Asunto(s)
Hipopigmentación , Enfermedades del Iris , Degeneración Macular , Enfermedades de la Retina , Humanos , Enfermedades del Iris/diagnóstico , Enfermedades del Iris/etiología , Hipopigmentación/diagnóstico , Hipopigmentación/etiología , Enfermedades de la Retina/diagnóstico , Enfermedades de la Retina/etiología , Iris/cirugía , Rayos LáserRESUMEN
AIM: To compare the efficacy, tolerability and safety of bromfenac 0.09%, nepafenac 0.1% or diclofenac 0.1% for the prophylaxis of the cystoid macular edema (CME) after phacoemulsification. METHODS: Group sequential observational comparative study. After phacoemulsification, patients received two months for topical treatment of either diclofenac sodium, bromfenac or nepafenac. All patients received concomitant topical tobramycin 0.3% and topical prednisolone 1%. We measured CME using optical coherence tomography (OCT) central foveal thickness, macular thickness and total macular volume. RESULTS: We enrolled 243 patients from January to June 2015, and 35% received diclofenac, 32.9% bromfenac and 32.1% nepafenac. When we compared pre-operative to three weeks to two months, bromfenac was more effective in reducing foveal volume (21.3 and 35.4 mm3, respectively), compared with the diclofenac (1.3 and 11.5 mm3, respectively), and the nepafenac group, became more edematous 6.4 and 5.3, respectively. Totally 133 patients completed the post-surgical satisfaction questionnaire. Patients complained of eye stickiness in 13.8% whom we gave nepafenac, versus 10.3% whom we gave diclofenac sodium, and in 0 whom we gave bromfenac. CONCLUSION: Bromfenac is the best tolerated and is more effective than diclofenac and nepafenac in reducing CME after phacoemulsification.
Asunto(s)
Anticuerpos Monoclonales Humanizados/uso terapéutico , Coroiditis/tratamiento farmacológico , Adalimumab , Adulto , Antiinflamatorios/uso terapéutico , Coroiditis/diagnóstico , Angiografía con Fluoresceína , Fondo de Ojo , Humanos , Masculino , Coroiditis Multifocal , Tomografía de Coherencia Óptica , Factor de Necrosis Tumoral alfa/antagonistas & inhibidoresRESUMEN
Vitreous amyloidosis is characterized by progressive loss of vision from amyloid accumulation of deposits on the retina and in the vitreous. Time domain optical coherence tomography (TD-OCT) was used in a case of familial transthyretin vitreous amyloidosis Met30 mutation to image the anterior vitreous deposits, which showed high reflectivity of very different from vitreous found in unaffected individuals. TD-OCT may be a useful adjunctive test to diagnose vitreous amyloidosis when masquerade syndromes are suspected. There may be more easeful imaging in TD-OCT of vitreous abnormalities than with spectral domain OCT (SD-OCT). Further study should be performed comparing TD versus SD-OCT in families with vitreous amyloidosis and TD vitreous amyloidosis versus TD in other intermediate uveitis.