Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 27
Filtrar
1.
J Cardiovasc Surg (Torino) ; 52(6): 829-39, 2011 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-22051991

RESUMEN

Despite many randomised controlled trials there are none that recommend carotid artery stenting (CAS) replaces carotid endarterectomy (CEA) for preventing stroke in patients with atherosclerotic carotid artery stenosis. CAS continues to be attractive due to its minimally-invasive nature and potential benefit in those patients at 'high risk' during open surgery. The belief that CAS will replace CEA is likely misplaced; a complimentary role for each mode of treatment is a more realistic vision for the future. Assessment of the existing data may provide useful information as to the subgroups that have most to benefit from each treatment type, therefore allowing a patient-specific approach to the management of individual lesions. This knowledge, coupled with further advances in the techniques of open and endovascular surgery, will progress the application of CAS and better its results.


Asunto(s)
Angioplastia/instrumentación , Enfermedades de las Arterias Carótidas/terapia , Endarterectomía Carotidea , Stents , Angioplastia/efectos adversos , Enfermedades de las Arterias Carótidas/cirugía , Endarterectomía Carotidea/efectos adversos , Medicina Basada en la Evidencia , Humanos , Selección de Paciente , Diseño de Prótesis , Ensayos Clínicos Controlados Aleatorios como Asunto , Sistema de Registros , Medición de Riesgo , Factores de Riesgo , Resultado del Tratamiento
2.
Eur J Vasc Endovasc Surg ; 42(3): 340-6, 2011 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-21628100

RESUMEN

INTRODUCTION: Splanchnic and renal artery aneurysms (SRAAs) are uncommon but potentially life-threatening in case of rupture. Whether these aneurysms are best treated by open repair or endovascular intervention is unknown. The aim of this retrospective study is to report the results of open and endovascular repairs in two European institutions over a fifteen-year period. We have reviewed the available literature published over the 10 last years. METHODS: All patients with SRAAs diagnosed from 1995 to 2010 in St Marys Hospital (London, UK) and Henri Mondor Hospital (Créteil, France) were reviewed. Preoperative clinical and anatomical data, operative management and outcomes were recorded from the charts and analyzed. RESULTS: 40 patients with 51 SRAAs were identified. There were 21 males and 19 females with a mean age of 57 ± 14.9 years. The aneurysms locations were: 14 (27%) renal, 11 (22%) splenic, 7 (14%) celiac trunk, 7 (14%) superior mesenteric artery, 4 (8%) hepatic, 4 (8%) pancreaticoduodenal arcades, 3 (6%) left gastric and 1 (2%) gastroduodenal. 4 patients presented with a ruptured SRAA. 17 SRAAs in 16 patients were treated by open repair, 15 in 15 patients were treated endoluminally and 17 (mean diameter: 18 mm, range: 8-75 mm) were managed conservatively. One patient with metastatic pulmonary cancer with two mycotic aneurysms of the superior mesenteric artery (75 mm) and celiac trunk (15 mm) was palliated. After endovascular treatment, the immediate technical success rate was 100%. There was no significant difference between open repair and endovascular patients in terms of 30-day post-operative mortality rate and peri-operative complications. No in-hospital death occurred in patients treated electively. Postoperatively, four patients (1 ruptured and 3 elective) suffered non-lethal mild to severe complication in the open repair group, as compared with one in the endovascular group (p = .34). The mean length of stay was significantly higher after open repair as compared with endovascular repair (17 days, range: 8-56 days vs. 4 days, range: 2-6; p < .001). The mean follow-up time was 17.8 months (range: 0-143 months) after open repair, 15.8 months (range: 0-121 months) after endovascular treatment, and 24.8 (range: 3-64 months) for patient being managed conservatively. No late death related to the VAA occurred. In each group, 2 successful reoperations were deemed necessary. In the endovascular group, two patients presented a reperfusion of the aneurysmal sac at 6 and 24 months respectively. CONCLUSION: No significant difference in term of 30-day mortality and post-operative complication rates could be identified between open repair and endovascular treatment in the present series. Endovascular treatment is a safe alternative to open repair but patients are exposed to the risk of aneurysmal reperfusion. This mandates careful long-term imaging follow up in patients treated endoluminally.


