Is repeat wide excision plus radiotherapy of localized rectal melanoma another choice before abdominoperineal resection? A case report.

BACKGROUND: Rectal melanoma is an uncommon neoplasm that accounts for approximately 1 percent of rectal cancer cases. Abdominoperineal resection was regarded as the radical procedure for disease control. Nevertheless, it led to more postoperative complications than sphincter-sparing wide local excision (WLE) and reduced the patient's quality of life (QOL) owing to creation of colostomy. Therefore, in this study, WLE, radiotherapy (RT), and a second WLE were conducted on a patient who had been diagnosed with localized rectal melanoma. CASE SUMMARY: The patient was a 79-year-old woman who had been experiencing anal pain and bloody stool for 1 mo. Colonoscopy, magnetic resonance imaging, positron emission tomography-computed tomography, and histological analysis of tissue biopsy using the histological markers Melan-A (+), S-100 (+), and Ki-67 (+, 50%) lead to the diagnosis of localized rectal melanoma. The patient had initially undergone WLE to resolve problem of anal bleeding, followed by RT to treat the residual lesion with partial response. Subsequently, the residual lesion was removed with margin-free resection by the second WLE. The patient's postoperative course was smooth and uneventful. During the 2-year follow-up, no local recurrence was observed. Additionally, a good functional outcome and improved QOL were reported. CONCLUSION: Combining WLE, RT, and repeat WLE is proposed as a viable alternative for treating rectal melanoma accompanied by bleeding symptoms that cannot be completely resected at the beginning.

Combined Ileoileal and Ileocolic Intussusception Secondary to Inflammatory Fibroid Polyp in an Adult: A Case Report.

Intestinal intussusception is relatively rare in adults and accounts for approximately 5% of intestinal obstruction. Intussusception is classified into subtypes according to the location, including ileoileal, ileocolic, ileo-ileocolic, colo-colic, jejuno-ileal, or jejuno-jejunal; the ileocolic type being the most common. However, intussusception of a combination of different subtypes has rarely been reported in the available literature. Abdominal computed tomography (CT) is the most accurate tool to evaluate intestinal intussusception. The pathological lead point in the intestine typically results in adult intussusception. Surgical intervention is usually adopted in cases of adult intussusception due to a high incidence of underlying bowel malignancy. An inflammatory fibroid polyp (IFP) is one of the uncommon benign neoplasms of the gastrointestinal (GI) system, which can result in intestinal intussusception. Herein, we present a case of a 50-year-old female with combined ileoileal and ileocolic intussusception, which was initially diagnosed by abdominal CT. Therefore, laparoscopic right hemicolectomy surgery was performed, confirming the final diagnosis as ileoileal and ileocolic intussusception secondary to IFP.

Duodenal Ulcer with Massive Gastrointestinal Hemorrhage as an Initial Manifestation in Multiple Myeloma with Extramedullary Disease: A Case Report.

Plasma cell neoplasms are characterized by dysregulated proliferation of mature B cells, which can present with either single (solitary plasmacytoma) or systemic (multiple myeloma (MM)) involvement. MM with extramedullary plasmacytoma (EMP) is a rare disease that accounts for approximately 3-5% of all plasmacytomas. EMP with gastrointestinal (GI) system involvement is an even rarer entity, accounting for <1% of MM cases. We present a case of aggressive MM with EMP invading the duodenum, initially presented with massive upper GI hemorrhage and small bowel obstruction. A 67-year-old woman was admitted to our hospital owing to a lack of either gas or feces passage for 3 days. Abdominal distention and vomit with a high coffee ground content were observed for 24 h. The patient's condition was initially diagnosed as small bowel obstruction, upper gastrointestinal bleeding, severe anemia, acute renal failure, and hypercalcemia. Furthermore, an analysis of immunoelectrophoresis in the blood, bone marrow aspiration, and tissue biopsy supported the diagnosis of MM and EMP invading the duodenum, upper GI hemorrhage, and small bowel obstruction. Our study provided the possible involvement of MM and EMP in the differential diagnosis of patients with unexplained GI hemorrhage and small bowel obstruction. A thorough review of the literature regarding the association between MM, GI hemorrhage, and small bowel obstruction is presented in this study.

