Exploring Research on the Construction and Application of Knowledge Graphs for Aircraft Fault Diagnosis.

Fault diagnosis is crucial for repairing aircraft and ensuring their proper functioning. However, with the higher complexity of aircraft, some traditional diagnosis methods that rely on experience are becoming less effective. Therefore, this paper explores the construction and application of an aircraft fault knowledge graph to improve the efficiency of fault diagnosis for maintenance engineers. Firstly, this paper analyzes the knowledge elements required for aircraft fault diagnosis, and defines a schema layer of a fault knowledge graph. Secondly, with deep learning as the main method and heuristic rules as the auxiliary method, fault knowledge is extracted from structured and unstructured fault data, and a fault knowledge graph for a certain type of craft is constructed. Finally, a fault question-answering system based on a fault knowledge graph was developed, which can accurately answer questions from maintenance engineers. The practical implementation of our proposed methodology highlights how knowledge graphs provide an effective means of managing aircraft fault knowledge, ultimately assisting engineers in identifying fault roots accurately and quickly.

The Urinary Metabolome of Healthy Newborns.

The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate's metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB.

Upregulation of acetylcholinesterase caused by downregulation of microRNA-132 is responsible for the development of dementia after ischemic stroke.

MicroRNA-132 (miR-132) has been shown to participate in many diseases. This study aimed to understand the correlation between the level of miR-132 and the severity of dementia post-ischemic stroke. An online tool (www.mirdb.org) was used to find the miR-132 binding site in acetylcholinesterase (ACHE) 3'-untranslated region (UTR), followed by a luciferase reporter assay to validate ACHE as a miR-132 target. A similar relationship between miR-132 and ACHE was also established in cerebrospinal fluid samples collected from human subjects. A negative correlation was established between ACHE and miR-132 by measuring the relative luciferase activity. Meanwhile, Western blot analysis and real-time polymerase chain reaction were also conducted to compare the levels of ACHE messenger RNA and protein between two groups (dementia positive, n = 26 and dementia negative, n = 26) or among cells treated with miR-132 mimics, ACHE small interfering RNA, and miR-132 inhibitors. As shown in the results, miR-132 can reduce the expression of ACHE. Further experiments were also carried out to study the effect of miR-132 and ACHE on cell viability and apoptosis, and the results demonstrated that miR-132 enhanced cell viability while suppressing apoptosis. In addition, ACHE reduced cell viability while promoting apoptosis. miR-132 targeted ACHE and suppressed its expression. Additionally, miR-132 and ACHE have been shown to affect the cell viability and apoptosis in the central nervous system.

Retracted: Long noncoding RNA MEG3 inhibits proliferation and migration but induces autophagy by regulation of Sirt7 and PI3K/AKT/mTOR pathway in glioma cells.

Glioma is a common primary brain tumor with high mortality rate and poor prognosis. Long noncoding RNA maternally expressed gene 3 (MEG3) is a tumor suppressor in diverse cancer types. However, the role of MEG3 in glioma remains unclear. We aimed to explore the effects of MEG3 on U251 cells as well as the underlying mechanisms. U251 cells were stably transfected with different recombined plasmids to overexpress or silence MEG3. Effects of aberrantly expressed MEG3 on cell viability, migration, apoptosis, expressions of apoptosis-associated and autophagy-associated proteins, and phosphorylated levels of key kinases in the PI3K/AKT/mTOR pathway were all evaluated. Then, messenger RNA (mRNA) and protein expression of Sirt7 in cells abnormally expressing MEG3 were estimated. In addition, effects of abnormally expressed MEG3 and Sirt7 on U251 cells were determined to reveal the underlying mechanism of MEG3-associated modulation. Cell viability and migration were significantly reduced by MEG3 overexpression whereas cell apoptosis as well as Bax and cleaved caspase-3/-9 proteins were obviously induced. Beclin-1 and LC3-II/LC3-I were upregulated and p62 was downregulated in MEG3 overexpressed cells. In addition, the autophagy pharmacological inhibitor (3-methyladenine, 3-MA) affected the effect of MEG3 overexpression on cell proliferation. Furthermore, the phosphorylated levels of key kinases in the PI3K/AKT/mTOR pathway were all reduced by MEG3 overexpression. Sirt7 was positively regulated by MEG3 expression, and effects of MEG3 overexpression on U251 cells were ameliorated by Sirt7 silence. MEG3 suppressed cell proliferation and migration but promoted autophagy in U251 cells through positively regulating Sirt7, involving in the inhibition of the PI3K/AKT/mTOR pathway.

Surgical and micro-invasive treatment of pancreatic duct stones: an analysis of 42 patients / 中华肝胆外科杂志

Pancreatic duct stone is a sequel of chronic pancreatitis and may be found in the main ducts,side branches or parenchyma.These stones obstruct the pancreatic ducts and produce ductal hypertension,which leads to pain,the cardinal feature of CP.Surgical operation has been the preferred treatment of pancreatic duct stones in many domestic and external pancreatic medical centers.Lithotomy by longitudinal pancreatic duct incision and Roux-en-Y anastomosis of pancreatic duct to jejunum is the main and effective surgical procedure,while micro-surgery was also rational for the treatment of pancreatic duct stones.However,further studies with a larger sample size and longer follow-up duration are needed to improve the surgical technique and verify our initial results.