Asunto(s)
Aneurisma/cirugía , Arteria Renal , Circulación Esplácnica , Adulto , Anciano , Implantación de Prótesis Vascular , Procedimientos Endovasculares , Femenino , Francia , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Reino Unido
3.
J Cardiovasc Surg (Torino) ; 52(3): 353-62, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21577190

RESUMEN

In recent years, steerable catheter systems have been introduced into clinical practice for cardiac mapping and ablation procedures. As endovascular therapy is becoming more complex, more advanced and versatile catheter designs utilizing robotic technology may have a role in aortic and peripheral arterial interventions. This article discusses alternative steerable catheter designs focusing on robotic endovascular catheter technology. A comprehensive comparison, review and analysis of robotic versus manual techniques in the visceral segment are presented to reveal both their advantages and limitations. Preclinical studies and early experience suggest that robotically steerable endovascular catheters offer improved manoeuvrability at the catheter tip, enhanced positional control and "off-the-wall" centreline navigation in a remote-control fashion. These advanced systems have the potential to overcome some of the technical difficulties with manual catheter control, improve stability at key target areas, reduce the risk of vessel trauma, distal embolization and radiation exposure, whilst improving overall operator performance with short learning curves. Robotic catheter technology may be more suitable to complex and often unpredictable anatomy in the visceral segment and may offer a reliable platform for future applications involving device delivery or target intervention. This intuitive technology is rapidly evolving and still requires technological refinements to extend current capabilities. Clinical studies involving head-to-head comparisons with conventional techniques are essential for evaluating its long-term safety and efficacy.


Asunto(s)
Aorta , Cateterismo Periférico/instrumentación , Catéteres , Procedimientos Endovasculares/instrumentación , Robótica , Terapia Asistida por Computador/instrumentación , Vísceras/irrigación sanguínea , Arterias , Cateterismo Periférico/efectos adversos , Catéteres/efectos adversos , Procedimientos Endovasculares/efectos adversos , Diseño de Equipo , Humanos , Radiografía Intervencional/instrumentación , Medición de Riesgo , Factores de Riesgo
4.
Eur J Vasc Endovasc Surg ; 42(4): 531-8, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21388839

RESUMEN

INTRODUCTION: Advanced endovascular procedures require a high degree of skill with a long learning curve. We aimed to identify differential increases in endovascular skill acquisition in novices using conventional (CC), manually steerable (MSC) and robotic endovascular catheters (RC). MATERIALS/METHODS: 10 novices cannulated all vessels within a CT-reconstructed pulsatile-flow arch phantom in the Simulated Endovascular Suite. Subjects were randomly assigned to conventional/manually-steerable/robotic techniques as the first procedure undertaken. The operators repeated the task weekly for 5 weeks. Quantitative (cannulation times, wire/catheter-tip movements, vessel wall hits) and qualitative metrics (validated rating scale (IC3ST)) were compared. RESULTS: Subjects exhibited statistically significant differences when comparing initial to final performance for total procedure times and catheter-tip movements with all catheter types. Sequential non-parametric comparisons identified learning curve plateau levels at weeks 2 or 3(RCs, MSCs), and at week 4(CCs) for the majority of metrics. There were significantly fewer catheter-tip movements using advanced catheter technology after training (Week 5: CC 74 IQR(59-89) versus MSC 62(44-81); p = 0.028, and RC 33 (28-44); p = 0.012). RCs virtually eliminated wall hits at the arch (CC 29(28-76) versus RC 8(6-9); p = 0.005) and produced significantly higher overall performance scores (p < 0.02). CONCLUSION: Advanced endovascular catheters, although more intricate, do not seem to take longer to master and in some areas offer clear advantages with regards to positional control, at a faster rate. RCs seem to be the most intuitive and advanced skill acquisition occurs with minimal training. Robotic endovascular technology may have a significantly shorter path to proficiency allowing an increased number of trainees to attempt more complex endovascular procedures earlier and with a greater degree of safety.


Asunto(s)
Cateterismo , Procedimientos Endovasculares/educación , Curva de Aprendizaje , Robótica , Catéteres , Simulación por Computador , Diseño de Equipo , Humanos
5.
Eur J Vasc Endovasc Surg ; 41(6): 795-802, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21320788

RESUMEN

OBJECTIVES: To investigate failures in patient safety for patients undergoing vascular and endovascular procedures to guide future quality and safety interventions. DESIGN: Single centre prospective observational study. METHODS: 66 procedures (17 thoracoabdominal and 23 abdominal aortic aneurysms, 4 carotid and 22 limb procedures) were observed prospectively over a 9-month period (251 h operating time) by two trained observers. Event logs were recorded for each procedure. Two blinded experts identified and independently categorised failures into 22 types (using a validated category tool) and severity (5-point scale). Data are expressed as median (range). Statistical analysis was performed using Mann-Whitney U, Kruskal-Wallis and Spearman's Rank tests. RESULTS: 1145 failures were identified with good inter-assessor reliability (Cronbach's alpha 0.844). The commonest failure types related to equipment (including unavailability, configuration and other failures) (269/1145 [23.5%]) and communication (240/1145 [21.0%]). A comparatively lower number of technical and psychomotor failures were identified (103 [9.0%]). The number of failures correlated with procedure duration (rho = 0.695, p < 0.001) but not anatomical site of the procedure or pathology of the disease process. Failure rate was higher in patients undergoing combined surgical/endovascular procedures compared to open surgery (median 5.7/h [IQR 4.2-8.1] vs 3.0/h [2.5-3.5]; p < 0.001). The severity of failures was similar (1.5/5 [1-2] vs 1/5 [1-2] respectively; p = 0.095). For combined procedures, failure rates were significantly higher during the endovascular phase (9.6/h [7.5-13.7]) compared to the non-endovascular phase (3.0/h [1.0-5.0]; p < 0.001). CONCLUSIONS: Failures in patient safety are common during complex arterial procedures. Few failures were severe, although minor failures during critical stages and accumulation of multiple minor failures may potentially be important. Failures occurred especially during the endovascular phase and were often related to equipment or communication aspects. Interventions to improve procedural safety and quality of care should primarily target these specific areas.


