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1.
J Perinat Med ; 50(8): 1030-1035, 2022 Oct 26.
Artículo en Inglés | MEDLINE | ID: mdl-35570568

RESUMEN

OBJECTIVES: To determine the racial and ethnic compositions of the participants in obstetric randomized controlled trials (RCTs) and compare them to the US general population. METHODS: RCTs published in two premier US journals, American Journal of Obstetrics and Gynecology, Obstetrics and Gynecology from January 2010 to April 2020 were analyzed. The racial and ethnic distributions of the study participants were extracted and expressed as percentages for each article. Obstetrics articles were selected and then further divided into subcategories. Statistical analyses were performed on racial and ethnicity representation in each subcategory compared to a US population norm. RESULTS: Overall, a wide variation of racial and ethnic distribution was noted among studies. However, statistically significant overrepresentation of Non-Hispanic Black population and underrepresentation of White and Asian races were noted while Hispanic population's representation was comparable to the US general population. This observation was persistent across most of the subcategories. CONCLUSIONS: RCTs in the field of Obstetrics showed an overrepresentation of Black population. This observation was unique when we consider the previous reports in other fields of medicine. These findings should be taken into consideration when interpreting the results of RCTs conducted in US.


Asunto(s)
Etnicidad , Obstetricia , Femenino , Humanos , Embarazo , Grupos Raciales , Ensayos Clínicos Controlados Aleatorios como Asunto , Estudios Retrospectivos , Estados Unidos
2.
Am J Obstet Gynecol ; 225(6): B9-B18, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-34537158

RESUMEN

With the recent advances in gene editing with systems such as CRISPR-Cas9, precise genome editing in utero is on the horizon. Sickle cell disease is an excellent candidate for in utero fetal gene therapy, because the disease is monogenic, causes irreversible harm, and has life-limiting morbidity. Gene therapy has recently been proven to be effective in an adolescent patient. Several hurdles still impede the progress for fetal gene therapy in humans, including an incomplete understanding of the fetal immune system, unclear maternal immune responses to in utero gene therapy, risks of off-target effects from gene editing, gestational age constraints, and ethical questions surrounding fetal genetic intervention. However, none of these barriers appears insurmountable, and the journey to in utero gene therapy for sickle cell disease and other conditions should be well underway.


Asunto(s)
Anemia de Células Falciformes/terapia , Edición Génica , Anemia de Células Falciformes/embriología , Femenino , Terapia Genética , Humanos , Obstetricia , Perinatología , Guías de Práctica Clínica como Asunto , Embarazo , Atención Prenatal , Sociedades Médicas
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