Asunto(s)
Enfermedades del Colon/diagnóstico por imagen , Hernia Abdominal/diagnóstico por imagen , Obstrucción Intestinal/etiología , Sulfato de Bario , Enfermedades del Colon/complicaciones , Enfermedades del Colon/cirugía , Femenino , Estudios de Seguimiento , Hernia Abdominal/complicaciones , Hernia Abdominal/cirugía , Humanos , Obstrucción Intestinal/diagnóstico por imagen , Obstrucción Intestinal/cirugía , Laparotomía/métodos , Región Lumbosacra , Persona de Mediana Edad , Enfermedades Raras , Medición de Riesgo , Tomografía Computarizada por Rayos X , Resultado del TratamientoRESUMEN
The significance and effectiveness of adjuvant intraoperative chemotherapy using subserosal or submucosal administration of Neocarzinostatin (NCS) and CH 40 for gastric cancer and colorectal cancer were studied. Tissue NCS concentration of proximal lymph nodes were higher than for distant lymph nodes, while the immunocompetency of distant lymph nodes (lower NCS concentration) showed slightly higher activity than that of proximal lymph nodes. From these results, it is suggested that loco-regional administration of NCS might be effective for chemical lymph node cleaning of the cancer.
Asunto(s)
Neoplasias del Colon/tratamiento farmacológico , Neoplasias del Recto/tratamiento farmacológico , Neoplasias Gástricas/tratamiento farmacológico , Cinostatina/administración & dosificación , Carbono , Quimioterapia Adyuvante , Neoplasias del Colon/metabolismo , Mucosa Gástrica , Humanos , Inyecciones Intralesiones , Ganglios Linfáticos/metabolismo , Activación de Linfocitos , Neoplasias del Recto/metabolismo , Neoplasias Gástricas/metabolismo , Cinostatina/farmacocinéticaAsunto(s)
Neoplasias Gástricas/tratamiento farmacológico , Cinostatina/administración & dosificación , Humanos , Inyecciones/métodos , Ganglios Linfáticos/metabolismo , Ganglios Linfáticos/patología , Metástasis Linfática , Membrana Serosa , Estómago , Neoplasias Gástricas/metabolismo , Neoplasias Gástricas/patología , Distribución Tisular , Cinostatina/farmacocinéticaRESUMEN
Out of 127 gastric cancer cases with a synchronous liver metastases, the relationship between the prognosis and the nuclear DNA contents in the primary and liver metastatic foci has been investigated in 10 relatively noncurative patients who had received a combined gastrectomy and hepatectomy. In 3 out of 5 long-term survival cases, low ploidy patterns were seen in both foci, whereas in 1 out of 5 short-term survival cases, a multiplicity was observed, i.e., a low ploidy in the primary focus and a high ploidy in the liver. In the other 4 short-term survival cases, high ploidy patterns were noted in both foci.
Asunto(s)
ADN de Neoplasias/análisis , Gastrectomía , Hepatectomía , Neoplasias Hepáticas/química , Neoplasias Gástricas/química , Anciano , Núcleo Celular/química , Femenino , Gastrectomía/mortalidad , Hepatectomía/mortalidad , Humanos , Neoplasias Hepáticas/secundario , Neoplasias Hepáticas/cirugía , Masculino , Persona de Mediana Edad , Ploidias , Pronóstico , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugía , Tasa de SupervivenciaRESUMEN
A microspectrophotometric analysis of the DNA content has been performed on 9 advanced recurrent gastric cancer patients with measurable lesions, who has either been treated by CDDP alone or with other chemotherapeutics during a three-year period since, 1984. Histograms of the DNA content were classified into four ploidy patterns. All of the 4 responder cases (CR, PR, MR) showed type, IV, although only one of 5 non-responder cases revealed the same typing. In one of the two CR cases the DNA ploidy pattern, which was examined before and after the therapy, changed from type IV to type II. Thus it appears that an analysis of the DNA content may be useful in evaluating the effectiveness of different chemotherapies.