Asunto(s)
Aneurisma de la Aorta/cirugía , Enfermedades de las Arterias Carótidas/cirugía , Errores Médicos/estadística & datos numéricos , Enfermedad Arterial Periférica/cirugía , Mejoramiento de la Calidad , Procedimientos Quirúrgicos Vasculares/efectos adversos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Falla de Equipo/estadística & datos numéricos , Humanos , Errores Médicos/prevención & control , Persona de Mediana Edad , Estudios Prospectivos , Insuficiencia del Tratamiento , Adulto Joven
6.
J Cardiovasc Surg (Torino) ; 52(1): 17-37, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21224807

RESUMEN

Reduced training times, increasing complexity of endovascular and open vascular interventions and concerns for patient's safety have necessitated a modernisation in surgical training. A more strategic approach is required to facilitate the acquisition of surgical skills outside the operating room and to minimize the risks to patients as surgeons develop their technical expertise. Virtual reality simulation has been proposed as a means to train and objectively assess technical endovascular performance without risks to patient safety. This article reviews the evidence and the limitations for this adjunctive tool, the implementation in current training programmes and future applications to maintain the highest standards of care for treatment of vascular disease.


Asunto(s)
Simulación por Computador , Instrucción por Computador , Educación de Postgrado en Medicina/métodos , Procedimientos Endovasculares/educación , Internado y Residencia , Quirófanos , Procedimientos Quirúrgicos Vasculares/educación , Competencia Clínica , Gráficos por Computador , Curriculum , Humanos , Modelos Cardiovasculares , Modelos Educacionales
7.
Eur J Vasc Endovasc Surg ; 41(4): 488-91, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21232994

RESUMEN

This report describes endovascular stenting of an acute mycotic ascending aortic aneurysm. An eighty-three year old lady presented nine weeks after aortic valve surgery and subsequent thyroidectomy with sternal pain secondary to a mycotic ascending aortic pseudoaneurysm. The pseudoaneurysm was visible through the unhealed sternum. Open repair was considered too high a mortality risk. Endovascular stenting was performed using two covered infrarenal proximal extension devices (GORE Excluder Aortic Extender(®), W. L. Gore & Associates, Flagstaff, Arizona, USA) deployed from a right axillary approach utilising overdrive cardiac pacing. Post procedure imaging revealed shrinkage of the pseudoaneurysm sac.


Asunto(s)
Aneurisma Falso/cirugía , Aneurisma Infectado/cirugía , Aneurisma de la Aorta/cirugía , Implantación de Prótesis Vascular , Procedimientos Endovasculares , Enfermedad Aguda , Anciano de 80 o más Años , Aneurisma Falso/diagnóstico por imagen , Aneurisma Falso/microbiología , Aneurisma Infectado/diagnóstico por imagen , Aneurisma Infectado/microbiología , Angiografía de Substracción Digital , Antibacterianos/uso terapéutico , Aneurisma de la Aorta/diagnóstico por imagen , Aneurisma de la Aorta/microbiología , Válvula Aórtica/cirugía , Aortografía/métodos , Prótesis Vascular , Implantación de Prótesis Vascular/instrumentación , Estimulación Cardíaca Artificial , Procedimientos Endovasculares/instrumentación , Femenino , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Humanos , Diseño de Prótesis , Staphylococcus aureus/aislamiento & purificación , Stents , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
8.
Int J Surg ; 9(2): 177-82, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21081185

RESUMEN

AIM: Microembolization continues to be a major risk for patients undergoing carotid artery stenting (CAS) of high-grade atherosclerotic carotid stenoses. Further insight into the characteristics and significance of these embolized particles was deemed necessary. We aimed to assess the size and composition of debris captured by filters during CAS and to determine if this could be predicted using standard imaging techniques. METHODS: 20 patients (10 symptomatic, 15 men, mean age 64.6 years) undergoing CAS for high-grade ICA stenosis were recruited. All underwent pre-operative CT angiography and calcium scoring. All underwent CAS using the same protocol. A filter-type embolic protection device (EPD) was used and retrieved post-operatively and captured particles underwent analysis using a Scanning Electron Microscope (SEM) for counting, sizing, and composition. RESULTS: Clinical. Debris was found on 100% of filters when analysed with SEM. There were non-significant trends for CAS in asymptomatic patients to produce a greater number of smaller, calcified particles while in symptomatic patients we observed larger, lipid-rich particles. When stratified according to pre-operative calcium scores, 'calcium-rich' plaques produced significantly greater numbers of emboli captured on the EPD (p = 0.02). CONCLUSIONS: Filter-type EPDs collect debris of significant quantity and size during the CAS procedure as performed in our institution. The collected material was likely dislocated from the atherosclerotic plaque. CT calcium scoring allows us to predict the nature of material captured by the EPD. These data may allow the clinician to individualise care during CAS and thus reduce peri-operative risk.


