries further suggested that water treatment could alter the migration capacity of microplastics and the distribution of contaminants in the aqueous environment by altering the adsorption of microplastics to the contaminants.

Thermal coupling of the Indo-Pacific warm pool and Southern Ocean over the past 30,000 years.

The role of the tropical Pacific Ocean and its linkages to the southern hemisphere during the last deglacial warming remain highly controversial. Here we explore the evolution of Pacific horizontal and vertical thermal gradients over the past 30 kyr by compiling 340 sea surface and 7 subsurface temperature records, as well as one new ocean heat content record. Our records reveal that La Niña-like conditions dominated during the deglaciation as a result of the more intense warming in the western Pacific warm pool. Both the subsurface temperature and ocean heat content in the warm pool rose earlier than the sea surface temperature, and in phase with South Pacific subsurface temperature and orbital precession, implying that heat exchange between the tropical upper water column and the extratropical Southern Ocean facilitated faster warming in the western Pacific. Our study underscores the key role of the thermal coupling between the warm pool and the Southern Ocean and its relevance for future global warming.

The impact of chlorination on the tetracycline sorption behavior of microplastics in aqueous solution.

Considering the large volumes of treated water and incomplete elimination of pollutants, wastewater treatment plants (WWTPs) remain a considerable source of microplastics (MPs). Chlorine, the most frequently used disinfectant in WWTPs, has a strong oxidizing impact on MPs. However, little is documented, to date, about the impact of chlorination on the transformation of MPs and the subsequent environmental behaviors of the chlorinated MPs when released into the aquatic environment. This study explored the response of the physicochemical properties of specific thermoplastics, namely polyurethane (TPU) MPs and polystyrene (PS) MPs, to chlorination and their emerging pollutant [tetracycline (TC)] adsorption behavior in aqueous solution. The results indicated that the O/C ratio of the MP surface did not significantly change, and that there were increases in the O-containing functional groups of the TPU and PS MPs, after chlorination. The surface area of the chlorinated TPU MPs increased by 45 %, and that of the chlorinated PS increased by 21 %, compared with the pristine ones, which contributed to the TC adsorption. The adsorption isotherm fitting parameters suggested that the chlorinated TPU fitted the multilayer adsorption, and the chlorinated PS was inclined to the monolayer adsorption. The relative abundance of the O-containing functional groups, on the TPU surface, led to the release of CHCl3 molecules, and the clear surface irregularities and fissures occurred after chlorine treatment. No fissures were found on the surface of the chlorinated PS MPs. The hydrophobicity and electrostatic adsorption were proved to be the major impacts on the TC adsorption of the chlorinated MPs, and the subsequently formed hydrogen bonds led to the stronger adsorption capacity of the chlorinated TPU than the chlorinated PS MPs.

The effects of polypropylene microplastics on the DBP formation under the chlorination and chloramination processes.

With the increased use of microplastics in modern society, tonnes of various microplastics (MPs) end up in natural and engineered water systems if not properly handled. Being a class of organics, the role of MPs during the disinfection of water treatment systems is still unclear at this stage. In the current experimental study, the formation of 6 typical disinfection by-products (DBPs) was investigated using varying concentrations of polypropylene (PP) MPs under various aquatic chemistry conditions and disinfectants. All investigated DBPs were detected, during the chlorination of PP, with an average CHCl3 concentration of 378 µg/g, and other DBPs, including CHCl2Br, TCA, DCAN, 1,1-DCP, and TCNM, were present in less than 60 µg/g, on average. When PP coexisted with Suwannee River Fulvic acid (SRFA), a suppression of DBP formation was observed with a 56% net reduction compared with a condition of PP alone. The dynamic balance of being a DBP precursor, or a scavenger, by absorbing the organics of PP is subjected to aquatic chemistry. Increasing the pH decreases the HOCl concentrations, reducing the PP oxidation capacity and DBP formation. As salinity increases, the aggregation of PP can reduce the reaction sites on the surface of PP and enhance the adsorption of SRFA, hence lowering the formation of DBPs.