Development and application of quality control system of ECG monitor / 医疗卫生装备

To develop intelligent informatized system for the quality control of ECG monitor. Based on the platform of PowerBuilder and SQL Server and using scientific management process as the standard, the informa-tized system was developed to cover all aspects of ECG monitor quality control. This informatized system, which closely accorded with related laws and regulations, had graded authority, clear responsibilities, multi functions and easy operation. Computer information technology plays an important role in scientific management system of ECG monitor quality control.

Research on intelligent quality control platform of ECG monitor / 医疗卫生装备

Objective To design a set of quality control management platform of ECG monitor in order to evaluate the quality of ECG monitor quickly and objectively and monitor and record the whole course of quality control.Methods The quality control platform was designed with the existing ECG monitor quality control methods, the existing detection devices, database technique and digital recognition technique based on neural network.Results The platform could be used for the intelligent data acquisition, data recognition, data analysis and statistics of ECG monitor quality control.Conclusion The platform may enhance the quality control of ECG monitor greatly.

Explore the feasibility of preventive maintenance model of hemodialysis machine based on quality control detection / 中国医学装备

Objective:To investigate the feasibility of hemodialysis machine preventive maintenance model of based on quality control detection.Methods: Selected sample of 32 hemodialysis machines of two major imported brands, 16 of them using the traditional preventive maintenance mode for maintenance, and the other 16 sets of quality control detection based preventive maintenance hemodialysis machine maintenance mode. That: by use of HDM99XP detector instrument for testing the five hemodialysis machine main indicators, maintenance cycle is 16 weeks, and then the equipment failure rate indicators of two modes of preventive maintenance were compared.Results: The hemodialysis machine preventive maintenance model of based on quality control detection rise superior to the traditional maintenance mode in lower failure rate, quantitative, objective, and less affected by human factors.Conclusion: The hemodialysis machine preventive maintenance model of based on quality control detection was better than the traditional preventive maintenance mode,also a promising preventive maintenance mode.

Definition and function identification of nucleus export signal of BRD7 / 中南大学学报(医学版)

OBJECTIVE@#To localize and define the region of nucleus export signal (NES) on BRD7, and determine the role of this region in nucleus export of the external protein.@*METHODS@#Based on an in vitro expressed model of green fluorescence protein (GFP), we performed DNA walking analysis to set BRD7 into several sections according to the structural characteristics of BRD7, investigated the effect of different sections of BRD7 on nucleus export of GFP, defined the region of nucleus export signal sequence of BRD7, and further ascertained the content of amino acids in BRD7 and potential localization of BRD7 NES by bioinformatics.@*RESULTS@#B7C1 fragments ranged from aa219 to aa450 in BRD7 were found to target the external protein GFP into the cytoplasm detected by GFP direct fluorescence, which could be inhibited by NES inhibitor Leptomycin B (LMB). This region was rich in hydrophobic amino acid residues but no typical NES with characteristics of leucine-rich sequence by bioinformatics.@*CONCLUSION@#The region from aa219 to aa450 is primarily defined as an atypical NES in BRD7.

[Stream ecosystem health assessment based on the measurement of leaf litter breakdown: a case study in Hengshishui River of Guangdong Province].

Based on the Gessner' s model of leaf litter breakdown, the functional integrity and ecosystem health of Hengshishui River in Guangdong Province were assessed, and the breakdown rates of Castanopsis fissa and Schima superba leaf litters at the sites unpolluted and polluted by acid mine drainage were compared. The leaf litters of the two tree species had a significantly lower breakdown rate at polluted than at unpolluted sites (P < 0.05). According the Gessner's model, all polluted sites had an ecosystem health score 0, while all unpolluted sites had a score 2, indicating that the health status of polluted river reaches were severely damaged. The biological assessment of stream ecosystem health was consistent with the results of water quality analysis, indicating that the leaf litter breakdown model was a suitable index of stream status.

Formaldehyde degradation by UV/TiO2/O3 process using continuous flow mode.

The degradation of formaldehyde gas was studied using UV/TiO2/O3 process under the condition of continuous flow mode. The effects of humidity, initial formaldehyde concentration, residence time and ozone adding amount on degradation of formaldehyde gas were investigated. The experimental results indicated that the combination of ozonation with photocatalytic oxidation on the degradation of formaldehyde showed a synergetic action, e.g., it could considerably increase decomposing of formaldehyde. The degradation efficiency of formaldehyde was between 73.6% and 79.4% while the initial concentration in the range of 1.84-24 mg/m3 by O3/TiO2/UV process. The optimal humidity was about 50% in UV/TiO2/O3 processs and degradation of formaldehyde increases from 39.0% to 94.1% when the ozone content increased from 0 to 141 mg/m3. Furthermore, the kinetics of formaldehyde degradation reaction could be described by Langmuir-Hinshelwood model. The rate constant k of 46.72 mg/(m3 x min) and Langmuir adsorption coefficient K of 0.0268 m3/mg were obtained.