Asunto(s)
Angioplastia/efectos adversos , Arterias Carótidas , Estenosis Carotídea/cirugía , Dispositivos de Protección Embólica , Embolia/etiología , Embolia/prevención & control , Stents/efectos adversos , Anciano , Anciano de 80 o más Años , Calcio/análisis , Estenosis Carotídea/diagnóstico , Embolia/diagnóstico , Femenino , Humanos , Masculino , Microscopía Electrónica de Rastreo , Persona de Mediana Edad , Tomografía Computarizada Espiral , Tomografía Computarizada por Rayos X
10.
Eur J Vasc Endovasc Surg ; 40(6): 715-21, 2010 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-20920861

RESUMEN

OBJECTIVE: To evaluate the outcome of hybrid treatment of the aortic arch with supra-aortic debranching and endovascular stent-graft repair in a selected group of patients with complex disease. DESIGN: Case series study with retrospective analysis of prospectively collected non-randomised data. METHODS: Patients with hybrid repair of complex arch disease at a single centre over a 6-year period were enrolled in the study. Only patients with extensive arch pathologies requiring debranching of at least the left carotid artery were considered. Patients were divided into those who underwent complete and partial supra-aortic revascularisation. The χ2 test was used to evaluate differences in outcomes. Logistic regression analyses were applied to identify predictors of poor outcome. RESULTS: A total of 33 patients were included in the study. Complete and partial arch repair was performed in nine and 24 patients, respectively. The aortic disease extended to the thoracic and abdominal aorta in 39% and 52% of the patients, respectively. One-third of the patients (30%) were treated on an urgent/emergency basis. Elective 30-day mortality and morbidity rates were 13% and 35%, respectively. Early mortality was significantly higher in the complete arch repair group (p=0.046). Pre-existing renal impairment was identified as a poor prognostic factor. All extra-anatomic bypasses remained patent and no aortic disease-related deaths occurred during a mean follow-up period of 23 months (range, 1.5-58 months). Complete arch repair was associated with an increased incidence of late endoleak (p=0.018). CONCLUSIONS: Hybrid treatment of the aortic arch provides a feasible alternative treatment in patients who are high risk for conventional open surgical repair. Careful selection of patients is required to achieve satisfactory results.


Asunto(s)
Aorta Abdominal/cirugía , Aorta Torácica/cirugía , Enfermedades de la Aorta/cirugía , Implantación de Prótesis Vascular , Procedimientos Endovasculares , Adulto , Anciano , Anciano de 80 o más Años , Aorta Abdominal/diagnóstico por imagen , Aorta Torácica/diagnóstico por imagen , Enfermedades de la Aorta/diagnóstico por imagen , Enfermedades de la Aorta/mortalidad , Aortografía/métodos , Prótesis Vascular , Implantación de Prótesis Vascular/efectos adversos , Implantación de Prótesis Vascular/instrumentación , Implantación de Prótesis Vascular/mortalidad , Distribución de Chi-Cuadrado , Endofuga/etiología , Procedimientos Endovasculares/efectos adversos , Procedimientos Endovasculares/instrumentación , Procedimientos Endovasculares/mortalidad , Femenino , Humanos , Modelos Logísticos , Londres , Masculino , Persona de Mediana Edad , Selección de Paciente , Diseño de Prótesis , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Stents , Factores de Tiempo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
11.
Surgeon ; 8(1): 28-38, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-20222400

RESUMEN

Thoraco-abdominal aortic aneurysm repair remains a formidable challenge to vascular surgeons. The traditional repair of thoraco-laparotomy with aortic cross-clamping is associated with a high morbidity and mortality despite significant advances in perioperative critical care, anaesthetic and surgical techniques. The advent of the endovascular revolution has shown a marked paradigm in the approach to all aneurysm repairs. As a logical progression from the open repair, the St Mary's visceral hybrid repair combines traditional open techniques (retrograde visceral and renal revascularisation via mid-line laparotomy) with endovascular stent grafting, thereby avoiding the need for thoracotomy and aortic cross-clamping. In specialist centres, the results have been encouraging and easily comparable to the open repair. The technique has been used in several centres around the world and represents a robust, transferrable method of repairing thoraco-abdominal aortic aneurysms. Stent-grafting technologies have reached a point of sophistication that wholly endovascular methods of repairing thoraco-abdominal aortic aneurysms are being performed in several centres around the world. Although these stent grafts have to be customised to the individual patient and are only suitable for certain types of aneurysmal anatomies, they represent the future of thoraco-abdominal aortic aneurysm repair. We review the history of thoraco-abdominal aortic aneurysm repair, the exciting advances in their treatment and discuss our approach to the management of thoraco-abdominal aortic aneurysms in the 21st century.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Laparotomía/tendencias , Procedimientos Quirúrgicos Torácicos/tendencias , Procedimientos Quirúrgicos Vasculares/métodos , Humanos , Procedimientos Quirúrgicos Vasculares/tendencias
12.
Eur J Vasc Endovasc Surg ; 38(5): 578-85, 2009 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-19666233

