The COVID-19 vaccine did not affect the basal immune response and menstruation in female athletes.

The COVID-19 pandemic restricted the regular training and competition program of athletes. Vaccines against COVID-19 are known to be beneficial for the disease; however, the unknown side effects of vaccines and postvaccination reactions have made some athletes hesitant to get vaccinated. We investigated the changes in inflammatory responses and menstrual cycles of female athletes before and after vaccination. Twenty female athletes were enrolled in this study. Blood was collected from each subject before the first COVID-19 vaccination and after the first and second vaccinations. Laboratory data, including white blood cell, neutrophil, lymphocyte, and platelet counts, and inflammatory markers, including NLR (neutrophil-to-lymphocyte ratio), PLR (platelet lymphocyte ratio), RPR (red cell distribution width to platelet ratio), SII (systemic immune-inflammation index), and NeuPla (neutrophil-platelet ratio), were analyzed statistically. The menstrual changes before and after vaccination and the side effects were collected by questionnaires. No significant changes in the laboratory data were found after the first and second shots when compared to those at prevaccination: white blood cell, neutrophil, lymphocyte, platelet, NLR, PLR, SII, RPR, and NeuPla (p > 0.05). In addition, there were no significant changes in the menstruation cycle or days of the menstrual period (p > 0.05). All side effects after vaccination were mild and subsided in 2 days. The blood cell counts, inflammatory markers, and menstruation of female athletes were not affected by COVID-19 vaccines.

Structure and Magnetic Properties of Co40Fe40V20 Thin Films.

This study investigated the structure and magnetic properties of Co40Fe40V20 thin films with a thicknesses (tf) of 10 nm to 100 nm on a glass substrate. The X-ray diffraction (XRD) patterns of the CoFeV films demonstrated a significant crystalline body-centered cubic (BCC) CoFe (110) structure when the thickness was between 60 and 100 nm, and an amorphous status were shown when the thickness was from 10 to 50 nm. The strongest crystalline XRD peak was at 60 nm because it had a continuous mode of film growth and induced a large grain distribution. The low-frequency alternating current magnetic susceptibility (Ï°ac) property decreased when the frequency increased. The lowest Ï°ac value was detected at 60 nm owing to the large grain distribution inducing high coercivity (Hc) and then enhancing the spin coupling strength. The external field (Hext) was difficult to rotate spin state, then deduces the spin sensitivity and Ï°ac value is decreased. The highest Ï°ac meant the spin sensitivity was maximized at the optimal resonance frequency. The 50-mm thickness had the highest Ï°ac 0.045 value at an fres of 100 Hz. The fres value was less than 1000 Hz at all CoFeV thicknesses, suggesting that CoFeV films would be suitable for low-frequency magnetic component applications. Moreover, the saturation magnetization (Ms) revealed a thickness effect when the thicknesses had a larger Ms. The Hc values were between 3 Oe and 10 Oe at all CoFeV films, except for 60 nm. The Hc of the 60 nm film was about 80 Oe due to the larger grain distribution, and it induced strong remanent magnetization (Mr) and a larger squareness ratio (Mr/Ms) of 92%. The results of the magnetic measurement showed that the 60 nm Co40Fe40V20 film had greater Hc and a good squareness ratio.

Correlations between Histological and Array Comparative Genomic Hybridization Characterizations of Wilms Tumor.

Wilms tumor, or nephroblastoma, is the most common pediatric renal malignancy. Its diagnosis is principally based on histology. Several genetic loci have been shown to be associated with Wilms tumor formation, including WT1, WT2, FWT1, FWT2, CTNNB1, WTX, and TP53. Other loci, such as 1p, 2q, 7p, 9q, 12q, 14q, 16q, 17p, and 22, have also been implicated in the etiology of Wilms tumor. The aim of this study is to elucidate the molecular pathogenesis of this tumor. In the present study, we analyzed the histological appearance and copy number aberrations using array comparative genomic hybridization of six Wilms tumors without somatic mutation in the WT1 gene. Many chromosomal aberrations on array comparative genomic hybridization analysis revealed that the genetics of Wilms tumors are extremely complex. Amplifications and deletions of large DNA fragments were observed in some samples. Amplifications of NDUFV1, ZIC2, SIX1, NR2F2, MIR1469, SOX9, JAG1, MIR6870, and GNAS were found in all six Wilms tumors. Moreover, amplifications of five genes were identified in the Wilms tumors of stromal type and amplifications of at least 10 genes were identified in the Wilms tumors of epithelial type. Our results indicated that amplifications of nine genes are the essential events in the tumorigenesis of Wilms tumor, which may inform its clinical and therapeutic management. In addition, mixed type Wilms tumor may be the heterogeneous group able to be classified using genetic results of epithelial and stromal components based on immunohistochemistry.

Association of primary immune thrombocytopenia and common allergic diseases among children.

BACKGROUND: Growing evidence has revealed a link between autoimmune and allergic diseases. However, few studies have assessed the relationship between allergic diseases and primary immune thrombocytopenia (ITP), an autoimmune disease frequently occurring in children. This population-based case-control study investigated the association between common allergic diseases and the subsequent risk of developing ITP during childhood. METHODS: This study investigated 1,203 children younger than 18 y of age who were diagnosed with ITP between 1998 and 2008, as well as 4,812 frequency-matched controls. The odds ratios of the association between ITP and preexisting allergic diseases were calculated. RESULTS: Children with every type of allergic disease examined in this study (except asthma) exhibited an increased risk of developing ITP; the lowest adjusted odds ratio (aOR) was 1.39 for allergic conjunctivitis (95% confidence interval (CI) = 1.09-1.79), whereas the greatest aOR was 1.84 for allergic rhinitis (95% CI = 1.49-2.27). The aORs increased with the number of concurrent allergic diseases to 2.89 (95% CI = 1.98-4.22) for children with at least three allergic diseases. CONCLUSION: Children with atopic diathesis have a greater risk of subsequently developing ITP. The fundamental determinants of this relationship warrant further study.