[Roles of infochemicals in host-selection process of Anastatus japonicus].

By using a Y-tube olfactometer, this paper studied the selection behavior's responses of Anastatus japonicus to the volatiles and their individual components emitted from isolated leaves and live plants of different litchi varieties, and to Tessaratoma papillosa. The results showed that among the test litchi varieties, Sanyuehong and Huaizhi had more significant attracting effects to A. japonicus than Nuomici, Guiwei, Feizixiao and Heiye. The two main components of the volatiles from litchi leaves, alpha-humulene and beta-caryophyllene, had no distinct attraction to A. japonicus, but displayed synergistic effect on the host-searching process of natural enemy. When the two components were mixed in equal concentration of 0.3 microl x microl(-1), the attracting effect was most remarkable. In a dual-choice experiment, the selectivity of A. japonicus to T. papillosa eggs was not significant, but very remarkable to T. papillosa female adults and to the water extracts from adult abdomen-tip. In a vessel experiment, the numbers of A. japonicus which made selection to T. papillosa eggs and the settling frequency of A. japonicus on the place of T. papillosa eggs were more than those of other treatments. (E)-2-hexenal, one of the most important components of the volatiles of T. papillosa adult, didn't have evident attracting effect on the adults of A. japonicus.

A non-natural dinucleotide containing an isomeric L-related deoxynucleoside: dinucleotide inhibitors of anti-HIV integrase activity.

The first X-ray crystal structure of a non-natural dinucleotide, 5'-O-phosphoryl-1'-deoxy-2'-isoadenylyl-(3' --> 5')-cytidine 6.5-hydrate (pIsodApC), C19H26N8O13P2 x 6.5H2O, belonging to a family of dinucleotides that contain an isomeric nucleoside component, is described. A complex system of hydrogen bonds between water molecules and various sites on the dinucleotide was found. All H atoms were located from electron-density difference maps, which allowed identification of protonation sites. Compounds of this family have been found to bind at the active site of HIV integrase and to be inhibitors of this key viral enzyme. These dinucleotides are completely resistant to cleavage by exonucleases; an abnormal dihedral angle twist in an internucleotide phosphate bond revealed in the X-ray crystal structure may be contributing to this unusual stability towards nucleases.

Experience on Management of Medical Equipment in Hospital / 医疗卫生装备

Management on medical equipment is discussed and the utility and benefits are analyzed.Several aspects of management of medical equipment in our hospital are mainly introduced such as purchase,check & acceptance,use,maintenance,metrology and scrapping.

Consideration on Establishment of Third Class Medical Station in Army Hospital / 医疗卫生装备

Present situations of the third class medical station in army hospital are discussed in 3 aspects including the recognition of leaders,actualities of metrology work and situation of metrology personnel.Suggestions on the third class medical station are given as follows: cultivation of personnel to promote the construction of medical metrology station;information sharing to enhance metrology level;broad propaganda on metrology regulations to strengthen supervision;continuous subject construction of medical metrology.

Opinions concerning work of third class medical metrology stations in military hospital / 医疗卫生装备

This paper puts forward existing problems and conflicts in the work of third class medical metrology stations in army,raises suggestions from 5 aspects including enhancing metrology awareness,fulfilling rules,setting strict standards,etc.

Current Status and Development of Electric Operating Table / 医疗卫生装备

This article describes the functions and technical information based on the introduction of classification and theory of the operating table.Considering about the situation of manufacturers and applications,it also analyzes the current application status.According to the experience,it provides a means of maintenance and management.Finally,it introduces some kinds of multi-functions and professional electric operating table,and also figures out the developing trend of the separated electric operating system.

Quality Control During Medical Equipment Management / 医疗卫生装备

Objective To establish quality control system for medical equipment to ensure its application safety and quality. Methods All aspects of medical equipment management were analyzed. Results All aspects of medical equipment management had to be paid attention to. Conclusion Keeping Improved quality of medical equipment contributes to the decrease of the doctor-patient dispute.

Status, Causes and Countermeasures of Medical Equipment Quality Control in Military Hospitals / 医疗卫生装备

Quality control of medical equipment is very important to the diagnostic accuracy and the cure effect. The work of the quality control is the main technical basis of the hospital construction in promoting medical development, and it's also an important content of the modem medical management. The status, causes and countermeasures of medical equipment quality control in military hospital at the present time are analyzed and discussed.

Development of the professional person troops in Medical Engineering in military hospital / 医疗卫生装备

The function of Medical Engineering profession in military hospitals becomes more and more important,so does the development of the professional person troops.There is an urgent need of a professional person troop with high-tech professional knowledge,rigorous science style and good managerial ability.Therefore,it is necessary to develop the professional person troops in Medical Engineering in military hospital.