RESUMEN

OBJECTIVE: To report the collaborative data of 3 major European Vascular Units using the 'visceral hybrid' procedure for thoraco-abdominal aortic aneurysms and dissections. METHODS: A consecutive series of 107 urgent and elective high-risk patients were included in a prospectively collected database. RESULTS: All stents involved the entire thoracic and abdominal aorta with left subclavian coverage in 19 and revascularisation in 12. The distal landing zone was in the infra-renal aorta in 75% and in the iliac artery in 25%. The 30-day mortality rate was 16/107 (14.95%). 13/107 (12.1%) of the patients suffered spinal cord ischaemia which was complete and permanent in 9/12 (8.4%). 4 patients (3.7%) required long term dialysis and a segment of gut infarction requiring resection occurred in 3 (2.8%). Most patients had visceral bypass grafting and aortic stent-grafting performed in one stage. In 18 patients the stenting was performed later. Three of these patients ruptured before the stenting procedure was undertaken. CONCLUSION: These early results of visceral hybrid repair for high-risk patients with complex thoraco-abdominal aortic aneurysms are encouraging, in a group of patients in whom fenestrated/branched stent-grafting is not an option and open surgery hazardous.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Implantación de Prótesis Vascular , Adulto , Anciano , Anciano de 80 o más Años , Aneurisma de la Aorta Torácica/complicaciones , Aneurisma de la Aorta Torácica/mortalidad , Aneurisma de la Aorta Torácica/fisiopatología , Prótesis Vascular , Implantación de Prótesis Vascular/efectos adversos , Implantación de Prótesis Vascular/instrumentación , Implantación de Prótesis Vascular/mortalidad , Conducta Cooperativa , Bases de Datos como Asunto , Femenino , Alemania , Mortalidad Hospitalaria , Humanos , Cooperación Internacional , Londres , Masculino , Persona de Mediana Edad , Paraplejía/etiología , Estudios Prospectivos , Falla de Prótesis , Insuficiencia Renal/etiología , Medición de Riesgo , Isquemia de la Médula Espinal/etiología , Stents , Accidente Cerebrovascular/etiología , Factores de Tiempo , Resultado del Tratamiento , Grado de Desobstrucción Vascular
13.
Eur J Vasc Endovasc Surg ; 37(5): 544-56, 2009 May.
Artículo en Inglés | MEDLINE | ID: mdl-19233691

RESUMEN

OBJECTIVES: There is lack of consensus regarding concurrent vs. staged approaches, and the prioritisation of staged procedures in cases presenting with colorectal carcinoma (CRC) and abdominal aortic aneurysm (AAA) synchronously. We aim to present our experience, review the literature on this therapeutic dilemma and examine the role of endovascular aortic repair (EVAR). DESIGN, MATERIALS AND METHODS: An observational study of the experience of two centres and a systematic review of the published literature. RESULTS: Twenty-four patients were identified from the prospective databases of two tertiary referral centres between 2001 and 2006. Intervention for both malignancy and aneurysm was performed in 13 patients. In 10 patients, cancer resection was performed initially and was followed by open aneurysm repair (n=3) or EVAR (n=7). Two patients (AAA diameters: 7.0 and 8.0cm) underwent EVAR prior to colonic resection. One patient was selected for synchronous surgery. There were no interval AAA ruptures, graft infection or postoperative mortalities. Literature review identified 269 such cases; of these 101 were treated by combined surgery. In staged surgery, there were nine interval aneurysmal ruptures and one aortic graft infection. CONCLUSIONS: In our experience, staged management can be undertaken, without interval aneurysmal rupture. EVAR has an evolving role in preventing delay in CRC management, in high-risk patients, and during combined intervention.