Comparing Single- and Dual-Antiplatelet Therapies After Transcatheter Aortic Valve Implantation.

BACKGROUND: Transcatheter aortic valve implantation has been an established treatment in patients with symptomatic severe aortic stenosis. However, the postoperative antiplatelet regimen after transcatheter aortic valve implantation has not been established with certainty. This meta-analysis compared the safety and efficacy of single- antiplatelet therapies (SAPTs) and dual-antiplatelet therapies (DAPT) in patients undergoing transcatheter aortic valve implantation. METHODS: Eligible randomized controlled trials and cohort studies published before February 2021 were retrieved from PubMed, Embase, and the Cochrane Library. We calculated odds ratios (ORs) with 95% CIs. RESULTS: Nine articles, involving 19 277 patients, met the selection criteria. In the short-term outcome, compared with SAPT, DAPT was associated with a significantly higher rate of bleeding (OR, 3.00; 95% CI, 1.67-5.38) and showed no significant differences in thrombotic events (OR, 1.25; 95% CI, 0.74-2.11) and all-cause mortality (OR, 0.84; 95% CI, 0.42-1.69). In the long-term outcome, DAPT was associated with a significantly higher bleeding rate (OR, 1.85; 95% CI, 1.24-.78) and showed no differences in thrombotic events (OR, 1.13; 95% CI, 0.86-1.48) and all-cause mortality (OR, 1.12; 95% CI, 0.95-1.32). Our trial sequential analysis confirmed DAPT did not confer any benefit for reducing all-cause mortality and thrombotic events and carried a higher risk of bleeding than SAPT. CONCLUSIONS: SAPT should be a sufficient antiplatelet strategy in patients after transcatheter aortic valve implantation who do not have indications for oral anticoagulation medication, especially in the long-term follow-up period.

Average urinary flow rate and its association with handgrip strength.

BACKGROUND: Voiding dysfunction became a difficult problem for the elderly because of the underactive bladder (UAB). It was considered that the degeneration of detrusor muscle was the main etiology. In recent years, more articles focus on relationship between UAB and decreased muscle strength. Besides, handgrip strength (HGS) is an early indicator to detect frailty and muscle weakness in systemic reviews. METHOD: Our study involved 2258 males from NHANES datasets (2011-2012, who were divided into quartiles by urine flow rate (UFR), which was measured by uroflowmetry. Multivariate regression models were performed to analyze the associations between UFR and HGS. RESULTS: The UFR had a positive correlation to the HGS by multivariate regression models in males (ß coefficient: 1.348, 95% confidence interval (CI): 0.530, 2.166, p = 0.001). The male participants with the highest quartile of UFR have a greater HGS than those with lowest quartile of UFR (ß coefficient: 4.546, 95% CI: 2.462, 6.630, p < 0.001). Higher UFR was associated with lower odds of low HGS (OR: 0.489, 95% CI: 0.350, 0.684, p < 0.001) in the fully-adjusted model. CONCLUSIONS: Our research highlighted that the UFR had a strong associated with the HGS in the healthy group.

Examining the association between grip strength and testosterone.

BACKGROUND: Skeletal muscle is an important site for storing proteins and providing general physical function. Recent research has shown that muscle strength decreases earlier than muscle mass decreases, as shown during the aging process. Our article aimed to compare the association between testosterone levels and grip strength to provide an earlier biomarker to detect muscle weakness. METHOD: We adopted quartile-based analysis by dividing handgrip power into quartiles, with all participants in the lowest quartile serving as the reference group. Linear regression analysis was conducted between handgrip power and testosterone. Logistic regression models were used to analyze the longitudinal correlation between testosterone levels and the presence of low muscle strength. RESULTS: Serum testosterone levels had a significant correlation with grip strength in all models (p < .001). In addition, high testosterone levels were negatively associated with low muscle strength in all groups (p < .001). A stronger relationship was observed between testosterone levels and grip strength among non-obese participants than among obese participants. CONCLUSIONS: In conclusion, our study highlighted that testosterone levels are related to greater grip strength.