Effects of microplastics on DBPs formation under the chlorination of natural organic matters.

Microplastics have attracted extensive attention and concern because they inflict damage on human beings and the environment. When the microplastics enter the water system, they inevitably flow into the water treatment system and encounter disinfectants during the disinfection procedure. Chlorine can react with microplastics to form different kinds of disinfection byproducts (DBPs). O-containing functional groups on the surface of microplastics may play a major role in DBP formation. Without O-containing functional groups, microplastics can also form DBPs but with totally different mechanisms. Reactive oxygen species (ROS, i.e., •OH) and reactive chlorine substances (RCS, i.e., Cl• and ClO•) may attack the microplastics and form DBP precursors. With relatively low surface area and very little pore volume, microplastics cannot affect the DBP formation between Suwannee River fulvic acid (SRFA) and chlorine. When SRFA exists, microplastics with few O-containing functional groups can hardly form DBPs because of the inhibition of ROS and RCS.

Characteristics of subsurface chlorophyll maxima during the boreal summer in the South China Sea with respect to environmental properties.

Characterizing the vertical distribution of chlorophyll a in the water column in each oceanic region is crucial for accurate assessment of depth-integrated phytoplankton biomass. In this study, the characteristics of the subsurface chlorophyll maximum (SCM) in the South China Sea (SCS) during the boreal summer were investigated by using bio-optical and hydrological data collected during four cruises from 2008 to 2015. During the boreal summer, a well-developed SCM layer was found to be a prominent feature in the SCS, with the thickness, depth, and magnitude of the SCM exhibiting large spatial variability. The vertical position of the SCM varied between 11 and 99 m, with an average value of 53 m. Light attenuation played a fundamental role in determining the depth (ZSCM) and magnitude of the SCM (Chlmax), as reflected by their relationships with the euphotic zone depth (Zeu). However, because significant positive correlations were found between ZSCM and the depth of potential density at 23 kg m-3 (Zσ=23), physical processes were inferred to be more important in modulating the fluctuation of ZSCM, especially in open-ocean areas. Anticyclonic eddies, which act to deepen the nutricline by means of isopyncnal displacement, may play a role in aggravating nutrient limitation in the SCM layer, which leads to deepening of ZSCM, weakening of Chlmax, and a fall in the total integrated chlorophyll a within the euphotic layer (ChlintZeu). Knowledge of ocean physical conditions and the variability of ZSCM should be taken into consideration to improve the accuracy of ChlintZeu estimates based on the surface chlorophyll a concentration (Chlsurf), especially when Chlsurf is very low. Our assessment of SCM parameters provides the basis for a better understanding and quantification of their role in primary production estimation within the SCS.

Community differentiation of bacterioplankton in the epipelagic layer in the South China Sea.

The South China Sea (SCS) is the largest marginal sea in the western tropical Pacific Ocean and is characterized by complex physicochemical environments. To date, the biogeographic patterns of the microbial communities have rarely been reported at a basin scale in the SCS. In this study, the bacterial assemblages inhabiting the epipelagic zone across 110°E to 119°E along 14°N latitude were uncovered. The vertical stratification of both bacterial taxa and their potential functions were revealed. These results suggest that the water depth-specific environment is a driver of the vertical bacterioplankton distribution. Moreover, the bacterial communities were different between the eastern stations and the western stations, where the environmental conditions were distinct. However, the mesoscale eddy did not show an obvious effect on the bacterial community due to the large distance between the sampling site and the center of the eddy. In addition to the water depth and longitudinal location of the samples, the heterogeneity of the phosphate and salinity concentrations also significantly contributed to the variance in the epipelagic bacterial community in the SCS. To the best of our knowledge, this study is the first to report that the variability in epipelagic bacterioplankton is driven by the physicochemical environment at the basin scale in the SCS. Our results emphasize that the ecological significance of bacterioplankton can be better understood by considering the relationship between the biogeographic distribution of bacteria and the oceanic dynamics processes.