Asunto(s)
Aneurisma de la Aorta Abdominal/complicaciones , Neoplasias Colorrectales/complicaciones , Complicaciones Intraoperatorias/epidemiología , Complicaciones Posoperatorias/epidemiología , Anciano , Anciano de 80 o más Años , Aneurisma de la Aorta Abdominal/diagnóstico , Aneurisma de la Aorta Abdominal/cirugía , Rotura de la Aorta/epidemiología , Colectomía/métodos , Neoplasias Colorrectales/diagnóstico , Neoplasias Colorrectales/cirugía , Femenino , Estudios de Seguimiento , Humanos , Tiempo de Internación , Masculino , Persona de Mediana Edad , Morbilidad/tendencias , Estadificación de Neoplasias/métodos , Pronóstico , Estudios Prospectivos , Tasa de Supervivencia/tendencias , Tomografía Computarizada por Rayos X , Reino Unido/epidemiología , Procedimientos Quirúrgicos Vasculares/métodos
14.
Eur J Vasc Endovasc Surg ; 37(2): 175-81, 2009 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19046650

RESUMEN

OBJECTIVES: To describe our experience of treating juxtarenal (JRAAA's <4mm neck) and thoracoabdominal aortic aneurysms (TAAA's) using fenestrated and branched stent graft technology. DESIGN: Prospective single centre experience. METHODS: Since 2005, 29 fenestrated/branched procedures have been performed. 15 patients are studied with JRAAAs (n=7; median neck length 0mm (IQR 0-3.8)) or TAAAs (type I (n=2), III (n=2), IV (n=4)). ASA grade III in 12/15. Maximum diameter of aneurysm 64 mm (56-74 mm). Aneurysms were excluded using covered stents or branches from the main body to patent visceral vessels (40 target vessels total). Pre-operative and follow-up CT scans (1, 3, and 12 months) were analysed by a single Vascular Interventional Radiologist. RESULTS: Technical success for cannulation and stenting of target vessels was 98%. In-hospital mortality was 0%. One patient underwent conversion to open repair. Five had major complications including one paraplegia (type III TAAA) with subsequent recovery. Median length of stay was 9 days (IQR 7-18.75). At a median follow-up of 12 months (9-14), CT confirmed 36/37 (97%) target vessels remain patent. Sac size increased >5 mm in one patient only. There were no type I endoleaks, three type II endoleaks (one embolised, two under surveillance) and three type III endoleaks (two successfully treated percutaneously, one aneurysm ruptured 18 months after endografting and died). CONCLUSION: In selected patients, fenestrated and branched stents appear to be a safe and effective alternative to surgery for juxtarenal and thoracoabdominal aneurysms. The complication and mortality rates are low. The long-term durability of this procedure, however, needs to be proven.


Asunto(s)
Aneurisma de la Aorta Abdominal/cirugía , Aneurisma de la Aorta Torácica/cirugía , Implantación de Prótesis Vascular/instrumentación , Prótesis Vascular , Stents , Anciano , Aneurisma de la Aorta Abdominal/diagnóstico por imagen , Aneurisma de la Aorta Abdominal/mortalidad , Aneurisma de la Aorta Torácica/diagnóstico por imagen , Aneurisma de la Aorta Torácica/mortalidad , Rotura de la Aorta/etiología , Rotura de la Aorta/cirugía , Aortografía/métodos , Implantación de Prótesis Vascular/efectos adversos , Implantación de Prótesis Vascular/mortalidad , Bases de Datos como Asunto , Femenino , Humanos , Tiempo de Internación , Masculino , Paraplejía/etiología , Estudios Prospectivos , Diseño de Prótesis , Falla de Prótesis , Reoperación , Factores de Tiempo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
15.
Eur J Vasc Endovasc Surg ; 35(2): 145-52, 2008 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17964194

RESUMEN

OBJECTIVES: Post-operative haemorrhage is a recognised complication and independent predictor of outcome in complex vascular surgery. The off-license administration of activated Recombinant Factor VII (rFVIIa) to treat haemorrhage in other surgical settings has been investigated, but concerns over potential adverse events have limited its use in vascular surgery. This article reports rFVIIa's method of action and systematically reviews rFVIIa's role in complex vascular surgery. METHODS: A systematic literature search identified articles reporting on rFVIIa administration within vascular surgery patients. Patient-specific data regarding transfusion requirements was extracted and pooled statistical analysis performed. RESULTS: 15 articles reporting 43 patients were identified. RFVIIa has been administered in open and endovascular procedures and in both elective and emergency settings. Major aortic surgery accounted for 75% of cases. The range of rFVIIa administered as a cumulative dose was large, as was the variation in initial dose. Transfusion data from 9 patients was pooled and analysed. Significant differences were found between pre- and post- rFVIIa for packed red cell transfusions (mean 29.2 vs. 8.2, p=0.015). Intra-arterial thrombosis was reported in 3 cases. CONCLUSIONS: RFVIIa may reduce haemorrhage in selected vascular surgical patients. Randomized controlled trials are justified to definitively investigate its role within this setting.


