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1.
Biomed Res Int ; 2014: 635923, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24795890

RESUMEN

Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and prevention of PD. The present study demonstrated that leukocyte apoptosis is significantly higher in PD patients and is associated with central dopamine neuron loss by using (99m)Tc-TRODAT-1 SPECT. The leukocyte apoptosis and striatal dopamine transporter uptake ratios were further associated with increased severity and longer duration of disease. The interaction between brain and systemic inflammation may be responsible for the neurodegenerative disease progression.


Asunto(s)
Apoptosis , Encéfalo/citología , Leucocitos/citología , Trastornos Parkinsonianos/patología , Trastornos Parkinsonianos/fisiopatología , Anciano , Encéfalo/patología , Estudios de Cohortes , Femenino , Humanos , Leucocitos/patología , Masculino , Persona de Mediana Edad , Neuroimagen , Trastornos Parkinsonianos/sangre , Trastornos Parkinsonianos/epidemiología , Tomografía Computarizada de Emisión de Fotón Único
2.
Biomed Res Int ; 2014: 340936, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24804213

RESUMEN

The oxidative stress is believed to be one of the mechanisms involved in the neuronal damage after acute traumatic brain injury (TBI). However, the disease severity correlation between oxidative stress biomarker level and deep brain microstructural changes in acute TBI remains unknown. In present study, twenty-four patients with acute TBI and 24 healthy volunteers underwent DTI. The peripheral blood oxidative biomarkers, like serum thiol and thiobarbituric acid-reactive substances (TBARS) concentrations, were also obtained. The DTI metrics of the deep brain regions, as well as the fractional anisotropy (FA) and apparent diffusion coefficient, were measured and correlated with disease severity, serum thiol, and TBARS levels. We found that patients with TBI displayed lower FAs in deep brain regions with abundant WMs and further correlated with increased serum TBARS level. Our study has shown a level of anatomic detail to the relationship between white matter (WM) damage and increased systemic oxidative stress in TBI which suggests common inflammatory processes that covary in both the peripheral and central reactions after TBI.


Asunto(s)
Hemorragia Encefálica Traumática/sangre , Cerebelo/metabolismo , Estrés Oxidativo , Enfermedad Aguda , Adolescente , Adulto , Biomarcadores/sangre , Hemorragia Encefálica Traumática/patología , Cerebelo/patología , Humanos , Persona de Mediana Edad , Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismo
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