Asunto(s)
Coagulantes/uso terapéutico , Factor VIIa/uso terapéutico , Hemorragia Posoperatoria/prevención & control , Procedimientos Quirúrgicos Vasculares/efectos adversos , Adulto , Anciano , Anciano de 80 o más Años , Coagulantes/administración & dosificación , Coagulantes/efectos adversos , Esquema de Medicación , Transfusión de Eritrocitos , Factor VIIa/administración & dosificación , Factor VIIa/efectos adversos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Hemorragia Posoperatoria/etiología , Hemorragia Posoperatoria/mortalidad , Proteínas Recombinantes/administración & dosificación , Proteínas Recombinantes/efectos adversos , Proteínas Recombinantes/uso terapéutico , Proyectos de Investigación , Trombosis/inducido químicamente , Resultado del Tratamiento
16.
Eur J Vasc Endovasc Surg ; 34(5): 552-60, 2007 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-17719806

RESUMEN

AIM: This comparative study attempts to evaluate the profile of S-100beta and Neuron-Specific Enolase (NSE), biomarkers of brain injury, in patients undergoing carotid endarterectomy (CEA) and carotid artery stenting (CAS) and to correlate this with haemodynamic and embolic events detected using trans-cranial Doppler (TCD). METHODS: 52 patients with internal carotid artery stenosis requiring intervention were recruited. 24 patients underwent CAS, and 28 underwent CEA. TCD was performed peri-operatively to record mean Middle Cerebral Artery (MCA) velocity and number of High Intensity Transient Signals (HITS) in the MCA of the operated side. Serum was drawn pre-operatively and at six time points in a 48 hour post-operative period, and then assayed using automated commercial equipment. Within and between group variability in markers were assessed by Generalized Estimation Equations modelling. RESULTS: CAS caused more HITS (p=0.028) but less haemodynamic disturbance (p=0.0001) than CEA. Treatment modality (CAS versus CEA) had no direct effect on S-100 changes (p=0.467). NSE levels declined after revascularisation in the CAS group but not after CEA (p=0.002). S-100beta levels rose in patients who had higher numbers of HITS (p=0.002). S-100beta and NSE were not associated with changes in MCA velocity (p>0.5). S-100beta alone increased significantly at 24 hours in those patients with a post-operative neurological deficit (p=0.015). CONCLUSIONS: Trans-cranial Doppler findings suggest that the mechanisms of rise in S-100beta and NSE levels may differ and may be due to increased peri-operative micro-embolisation and cerebral hypoperfusion respectively. Further studies are required to assess the clinical significance of these observed changes.


Asunto(s)
Angioplastia de Balón/efectos adversos , Isquemia Encefálica/etiología , Arteria Carótida Interna , Estenosis Carotídea/terapia , Endarterectomía Carotidea/efectos adversos , Factores de Crecimiento Nervioso/sangre , Fosfopiruvato Hidratasa/sangre , Proteínas S100/sangre , Anciano , Anciano de 80 o más Años , Velocidad del Flujo Sanguíneo , Isquemia Encefálica/diagnóstico , Estenosis Carotídea/diagnóstico por imagen , Estenosis Carotídea/cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Arteria Cerebral Media/diagnóstico por imagen , Arteria Cerebral Media/fisiopatología , Periodo Posoperatorio , Subunidad beta de la Proteína de Unión al Calcio S100 , Stents , Ultrasonografía Doppler Transcraneal
17.
Eur J Vasc Endovasc Surg ; 33(5): 525-32, 2007 May.
Artículo en Inglés | MEDLINE | ID: mdl-17291792

RESUMEN

INTRODUCTION: There is a learning curve in the acquisition of endovascular skills for the treatment of vascular disease. Integration of Virtual reality (VR) simulator based training into the educational training curriculum offers a potential solution to overcome this learning curve. However evidence-based training curricula that define which tasks, how often and in which order they should be performed have yet to be developed. The aim of this study was to determine the nature of skills acquisition on the renal and iliac modules of a commercially-available VR simulator. METHOD: 20 surgical trainees without endovascular experience were randomised to complete eight sessions on a VR iliac (group A) or renal (group B) training module. To determine skills transferability across the two procedures, all subjects performed two further VR cases of the other procedure. Performance was recorded by the simulator for parameters such as time taken, contrast fluid usage and stent placement accuracy. RESULTS: During training, both groups demonstrated statistically significant VR learning curves: group A for procedure time (p<0.001) and stent placement accuracy (p=0.013) group B for procedure time (p<0.001), fluoroscopy time (p=0.003) and volume of contrast fluid used (p<0.001). At crossover, subjects in group B (renal trained) performed to the same level of skill on the simulated iliac task as group A. However, those in group A (iliac trained) had a significantly higher fluoroscopy time (median 118 vs 72 secs, p=0.020) when performing their first simulated renal task than for group B. CONCLUSION: Novice endovascular surgeons can significantly improve their performance of simulated procedures through repeated practice on VR simulators. Skills transfer between tasks was demonstrated but complex task training, such as selective arterial cannulation in simulators and possibly in the real world appears to involve a separate skill. It is thus suggested that a stepwise and hierarchical training curriculum is developed for acquisition of endovascular skill using VR simulation to supplement training on patients.


Asunto(s)
Angioplastia de Balón , Competencia Clínica , Simulación por Computador , Angioplastia de Balón/educación , Constricción Patológica , Humanos , Arteria Ilíaca/patología , Radiografía Intervencional , Obstrucción de la Arteria Renal/terapia , Análisis y Desempeño de Tareas , Factores de Tiempo , Interfaz Usuario-Computador
18.
Eur J Vasc Endovasc Surg ; 33(4): 472-5, 2007 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-17161962

RESUMEN

Intimal hyperplasia develops preferentially in regions where the blood flow is stagnant and wall shear stress low. The small amplitude helical geometry of the SwirlGraft was designed to ensure physiological-type swirling flow, and thus suppress the triggers. We report the first conceptual testing of the SwirlGraft. Primary, assisted primary and secondary patency rates at 6 months in 20 patients were 57.9+/-11.4%, 84.4+/-8.3% and 100+/-0.0%. There was angiographic evidence of reduction of helical geometry in a proportion of the grafts. The helical graft is associated with high assisted primary and secondary patency. Elaboration of the surgical implantation techniques and an improved SwirlGraft design can be expected to exploit the advantages of the helical concept.


Asunto(s)
Brazo/irrigación sanguínea , Derivación Arteriovenosa Quirúrgica/instrumentación , Implantación de Prótesis Vascular/instrumentación , Politetrafluoroetileno , Diálisis Renal/métodos , Adulto , Anciano , Anciano de 80 o más Años , Angiografía , Derivación Arteriovenosa Quirúrgica/efectos adversos , Implantación de Prótesis Vascular/efectos adversos , Constricción Patológica/etiología , Europa (Continente) , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Estudios Prospectivos , Diseño de Prótesis , Flujo Sanguíneo Regional , Trombosis/etiología , Factores de Tiempo , Resultado del Tratamiento , Grado de Desobstrucción Vascular
19.
Vasc Endovascular Surg ; 40(5): 362-6, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-17038569

RESUMEN

The combination of critical limb ischemia and end-stage renal failure (ESRF, ie, dialysis- dependent) represents severe systemic atherosclerosis and is associated with a very poor medium-term survival. Many nephrologists and surgeons advocate primary amputation. We examined the recent experience in this unit to determine whether infrainguinal bypass in these patients can be justified. Retrospective study of all patients with critical limb ischemia and ESRF undergoing surgery in a regional vascular and renal unit between January 1996 and May 2003. Forty-two patients with ESRF (median age 65 years) were referred with critical limb ischemia. Seventeen patients underwent 24 (7 bilateral) infrainguinal bypasses (17 autologous vein, 7 polytetrafluoroethylene [PTFE] conduit; tissue loss in 21/24, 88%), and 25 patients had primary major amputations of 32 limbs. Early occlusion occurred in 5 grafts (21%, all 5/5 PTFE). In-hospital mortality was 13% in the bypass group, 24% in the amputation group. Median in-hospital stay was 59 days in the bypass group, 46 days in the amputation group. Thirty-day, 1- and 2-year survival was 88%, 50%, and 33% in the bypass group; 83%, 39%, and 35% in the amputation group. The limb salvage rate was 66% at 1 year. Seventy-five percent (18/24) of operated on limbs (15/17 of vein grafts) avoided major amputation at follow-up (median 18 months) or death. The combination of critical limb ischemia and end- stage renal failure carries a poor medium-term survival independent of primary amputation or surgical revascularization. Infrainguinal bypass in selected cases with vein conduit can, however, allow the majority of these patients to avoid major limb amputation.


Asunto(s)
Implantación de Prótesis Vascular , Isquemia/cirugía , Recuperación del Miembro , Extremidad Inferior/irrigación sanguínea , Diálisis Renal , Venas/trasplante , Adulto , Anciano , Amputación Quirúrgica , Femenino , Oclusión de Injerto Vascular , Humanos , Isquemia/complicaciones , Isquemia/mortalidad , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/mortalidad , Fallo Renal Crónico/terapia , Masculino , Persona de Mediana Edad , Politetrafluoroetileno , Pronóstico , Estudios Retrospectivos , Análisis de Supervivencia , Factores de Tiempo , Resultado del Tratamiento
20.
Br J Hosp Med (Lond) ; 67(6): 305-8, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16821733

RESUMEN

Venous ulceration is a common clinical problem with high recurrence rates. The role of operative treatment to correct superficial reflux in venous ulceration remains unclear. This review reports current evidence for superficial surgical procedures in the treatment of venous ulceration.


Asunto(s)
Úlcera Varicosa/cirugía , Vendajes , Femenino , Humanos , Masculino , Prevención Secundaria , Resultado del Tratamiento , Procedimientos Quirúrgicos Vasculares/métodos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA